A5011135723- Pharmaceutical studies and practices
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Medication Adherence and Compliance
- Pharmaceutical Economics and Policy
- Child and Adolescent Health
- Antibiotic Use and Resistance
- Sensory Analysis and Statistical Methods
- Cell Adhesion Molecules Research
- Olfactory and Sensory Function Studies
- Statistical Methods in Clinical Trials
- Child Nutrition and Feeding Issues
- Biochemical Analysis and Sensing Techniques
- Pediatric Pain Management Techniques
- Dysphagia Assessment and Management
- Respiratory and Cough-Related Research
- Cancer Cells and Metastasis
- Dental Anxiety and Anesthesia Techniques
- Attention Deficit Hyperactivity Disorder
- Health Sciences Research and Education
- Pharmacological Effects and Toxicity Studies
- Infant Health and Development
- Computational Drug Discovery Methods
- Caveolin-1 and cellular processes
- Pediatric Urology and Nephrology Studies
Monal Group (France)
2016-2023
Laboratoire Conception de Produits et Innovation
2016-2018
ParisTech
2016-2018
École de Biologie Industrielle
2016
The purpose of this article was to present an original standardized tool assessing the medicine's acceptability whichever their characteristics and patient features.An map built with objective measures from medicine use assessments collected in real-life conditions. Multiple correspondence analysis (MCA) used for mapping process. Hierarchical classification on principal components (HCPC) MCA performed clustering process corresponding distinct profiles.The results presented here focus 234...
Presenting many advantages, solid oral dosage forms (SODFs) are widely manufactured and frequently prescribed in older populations regardless of the specific characteristics patients. Commonly, patients with dysphagia (swallowing disorders) experience difficulties taking SODFs, which may lead to non-adherence or misuse. SODF (e.g., size, shape, thickness) likely influence swallowability. Herein, we used acceptability reference framework (the ClinSearch score test (CAST))—a 3D-map juxtaposing...
Although knowledge on medicine acceptability remains fragmented, this multi-faceted concept has emerged as a key factor for compliance in pediatrics. In order to investigate the of medicines used University Medical Centre Ibn Sina (CHIS) Rabat, Morocco, an observational study was conducted. Using multivariate approach integrating many aspects acceptability, standardized observer reports were collected 570 intakes patients up age 16, then analyzed reference framework. Tablets appeared be well...
Although medicine acceptability is likely to have a significant impact on the patient's adherence in pediatrics and therefore therapy success, there still little data even for common therapeutic areas. For analgesics/antipyretics, healthcare professionals face wide variety of products need knowledge select best adapted product each patient. We investigated those most used at University Children's Hospital Düsseldorf, Germany. Based 180 real-life observer reports intake, we reference...
In institutional care, oral liquid pharmaceutical products are widely prescribed for older patients, especially those with swallowing disorders. As medicines acceptability is a key factor compliance in the population, this study investigated of targeted population.An observational, multicenter, prospective was conducted eight geriatric hospitals and nursing homes France. Observers reported several behaviours/events describing many aspects various products' uses patients aged 65 older....
Medicines can be taken by various routes of administration. These impact the effects and perceptions medicines. The literature about individuals' preferences for different administration is sparse, but indicates a potential influence culture. Our aim was to determine: (i) any association between one's culture preferred route medicine (ii) individual pain, efficacy, speed action acceptability when medicines are swallowed or placed in mouth, under tongue, nose, eye, ear, lungs, rectum, vagina,...
Our novel tool to standardise the evaluation of medicine acceptability was developed using observational data on medicines use measured in a paediatric population included for this purpose (0-14 years). Using tool, any may be positioned map and assigned an profile. The present exploration aimed verify its statistical reliability.
Medicine acceptability, which is of the utmost importance for vulnerable patients' adherence, driven by both user and product characteristics. Herein, a novel multivariate approach integrating many aspects acceptability used to discriminate positively negatively accepted medicines in older population. An observational study was carried out eight hospitals nursing homes collect large set real-life data on uses patients (≥65 years). Mapping clustering explored these multiple measures...
Introduction Medicine acceptability is a multi-faceted concept driven by both product and user characteristics. Although key factor for treatment effectiveness, especially in vulnerable populations, knowledge of those medicine features that best promote individual remains fragmented. Focusing on paracetamol, this study has explored the appropriateness pharmaceutical products different dosage forms to achieve adequate patient from infants centenarians. Methods This observational, multicentre,...
It is well established that treatment regime compliance linked to the acceptability of a pharmaceutical formulation, and hence also therapeutic outcomes. To end, must be assessed during development all products especially for those intended paediatric patients. Although multifaceted concept, poor sensory characteristics often contribute patient acceptability. In particular, taste cited as major reason many patients, children, refuse take their medicine. thus important understand and, far...
Antibiotics are among the most commonly prescribed drugs in children. Adherence to treatment with these is of utmost importance prevent emergence resistant bacteria, a global health threat. In children, medicine acceptability likely have significant impact on compliance. Herein we used multivariate approach, considering simultaneously many aspects explore drivers oral antibiotic children under twelve, especially toddlers and preschoolers. Based 628 real-life observer reports intake 133...
Objective The understanding of acceptability existing dosage forms is limited in most the world and hinders development acceptable, age‐appropriate medicines. attributes paediatric medicine may differ from country to based on culture, healthcare infrastructure health policies. This study was designed map oral medicines patients treated hospital India. Methods An observational, cross-sectional conducted aged below 18 years taking any form medication. Acceptability scores were obtained using...
Palatability is a recognized driver of medicine acceptability in pediatrics but deemed less relevant older populations due to sensory decline. Preliminary findings from an observational study implicated palatability problems with one Alzheimer’s medicine. Among 1517 observer reports combining multiple measures on medicines uses patients aged over 64, we focused two original formulations memantine (Ebixa®, tablets (n = 25) and oral solution 60)). Evaluations were scored reference framework...
In pediatrics, acceptability has emerged as a key factor for compliance, and consequently treatment safety efficacy. Polyvalent mechanical bacterial lysate (PMBL) in 50-mg sublingual tablets is indicated children adults the prophylaxis of recurrent respiratory tract infections. This medication may be prescribed over 3 years age; appropriateness this formulation should thus demonstrated amongst young children. Using multivariate approach integrating many aspects acceptability, standardized...
Urinary tract infection (UTI) is a common health care-associated adverse event and the leading nosocomial complication following pediatric urological surgery. While continuous antimicrobial prophylaxis effectively reduces risk of UTI such surgery, non-adherence represents distinct clinical entity that associated with renal scarring. Acceptability likely to have significant impact on patient adherence. Herein we used validated data-driven approach—the ClinSearch acceptability score test...
Although drug acceptability can have a significant impact on patient adherence in pediatric therapy, data are limited, even for common therapeutic areas. We present the second part of an study conducted at University Children's Hospital Düsseldorf, Germany. The investigated most commonly used antibiotics hospital setting. researchers reference framework to score five based 150 real-life observer reports medicine intake. Four assessed this were formulated as preparations injection...
Medicines acceptability is likely to have a significant impact on older people's adherence and, consequently, treatment effectiveness. The objective was explore the influence of setting medicines in people.A multi-centre, prospective, cross-sectional, observational study conducted one care home and elderly hospital ward London, UK, involving individuals ≥1 medicine(s) aged ≥65 years. Data-driven approach applied using multiple observer-reported outcomes analysis tool distinguish between...
Soil-transmitted helminthiasis (STH) is among the most common of parasitic infections, affecting vulnerable populations in tropical/subtropical areas globally. In endemic countries, children, a high-risk population, require treatment and preventive interventions. Mebendazole, WHO-recommended medicine, originally formulated as tablet that was often crushed for administration to young children unable swallow it, reformulated chewable tablet. Acceptability key aspect effectiveness pediatrics....
Abstract Chemical submission is increasing by an occurring phenomenon that consists in administering psychoactive substances for criminal intent to unaware victim. This diversion usually achieved adding a drug the drink of potential study aims essentially at providing sensory method would allow detection changes due drug. The complexity this stemmed from large number beverages and drugs can be used ill‐intentioned act. alcoholic soft drinks studied here were selected as result on‐line...