A5070274657- Hormonal Regulation and Hypertension
- Heart Failure Treatment and Management
- Renin-Angiotensin System Studies
- Apelin-related biomedical research
- Cardiovascular Function and Risk Factors
- Pharmaceutical and Antibiotic Environmental Impacts
- Cardiovascular and exercise physiology
- Meat and Animal Product Quality
- Calpain Protease Function and Regulation
- Cardiac electrophysiology and arrhythmias
- Animal Nutrition and Physiology
- Blood Pressure and Hypertension Studies
- Genetics and Physical Performance
- Angiogenesis and VEGF in Cancer
- Chromium effects and bioremediation
- Obesity, Physical Activity, Diet
- Plant Pathogenic Bacteria Studies
- Muscle metabolism and nutrition
- Hair Growth and Disorders
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Plant-Microbe Interactions and Immunity
- Adipokines, Inflammation, and Metabolic Diseases
- Heavy metals in environment
- Sports Performance and Training
Massey University
2013-2025
University of Otago
2008-2024
University of Auckland
2010
Lincoln University
1996-2001
The University of Tokyo
2001
University of Canterbury
1993-1994
University of Massachusetts Chan Medical School
1991
Antimicrobial resistance (AMR) threatens human and ecological health worldwide. Unless major changes occur across the human, animal environmental sectors, problem will continue to expand. An important component of AMR that deserves greater attention is influence emerging organic contaminants (EOCs) – ubiquitous compounds found, amongst others, in pharmaceuticals, personal care products, food, industrial agricultural plastics building materials. EOCs are widely used can accumulate environment...
AimsPlasma aldosterone levels have been shown to be associated with adverse clinical outcomes after ST-elevation myocardial infarction (STEMI). We investigated whether in patients presenting STEMI or non-STEMI, are predictive of mortality during prolonged follow-up.
Agricultural soils accumulate inorganic contaminants from the application of phosphate fertilisers. An airstrip located at Belmont Regional Park (BRP), near Wellington, New Zealand, has been found to have a gradient cadmium contamination due spillage superphosphate fertiliser. Soil samples BRP with contamination, were used as novel source explore bacterial communities' resistance heavy metals (HMs) and any co-selected antibiotic (Ab) resistance. Differences between soil higher levels HMs...
Insulin-like growth factor 1 (IGF-1) has been identified as an important in many biological systems.[1] It shares considerable structural homology with insulin and exerts insulin-like effects on food intake glucose metabolism. Recently it suggested to play a role regulating cellular proliferation migration during the development of hair follicles. [2,3] To exert its effects, IGF-1 is required activate cells by binding specific cell-surface receptors. The type I IGF receptor (IGF-1R) only...
Background and Aims The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in mitochondrial tetrahydrofolate metabolism. Polymorphisms MTHFD1L, including rs6922269, have been implicated risk for coronary artery disease (CAD). We investigated the association between rs6922269 known metabolic factors survival two independent cohorts of heart patients. Methods Results DNA plasma from 1940 patients with acute syndromes were collected a median 32 days...
Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, left ventricular hypertrophy. In this study, heart failure patients (n=451) were genotyped for the angiotensinogen to investigate association survival (recorded over 4 years follow-up) prognostic hormone markers. Patients carrying 235TT genotype (n=86) 3 younger at admission (P=0.011), and, in those diagnosis was made approximately 10 earlier than...
Background— Chromosome 9p21.3 (chr9p21.3) recently was identified by several genome-wide association studies as the genomic region most strongly associated with risk of coronary artery disease. Within chr9p21.3 locus, single-nucleotide polymorphism rs1333049 has been demonstrated to be susceptibility developing However, effect on clinical outcomes in patients established disease yet determined. Methods and Results— Coronary Disease Cohort Study (CDCS) (n=1054) Post-Myocardial Infarction...
Accumulation of trace elements (including heavy metals) in soil from usage superphosphate fertilisers induces resistance bacteria to environmental concern (TEoEC) and may co-select for antibiotics (Ab). This study aimed investigate selection co-resistance Cd, Zn Hg, Ab soils with varied management histories. Genetic diversity these horizontal transfer Cd genes (cadA czcA) were also investigated. Soils either pastoral arable histories high levels Zn, or indigenous bush background TEoEC the...
Journal Article Rapid communication: PCR-RFLP for MspI and NcoI in the ovine calpastatin gene Get access B. R. Palmer, Palmer 2Molecular Biotechnology, Animal Veterinary Sciences, Lincoln University, Canterbury, New Zealand Search other works by this author on: Oxford Academic PubMed Google Scholar N. Roberts, Roberts J.G.H. Hickford, Hickford Bickerstaffe of Science, Volume 76, Issue 5, May 1998, Pages 1499–1500, https://doi.org/10.2527/1998.7651499x Published: 01 1998 history Received: 15...
Maintaining high levels of physical function is an important aspect successful ageing. While muscle mass and strength contribute to functional performance in older adults, little known about the possible genetic basis for heterogeneity adults how respond exercise. Two genes that have roles determining mass, young are angiotensin-converting enzyme (ACE) mitochondrial uncoupling protein 2 (UCP2). This study examined whether polymorphisms these two individual were associated with baseline...
Development of collateral circulation in coronary artery disease is cardio-protective. A key process forming new blood vessels attraction to occluded arteries monocytes with their subsequent activation as macrophages. In patients from a prospectively recruited post-acute syndromes cohort we investigated the prognostic performance three products activated macrophages, soluble vascular endothelial growth factor (VEGF) receptors (sFlt-1 and sKDR) pterins, alongside genetic variants VEGF...
The objective was to study the role of calpains in meat tenderness. Lambs were fasted for various periods time generate differences tenderness and determine tandem expression calpain 1, 2, 3, calpastatin. assumption has been that increased associated with an increase indicates a tenderization process vice versa. Fasting lambs 1 day caused significant improvement longissimus (LD) compared control. Correlations between LD calpastatin 3 but not 2 or Consequently, this supports from during...
The widespread use of emerging contaminants (ECs) may be compounding the problem antibiotic resistance. Various non-antibiotic pollutants have been shown to alter bacterial responses antibiotics and increase horizontal transfer antimicrobial resistance (AMR) genes. ECs include components medicines, foods, disinfectants, personal care products agrichemicals. concentrate in some environments such as wastewater, where pathogenic microorganisms mix. We investigated effects on gene nine one...
Abstract Calpastatin is the specific inhibitor of ubiquitous calcium‐dependent proteases μ‐calpain and m‐calpain. Enzyme assay data from sheep cattle inversely correlates post‐mortem muscle calpastatin levels with ultimate meat tenderness. Genetic markers quality may therefore be found linked to gene (CAST). A three‐allele system detected by polymerase chain reaction ‐ single strand conformational polymorphism (PCR‐SSCP) has been observed in ovine CAST. The three allele amplimers have fully...
A variant in the promoter of human uncoupling protein 2 (UCP2) gene, G-866A polymorphism, has been associated with future risk coronary heart disease events, those devoid traditional factors and suffering from diabetes. We thus examined impact polymorphism on 5-year survival a cohort 901 post-myocardial infarction patients, type-2 diabetes this relationship. The association UCP2 baseline biochemical hormonal measurements, including levels inflammatory marker myeloperoxidase, was also...
Soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF), components of the vascular endothelial (VEGF) system, play key roles in angiogenesis. Reports elevated plasma levels sFlt-1 PlGF coronary heart disease failure (HF) led us to investigate their utility, VEGF system gene single nucleotide polymorphisms (SNPs), as prognostic biomarkers HF.