A5080588658- Pharmaceutical studies and practices
- Pharmaceutical Practices and Patient Outcomes
- Pharmacovigilance and Adverse Drug Reactions
- Child and Adolescent Health
- Pediatric Pain Management Techniques
- Patient Safety and Medication Errors
- Ethics and Legal Issues in Pediatric Healthcare
- Pharmaceutical Economics and Policy
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Anesthesia and Sedative Agents
- Childhood Cancer Survivors' Quality of Life
- Cytokine Signaling Pathways and Interactions
- Healthcare Systems and Technology
- 3D Printing in Biomedical Research
- Computational Drug Discovery Methods
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Academic integrity and plagiarism
- Urticaria and Related Conditions
- Pharmacology and Obesity Treatment
- Myofascial pain diagnosis and treatment
- Epilepsy research and treatment
- Adrenal Hormones and Disorders
- Obesity and Health Practices
St Vincent's Hospital Sydney
2025
Alder Hey Children's NHS Foundation Trust
2014-2024
Eaton (Taiwan)
2022
Southern Utah University
2020
University of Liverpool
2016-2018
National Health Service
2014
Off-label and unlicensed (OLUL) prescribing has been prevalent in pediatric practice. Using data from a prospective cohort study of adverse drug reactions (ADRs) among inpatients, we aimed to test the hypothesis that OLUL status is risk factor for ADRs. A nested case?control was conducted within study. Details all medicines administered were recorded, including information about status. The odds ratio being implicated probable or definite ADR calculated. multivariate Cox proportional hazards...
Adverse drug reactions (ADRs) are an important cause of harm in children. Current data incomplete due to methodological differences between studies: only half all studies provide data, incidence rates vary (0.6% 16.8%) and very few on causality, severity risk factors pediatric ADRs. We aimed determine the ADRs hospitalized children, characterize these terms type, etiology, causality identify factors. undertook a year-long, prospective observational cohort study admissions single UK medical...
Abstract Background There are limited comparisons of clinical outcomes acute severe ulcerative colitis (ASUC) between East Asian (EA) and Western countries many currently used scoring systems based on populations. We developed a predictive model using ASUC data from EA patients assessed its ability to predict in an Australia/New Zealand (ANZ) cohort. Methods This retrospective international study was conducted across 23 referral hospitals ANZ. Patients who met Truelove Witts criteria for...
Aims To comprehensively investigate the incidence, nature and risk factors of adverse drug reactions (ADRs) in a hospital-based population children, with rigorous assessment causality, severity avoidability, to assess consequent impact on children families. We aimed improve ADRs by development new tools causality minimise families developing better strategies for communication. Review methods Two prospective observational studies, each over 1 year, were conducted associated admission...
To develop and test a new tool to assess the avoidability of adverse drug reactions that is suitable for use in paediatrics but which also applicable variety other settings.The study involved multiple phases. Preliminary work using Hallas scale modification existing scale, two different sets reaction (ADR) case reports. Phase 1 defined, modified refined multidisciplinary teams. 2 assessment 50 ADR reports from prospective paediatric inpatients by individual assessors. 3 compared assessments...
Objective Feasibility study to investigate the acceptability of different-sized placebo tablets in children aged 4–12 years. Design and setting Clinical Research Facilities, inpatient wards outpatient clinics within a Regional Paediatric Hospital and/or District General Hospital. Healthy National Health Service (NHS) patients were asked swallow three tablets: 6 mm, 8 mm 10 smallest largest. The researcher observed children’s facial expressions behaviours on swallowing measured volume water...
3D printing (3DP) has been proposed as a novel approach for personalising dosage forms children and young people (CYP). Owing to its low cost the lack of need finishing steps, fused deposing modelling (FDM) 3DP heavily researched in solid (SDFs) manufacturing. However, swallowability overall acceptability printed are yet be established. This work is first evaluate different sized placebo SDFs CYP (aged 4-12 years). All participants had previously participated feasibility study (CAT study)...
Abstract The use of antimicrobials (AMs) in pediatric infections is common practice and may be inappropriate leading to antimicrobial resistance. Off-label AM also this group can result drug-related problems. There lack DUR data Brazil Latin America, specially for use. aim study was describe the utilization AMs hospitalized children five hospitals Brazil. We conducted an observational wards states Ceará (CE), Sergipe (SE), Rio de Janeiro (RJ), Grande do Sul (RS) Federal District (DF). Data...
Children are more exposed to inappropriate medicines use and its harms. Spontaneous reporting of suspected Serious Adverse Drug Reactions (SADRs) increases knowledge prevention pharmacotherapy risk. Disproportionality measures useful quantify unexpected safety issues associated with a given drug-event pair (signals disproportionality). This cross-sectional study aimed assess SADRs signals for Brazilian children 0-12 years old notified between January 2008 December 2013 from the system...
Antibiotics are among the most commonly prescribed drugs in children. Adherence to treatment with these is of utmost importance prevent emergence resistant bacteria, a global health threat. In children, medicine acceptability likely have significant impact on compliance. Herein we used multivariate approach, considering simultaneously many aspects explore drivers oral antibiotic children under twelve, especially toddlers and preschoolers. Based 628 real-life observer reports intake 133...
To better understand the factors that facilitate and hinder a positive experience of paediatric outpatient parenteral antimicrobial therapy (OPAT).Qualitative study using semistructured interviews.A dedicated consultant-led hospital-based, outreach OPAT service in England.Participants were primarily parents children who had received OPAT; one child participated.Children participated survey phase larger invited to be interviewed.12 (10 mothers 2 fathers) 10 participated; (aged 15 years). Data...
Little evidence exists about parental satisfaction and their influence on referral to paediatric Outpatient Parenteral Antimicrobial Therapy (OPAT).This study aimed examine the experiences of parents, children clinicians OPAT at a large tertiary children's hospital.A prospective e-survey, using closed open questions, parents (n = 33) 33 who had received (3 completed survey), 31) involved in hospital. Data were collected September 2016 July 2018.Data analysed simple descriptive statistics....
To describe how individual schools manage medicines and strategies for implementation of guidance, to determine the nature problems perceived by children, parents, teachers healthcare professionals (HCPs) in relation management highlight differences between these perceptions.A cross-sectional survey study which questionnaires were completed their parents carers, groups HCPs head teachers.There 158 respondents this survey. The varies reflects policy guidance is interpreted revealed experience...
Evidence supporting personalised treatment for asthma based on an individual's genetics is mounting. The views of children and young people (CYP), parents healthcare professionals (HCPs) about this evolution clinical care are not known.A pilot prospective questionnaire-based study was undertaken CYP with asthma, their HCPs at a secondary/tertiary children's hospital in the UK.Fifty-nine questionnaires were distributed 50 returned (response rate 84.7%), comprising 26 (10 5-11 years, 11 12-15...
Medicines designed for adults may be inappropriate use in children terms of strength, dosage form and/or excipient content. There is currently no standardised method assessing the age-appropriateness a medicine paediatric use. To develop and test tool to assess whether (formulation) appropriate estimate proportion formulations considered 'inappropriate' cohort hospitalised patients with chronic illness. A multi-phase study: patient data collection, development, case assessments validation....
Abstract Background Children are more vulnerable to adverse drug reactions (ADRs) due complex changes in the body during growth process and lack specific pharmacoepidemiologic studies. Causality Avoidability assessment of ADRs relevant clinical guidelines development pharmacovigilance. This study aimed translate transcultural adapt two new tools—Liverpool Assessment Tool (LCAT) Liverpool (LAAT)—to Brazilian-Portuguese evaluate psychometric properties these tools analyse Brazilian children....
<h3>Aim</h3> The aim of this study was to gather the views primary care healthcare professionals (HCPs) on issues faced by parents/carers babies discharged home with medication from neonatal units in UK. This information will be used compare and expand findings data collected HCPs secondary which highlighted challenges that may arise during process. <h3>Method</h3> A stakeholder map created pharmacist support project leads. previous e-survey for amended applicable care.<sup>1</sup> primarily...
Objective This study aimed to assess the number of prescriptions that were uncollected by caregivers identify any predisposing systemic themes may act as barriers children receiving medications. Study design and setting Data retrospectively collected on at a single, tertiary paediatric centre over 2-month period. included type classification drug, prescriber specialty, timing prescription child’s registered postcode. Key identified. Results A total 124 involving 94 patients included. 103...