A5066789680- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Urinary and Genital Oncology Studies
- Organ Transplantation Techniques and Outcomes
- Cell Adhesion Molecules Research
- Uterine Myomas and Treatments
- Lymphoma Diagnosis and Treatment
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver physiology and pathology
- Viral Infections and Outbreaks Research
- Immune responses and vaccinations
- Pancreatic function and diabetes
- Viral-associated cancers and disorders
- Endometriosis Research and Treatment
- Peroxisome Proliferator-Activated Receptors
Beth Israel Deaconess Medical Center
2022-2024
Harvard University
2023-2024
Cancer Research Institute
2023
Hadassah Medical Center
2022
Hellenic Air Force
2022
University of Birmingham
2017-2021
Abstract The inhibitory receptor PD-1 suppresses T cell activation by recruiting the phosphatase SHP-2. However, mice with a T-cell-specific deletion of SHP-2 do not have improved antitumor immunity. Here we showed that conditional targeting in myeloid cells, but had diminished tumor growth. RNA sequencing (RNA-seq) followed gene set enrichment analysis indicated presence polymorphonuclear myeloid-derived suppressor cells and tumor-associated macrophages (TAMs) enriched expression profiles...
Objective Tissue-resident memory T cells (T RM ) are vital immune sentinels that provide protective immunity. While hepatic CD8 + have been well described, little is known about the location, phenotype and function of CD4 . Design We used multiparametric flow cytometry, histological assessment novel human tissue coculture systems to interrogate ex vivo phenotype, generation intrahepatic T-cell compartment. also leukocytes isolated from leukocyte antigen (HLA)-disparate liver allografts...
The composition of the tumor immune microenvironment (TIME) is considered a key determinant patients' response to immunotherapy. mechanisms underlying TIME formation and development over time are poorly understood. Glioblastoma (GBM) lethal primary brain cancer for which there no curative treatments. GBMs immunologically heterogeneous impervious checkpoint blockade immunotherapies. Utilizing clinically relevant genetic mouse models GBM, we identified distinct landscapes associated with...
<div>Abstract<p>The composition of the tumor immune microenvironment (TIME) is considered a key determinant patients’ response to immunotherapy. The mechanisms underlying TIME formation and development over time are poorly understood. Glioblastoma (GBM) lethal primary brain cancer for which there no curative treatments. GBMs immunologically heterogeneous impervious checkpoint blockade immunotherapies. Utilizing clinically relevant genetic mouse models GBM, we identified distinct...
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ABSTRACT Background & Aims Tissue-resident memory T cells (T RM ) are important immune sentinels that provide efficient in situ immunity. Liver-resident CD8 + have been previously described, and contribute to viral control persistent hepatotropic infections. However, little is known regarding liver CD4 cells. Here we profiled resident non-resident intrahepatic cell subsets, assessing their phenotype, function, differential generation requirements roles infection. Methods Liver tissue was...
<p>supplementary figures & legends</p>
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<p>Supplementary table 2</p>
<p>Supplementary Table 1</p>
<p>Supplementary Table 1</p>