A5101473145- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Opioid Use Disorder Treatment
- Sex work and related issues
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Prenatal Substance Exposure Effects
- COVID-19 epidemiological studies
- Substance Abuse Treatment and Outcomes
- Forensic Toxicology and Drug Analysis
- Criminal Justice and Corrections Analysis
- Adolescent Sexual and Reproductive Health
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Impact and Responses
- Homelessness and Social Issues
- Alcohol Consumption and Health Effects
- Pharmacovigilance and Adverse Drug Reactions
- COVID-19 Digital Contact Tracing
- Meteorological Phenomena and Simulations
- Intramuscular injections and effects
- Advanced Causal Inference Techniques
- Healthcare Systems and Public Health
- Psychopathy, Forensic Psychiatry, Sexual Offending
University of Bristol
2016-2025
Pennsylvania State University
2025
National Institute for Health Research
2022-2023
NIHR Bristol Biomedical Research Centre
2019-2022
People who have recently injected drugs are a priority population in efforts to achieve hepatitis C virus (HCV) elimination. This study estimated the prevalence and number of people with recent injecting drug use living HCV, proportion among all HCV infection at global, regional country-levels.Data from global systematic review antibody (previous year) were used estimate HCV. These data combined HCV.There an 6.1 million [95% uncertainty interval (UI) = 3.4-9.2] aged 15-64 years globally...
People who inject drugs (PWID) experience high incarceration rates, and previous is associated with elevated hepatitis C virus (HCV) transmission risk. In Scotland, national survey data indicate lower HCV incidence in prison than the community (4.3 versus 7.3 per 100 person-years), but a 2.3-fold risk among recently released (< 6 months) PWID. We evaluated contribution of to PWID impact prison-related prevention interventions, including scaling-up direct-acting antivirals (DAAs)...
Abstract Introduction In generalized epidemic settings, there is insufficient understanding of how the unmet HIV prevention and treatment needs key populations (KPs), such as female sex workers (FSWs) men who have with (MSM), contribute to transmission. it typically assumed that transmission driven by general population. We estimated contribution commercial sex, between men, other heterosexual partnerships in South Africa (SA). Methods developed “Key‐Pop Model”; a dynamic model among FSWs,...
Drug-related death (DRD) rate in Scotland, UK, has increased rapidly to one of the highest world. Our aim was examine extent which opioid-agonist therapy (OAT) Scotland is protective against drug-related mortality and how this effect varied over time.
People who inject drugs (PWID) are a priority population in HCV elimination programming. Overcoming sex and gender disparities risk, prevention, the cascade of care is likely to be important achieving this goal, but these have not yet been comprehensively reviewed.
Hepatitis C virus (HCV) elimination is being seriously considered globally. Current models require a combination of highly effective HCV treatment and harm reduction, but high costs make such strategies prohibitively expensive. Vaccines should play key role in their best use alongside treatments unclear. For three vaccines with different efficacies we used mathematical model to estimate the additional reduction prevalence when vaccinating after treatment; identify which settings could most...
BackgroundA considerable proportion of people who inject drugs are unstably housed. Although unstable housing is associated with HIV and HCV infection among drugs, its contribution to transmission unknown. We estimated the global national proportions incident infections attributed instability from 2020 2029.MethodsIn this modelling study, we developed country-level models in 58 countries globally, calibrated country-specific data on prevalences housing. Based a recently published systematic...
Key populations (KPs), including female sex workers (FSWs), gay men and other who have with (MSM), people inject drugs (PWID), transgender women (TGW) experience disproportionate risks of HIV acquisition. The UNAIDS Global AIDS 2022 Update reported that one-quarter all new infections occurred among their non-KP sexual partners. However, this fraction relied on heuristics regarding the ratio KPs transmitted to partners acquired (herein referred as "infection ratios"). We recalculated these...
The distribution of new HIV infections among key populations, including female sex workers (FSWs), gay men and other who have with (MSM), people inject drugs (PWID) are essential information to guide an response, but data limited in sub-Saharan Africa (SSA). We analyzed empirically derived mathematical model-based estimates incidence populations compared the Joint United Nations Programme on HIV/AIDS (UNAIDS) estimates.
Abstract North American Cold Air Outbreaks (CAOs) are large-scale temperature extremes that typically originate in the high latitudes and impact midlatitudes winter. As they transit southward, can have significant socioeconomic consequences. CAOs from winter (DJF) 1979 to 2020 were identified European Center for Medium-Range Weather Forecasts reanalysis dataset (ERA5) using an automated feature tracking approach (TempestExtremesV2.1). This allowed systematic identification of a large number...
Background Supervised injecting facilities (SIFs) are designed to reduce the harms associated with drug use and improve access health support services for people who need them. The Injecting Room Cohort Study (SIRX) aims provide evidence of effects, including cost-effectiveness, a SIF embedded within community service, Melbourne Medically (MSIR), which has range integrated harm reduction, social on-site. Methods analysis SIRX study design involves two prospective cohort studies that collect...