A5054366581- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Cholinesterase and Neurodegenerative Diseases
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Skin Protection and Aging
- RNA regulation and disease
- Ethnobotanical and Medicinal Plants Studies
- Cholesterol and Lipid Metabolism
- Natural Antidiabetic Agents Studies
- Kruppel-like factors research
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Peroxisome Proliferator-Activated Receptors
- IL-33, ST2, and ILC Pathways
- GDF15 and Related Biomarkers
- Caveolin-1 and cellular processes
Harvard University
2022-2024
Brigham and Women's Hospital
2022-2024
New York University
2019-2023
Beth Israel Deaconess Medical Center
2022-2023
Cancer Research Institute
2023
Guru Nanak Dev University
2023
University of Otago
2013-2021
Universitas Garut
2015
Lovely Professional University
2012
Government Medical College, Amritsar
2009
Abstract Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a substantial protumorigenic immune component. Knowledge of the GBM microenvironment during tumor evolution and standard care treatments limited. Using single-cell transcriptomics flow cytometry, we unveiled large-scale comprehensive longitudinal changes in cell composition throughout progression epidermal growth factor receptor-driven genetic mouse model. We identified subsets proinflammatory...
Microangiopathy due to endothelial dysfunction is a major contributing factor the development of diabetes-induced cardiovascular disease (CVD). Dysregulation endothelial-specific microRNAs (miRs) correlated with impaired angiogenesis and cell survival. We investigated profile two angiomiRs, miR-126, miR-132, in plasma type 2 diabetic individuals without any known history CVD as well cardiac tissues collected from diabetics undergoing surgery.The presence diabetes alone significantly...
Aim: Myocardial fibrosis is a well-established cause of increased myocardial stiffness and subsequent diastolic dysfunction in the diabetic heart. The molecular regulators that drive process fibrotic events heart are still unknown. We determined role microRNA (miR)-15 family remodelling Methods results: Right atrial appendage (RAA) left ventricular (LV) biopsy tissues collected from non-diabetic (ND) patients undergoing coronary artery bypass graft surgery showed significant down-regulation...
The diabetic heart undergoes remodelling contributing to an increased incidence of failure in individuals with diabetes at a later stage. molecular regulators that drive this process the are still unknown. Real-time (RT) PCR analysis was performed determine expression cardiac specific microRNA-208a right atrial appendage (RAA) and left ventricular (LV) biopsy tissues collected from non-diabetic patients undergoing coronary artery bypass graft surgery. To time-dependent changes, tissue were...
The composition of the tumor immune microenvironment (TIME) is considered a key determinant patients' response to immunotherapy. mechanisms underlying TIME formation and development over time are poorly understood. Glioblastoma (GBM) lethal primary brain cancer for which there no curative treatments. GBMs immunologically heterogeneous impervious checkpoint blockade immunotherapies. Utilizing clinically relevant genetic mouse models GBM, we identified distinct landscapes associated with...
Abstract Background Acetylcholine (ACh) plays a crucial role in the function of heart. Recent evidence suggests that cardiomyocytes possess non-neuronal cholinergic system (NNCS) comprises choline acetyltransferase (ChAT), transporter 1 (CHT1), vesicular acetylcholine (VAChT), acetylcholinesterase (AChE) and type-2 muscarinic ACh receptors (M 2 AChR) to synthesize, release, degrade as well for transduce signal. NNCS is linked cardiac cell survival, angiogenesis glucose metabolism. Impairment...
Abstract Current therapeutic strategies for the treatment of critical limb ischemia (CLI) have only limited success. Recent in vitro evidence literature, using cell lines, proposes that peptide hormone ghrelin may angiogenic properties. In this study, we aim to investigate if could promote postischemic angiogenesis a mouse model CLI and, further, identify mechanistic pathway(s) underpin ghrelin's proangiogenic was induced male CD1 mice by femoral artery ligation. Animals were then randomized...
Abstract Aims Diabetes leads to dysregulated macrophage immunometabolism, contributing accelerated atherosclerosis progression. Identifying critical factors restore metabolic alterations and promote resolution of inflammation remains an unmet goal. MicroRNAs orchestrate multiple signalling events in macrophages, yet their therapeutic potential diabetes-associated unclear. Methods results miRNA profiling revealed significantly lower miR-369-3p expression aortic intimal lesions from Ldlr–/–...
Acyl-CoA synthetase 1 (ACSL1) is an enzyme that converts fatty acids to acyl-CoA-derivatives for lipid catabolism and synthesis in general can provide substrates the production of mediators inflammation monocytes macrophages. Acsl1 expression increased by hyperglycemia inflammatory stimuli macrophages, promotes pro-atherosclerotic effects diabetes mice. Yet, surprisingly little known about mechanisms underlying transcriptional regulation. Here we demonstrate glucose-sensing transcription...
<div>Abstract<p>The composition of the tumor immune microenvironment (TIME) is considered a key determinant patients’ response to immunotherapy. The mechanisms underlying TIME formation and development over time are poorly understood. Glioblastoma (GBM) lethal primary brain cancer for which there no curative treatments. GBMs immunologically heterogeneous impervious checkpoint blockade immunotherapies. Utilizing clinically relevant genetic mouse models GBM, we identified distinct...
The profound effects of hyperglycaemia on the vascular tree are major causes morbidity and mortality among patients suffering from diabetes. Diabetic Vascular Diseases (DVD) includes accelerated forms atherosclerosis due to endothelial dysfunction microangiopathy retinal vessels. A host several studies indicate that increased oxidative stress play a pivotal role in development progression diabetic diseases. metabolic abnormalities linked structural functional changes vasculature,...
Introduction: Hyperglycemia-induced immunometabolic alterations promote myelopoiesis, increase proinflammatory monocytes, and impair atherosclerosis regression. Identifying critical factors to restore metabolic resolution of inflammation remains an unmet medical need. MicroRNAs (miRs) orchestrate multiple signaling events in macrophages regulate inflammation. Using miR-seq, we identified miR-369-3p as a novel miR expressed higher regressing mouse plaques. Hypothesis: Therapeutic...
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