A5002204022- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory and Cough-Related Research
- Long-Term Effects of COVID-19
- Vitamin D Research Studies
- Inhalation and Respiratory Drug Delivery
- Obstructive Sleep Apnea Research
- IL-33, ST2, and ILC Pathways
- COVID-19 diagnosis using AI
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sleep and related disorders
- Emergency and Acute Care Studies
- Pediatric health and respiratory diseases
- Neuroscience of respiration and sleep
- Immune Cell Function and Interaction
- Lung Cancer Diagnosis and Treatment
- T-cell and B-cell Immunology
- Autophagy in Disease and Therapy
- School Health and Nursing Education
Dubai Health Authority
2013-2024
Rashid Hospital
2012-2024
University of Sharjah
2014-2024
Dow University of Health Sciences
2023
Portsmouth Hospitals NHS Trust
2023
King's College Hospital
2023
Dubai Medical College
2023
University of British Columbia
2023
Khalifa University of Science and Technology
2022
United Arab Emirates University
2022
Insufficient blood levels of the neurohormone vitamin D are associated with increased risk COVID-19 severity and mortality. Despite global rollout vaccinations promising preliminary results, focus remains on additional preventive measures to manage COVID-19. Results conflict D's plausible role in preventing treating We examined relation between status mortality among multiethnic population United Arab Emirates. Our observational study used data for 522 participants who tested positive...
Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-κB) pathway regulate many cellular processes are essential for immune cells function. Their activity is controlled by dual-specificity phosphatases ( DUSPs ). A comprehensive analysis of publicly available gene expression data sets human airway epithelial (AECs) infected with SARS-CoV-2 identified DUSP1 DUSP5 among the lowest induced transcripts within these pathways. These proteins known to downregulate MAPK NF-κB pathways; their...
Coronavirus disease 2019 (COVID-19), originating in China, has rapidly spread worldwide. Physicians must examine infected patients and make timely decisions to isolate them. However, completing these processes is difficult due limited time availability of expert radiologists, as well limitations the reverse-transcription polymerase chain reaction (RT-PCR) method. Deep learning, a sophisticated machine learning technique, leverages radiological imaging modalities for diagnosis image...
The heterogeneity in symptomatology and phenotypic profile attributable to COVID-19 is widely unknown. objective of this manuscript conduct a trans-ancestry genome wide association study (GWAS) meta-analysis severity improve the understanding potentially causal targets for SARS-CoV-2.This cross-sectional recruited 646 participants UAE that were divided into two groups based on phenotypes, hospitalized (n=482) non-hospitalized (n=164) participants. Hospitalized patients developed acute...
As one of the current global health conundrums, COVID-19 pandemic caused a dramatic increase cases exceeding 79 million and 1.7 deaths worldwide. Severe presentation is characterized by cytokine storm chronic inflammation resulting in multi-organ dysfunction. Currently, it unclear whether extrapulmonary tissues contribute to mediated-disease exacerbation. In this study, we applied systems immunology analysis investigate immunomodulatory effects SARS-CoV-2 infection lung, liver, kidney, heart...
Ahmed Allehebi, Ameen Al-Omair, Bassam Mahboub, Coenraad F. Koegelenberg, Mohsen Mokhtar, Ashraf Mokhtar Madkour, Khaled Al-Asad, Ugur Selek, Humaid O. Al-Shamsi
Abstract Background No population study has explored the distribution of adult asthma in United Arab Emirates (UAE). The objective is to estimate prevalence general UAE. Methods Using standard European Community Respiratory Health Survey (ECRHS) questionnaires and tools, this a cross-sectional assessment random sample established quotas seven We surveyed 1,220 participants, which 63.2% were male, 20.1% UAE Nationals, with mean (SD) age 32.9 (14.1) years. Results Prevalence individual...
Fibrosis, particularly excessive collagen deposition, presents a challenge for treating asthmatic individuals. At present, no drugs can remove or reduce in airways. Hence, the identification of pathways involved deposition would help to generate therapeutic targets interfere with airway remodeling process. Autophagy, cellular degradation process, has been shown be dysregulated various fibrotic diseases, and genetic association studies independent human populations have identified...
Obesity is on the rise worldwide and one of most common comorbidities asthma. The chronic inflammation seen in obesity believed to contribute this process. Asthma are associated with a poorer prognosis, more frequent exacerbations, poor asthma control standard controller medication. Difficult-to-treat increased levels Th17 cytokines which have been shown play central role upregulation glucocorticoid receptor-beta (GR-β), dominant-negative inhibitor classical GR-α. In study, we studied IL-17...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious virus with overwhelming demand on healthcare systems, which require advanced predictive analytics to strategize COVID-19 management in more effective and efficient manner. We analyzed clinical data of 2017 cases reported the Dubai health authority developed models predict patient's length hospital stay risk death. A decision tree (DT) model was based patient information. The showed very good performance...
The United Arab Emirates (UAE) ranks 18th on the 2007 Forbes list of fattest countries with 68.3% its citizens an unhealthy weight and it is well known that gain obesity are important determinants in progression obstructive sleep apnea syndrome (OSAS). purpose this study to estimate prevalence symptoms risk OSAS primary health care setting Dubai, relationship between apnea.In prospective survey, a trained medical nurse administered Berlin Questionnaire consecutive random sample patients age...
T-helper 17 cell-mediated response and their effector IL-17 cytokine induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a major cause of COVID-19 disease severity death. Therefore, the study aimed to determine if level in saliva mirrors its circulatory hence can be used as non-invasive biomarker for severity.Interleukin-17 (IL-17) was evaluated ELISA blood 201 adult patients with different levels severity. The also associated severity, need mechanical...
The accumulation of fibroblasts, their synthesis extracellular matrix (ECM) proteins and innate resistance to apoptosis are characteristics subepithelial fibrosis observed in severe asthma. Interleukin-17 (IL-17) is an important regulator airway remodeling However, the contribution IL-17 pro-fibrotic phenotype bronchial fibroblasts not well characterized. In this study, we investigated whether induced autophagy regulates mitochondrial function fibroblasts. primary cultured isolated from...
Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin status with severity of COVID-19. Genetic variants involved metabolism been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations humans affected clinical presentation In total, 646 patients SARS-CoV-2 infection were divided into two groups: noncritical (
SARS-CoV-2 appears to induce diverse innate and adaptive immune responses, resulting in different clinical manifestations of COVID-19. Due their function presenting viral peptides initiating the response, certain Human Leucocyte Antigen (HLA) alleles may influence susceptibility severe infection. In this study, 92 COVID-19 patients from 15 nationalities, with mild (n = 30), moderate 35), 27) infection, living United Arab Emirates (UAE) were genotyped for Class I HLA -A, -C, -B using...