Nicolas Clark

ORCID: 0000-0001-8697-6183
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About
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Research Areas
  • Opioid Use Disorder Treatment
  • Substance Abuse Treatment and Outcomes
  • Forensic Toxicology and Drug Analysis
  • HIV, Drug Use, Sexual Risk
  • Spine and Intervertebral Disc Pathology
  • Surface and Thin Film Phenomena
  • Hydrogen Storage and Materials
  • Advanced Chemical Physics Studies
  • Physics of Superconductivity and Magnetism
  • Medical Imaging and Analysis
  • Cardiac, Anesthesia and Surgical Outcomes
  • Spinal Fractures and Fixation Techniques
  • Mental Health Treatment and Access
  • Health Policy Implementation Science
  • Hepatitis C virus research
  • Health Systems, Economic Evaluations, Quality of Life
  • Magnetic properties of thin films
  • Prenatal Substance Exposure Effects
  • HIV/AIDS Research and Interventions
  • Schizophrenia research and treatment
  • Liver Disease Diagnosis and Treatment
  • Psychedelics and Drug Studies
  • Ammonia Synthesis and Nitrogen Reduction
  • Forensic Fingerprint Detection Methods
  • Hepatitis B Virus Studies

St Vincent's Hospital
2003-2025

Burnet Institute
2025

Thomas Jefferson University
2025

Naples Community Hospital Healthcare System
2025

Hospital for Special Surgery
2025

The University of Queensland
2021-2024

The Royal Melbourne Hospital
2020-2024

Madison County Health Department
2019-2023

RELX Group (Netherlands)
2023

The University of Adelaide
2021-2022

Abstract Background and Aims The World Health Organization ( WHO ), a growing number of other organizations, have adopted the G rading R ecommendations, A ssessment, D evelopment E valuation GRADE ) system in order to both assess quality research evidence develop clinical practice guidelines. In 2009 published guideline on psychosocially assisted pharmacological treatment opioid dependence, based results C ochrane eviews summarized using methodology. main features this are an priori...

10.1111/add.12788 article EN Addiction 2014-12-10

Neurosurgeons lack precise insights into the true costs of transsphenoidal endoscopic surgery for sellar and suprasellar lesions (TESS), including pituitary adenomas, craniopharyngiomas, apoplexy. To address this critical knowledge gap, we employ time-driven activity-based costing (TDABC) TESS. We analyzed 221 TESS procedures performed between 2017 2022 at a large academic medical center. Costs were calculated using TDABC. Software was developed to extract information regarding all resources...

10.1016/j.wneu.2025.123792 article EN cc-by World Neurosurgery 2025-03-20

Abstract Aims To examine indicators of buprenorphine diversion and injection among injecting drug users in Melbourne, Australia to determine the factors associated with injection. Design Melbourne arm 2002 Illicit Drug Reporting System (IDRS) cross‐sectional study. Setting Five Needle Syringe Programme sites Australia. Participants A total 156 current (IDU). Study elibility criteria were at least monthly during previous 6 months, residence for preceding 12 months. Measurements Structured...

10.1111/j.1360-0443.2004.00958.x article EN Addiction 2005-01-28

Corrado Barbui and colleagues describe their use adaptation of the GRADE approach in developing guidelines for WHO mental health Gap Action Programme (mhGAP).

10.1371/journal.pmed.1000322 article EN cc-by PLoS Medicine 2010-08-31

The increasing prevalence of obesity has raised concerns about its impact on surgical outcomes and healthcare costs. This study evaluates the influence Body Mass Index (BMI) intraoperative costs operative times during open Transforaminal Lumbar Interbody Fusion (TLIF) procedures using a Time-Driven Activity-Based Costing (TDABC) approach. A retrospective analysis was conducted 279 patients who underwent TLIF between 2019 2022. Patients were categorized into 5 BMI cohorts: healthy weight (BMI...

10.1016/j.xnsj.2025.100583 article EN cc-by-nc-nd North American Spine Society Journal (NASSJ) 2025-01-18

Abstract Background Information on infectious complications following acute severe ulcerative colitis (ASUC) is limited. The aim of this study was to determine rates infections ASUC treatment and the associated risk factors, using data from Asian Organization for Crohn’s Colitis (AOCC) Australia New Zealand IBD Consortium (ANZIBDC). Methods We collected medical records patients diagnosed with according Truelove Witts criteria January 2015 December 2022 across AOCC ANZIBDC. analyzed...

10.1093/ecco-jcc/jjae190.0401 article EN Journal of Crohn s and Colitis 2025-01-01

Abstract Background There are limited comparisons of clinical outcomes acute severe ulcerative colitis (ASUC) between East Asian (EA) and Western countries many currently used scoring systems based on populations. We developed a predictive model using ASUC data from EA patients assessed its ability to predict in an Australia/New Zealand (ANZ) cohort. Methods This retrospective international study was conducted across 23 referral hospitals ANZ. Patients who met Truelove Witts criteria for...

10.1093/ecco-jcc/jjae190.0082 article EN Journal of Crohn s and Colitis 2025-01-01

Background Supervised injecting facilities (SIFs) are designed to reduce the harms associated with drug use and improve access health support services for people who need them. The Injecting Room Cohort Study (SIRX) aims provide evidence of effects, including cost-effectiveness, a SIF embedded within community service, Melbourne Medically (MSIR), which has range integrated harm reduction, social on-site. Methods analysis SIRX study design involves two prospective cohort studies that collect...

10.1136/bmjopen-2024-091337 article EN cc-by-nc-nd BMJ Open 2025-02-01

Inspired by Locard's exchange principle, which states "every contact leaves a trace", trace residue sampling strategy has been developed for the analysis of discarded drug packaging samples (DPS), as part an early warning system illicit use at large public events including music/dance festivals. Using direct in real time/mass spectrometry and tandem mass spectrometry, rapid high-throughput identification characterization wide range drugs adulterant substances was achieved, complex polydrug...

10.1021/jasms.1c00232 article EN Journal of the American Society for Mass Spectrometry 2021-08-30

Buprenorphine was registered in Australia as a maintenance and detoxification agent for the management of opioid dependence November, 2000, became widely available August, 2001. This paper provides an overview key developments introduction buprenorphine treatment Australia, with emphasis upon delivery services community-based (primary care) settings. A central study this work Implementation Trial (BIT), randomized, controlled trial comparing methadone delivered under naturalistic conditions...

10.1080/10550490490440799 article EN American Journal on Addictions 2004-04-16

OBJECTIVES: To describe the prevalence of risk factors for abuse and newborns’ risks physical hospitalizations during early infancy. METHODS: We created a nationally representative US birth cohort using 2013 2014 Nationwide Readmissions Databases. Newborns were characterized by demographics, prematurity or low weight (LBW), intrauterine drug exposure, medical complexity (including defects). tracked 6 months from their hospitalization, subsequent identified International Classification...

10.1542/peds.2018-2108 article EN PEDIATRICS 2019-01-25

Very little evidence has been reported in literature regarding the misuse of substances rural areas. Despite common perception communities as a protective and risk-mitigating environment, scientific demonstrated existence many risk factors communities. The Drug Prevention Health Branch (DHB) United Nations Office on Drugs Crime (UNODC), World Organization (WHO), June 2016, organized meeting experts treatment prevention SUDs settings. content presented during related discussion have provided...

10.1080/10826084.2017.1306564 article EN Substance Use & Misuse 2017-06-12

The current phase of the North American 'opioid crisis' is characterised by illicit fentanyl use; however, presence in Australia unknown. This study aimed to monitor unintentional consumption Australia.Rapid urine drug screens (UDS) paired with surveys conducted within supervised injecting facilities (SIFs) and confirmatory laboratory testing.Sydney Melbourne, Australia.Clients who used heroin past 2 days (n = 911 tests, 2017-2021). Participants were demographically similar overall client...

10.1111/add.15832 article EN cc-by-nc-nd Addiction 2022-02-07
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