A5066182911- Biochemical Analysis and Sensing Techniques
- Pharmaceutical studies and practices
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Ion Transport and Channel Regulation
- Pain Management and Placebo Effect
- Electrolyte and hormonal disorders
- Drug Solubulity and Delivery Systems
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Asthma and respiratory diseases
University College London
2018-2023
University College Lahore
2019
Medway School of Pharmacy
2018
Taste is crucial for patient acceptability and compliance with prescribed medicines, in particular pediatric patients. Evaluating the taste of new active pharmaceutical ingredients (APIs) therefore essential to put place adequate taste-masking techniques, if needed, which will lead acceptable palatable formulations. Thus, there an urgent need develop optimize assessment methods that could be used at different stages drug development process. The aim this study was investigate suitability rat...
Medicines for children often taste bitter, presenting a significant challenge to treatment compliance. However, most studies on paediatric drug development rely adult volunteers sensory research, and the level of expertise required from these assessors is unclear. This study aimed address this gap by investigating perceived bitterness aversion strips impregnated with different concentrations quinine hydrochloride in 439 school-aged children. Expert (n=26) naïve (n=65) young evaluated...
Spironolactone (SPL), a potent anti-aldosterone steroidal drug used to treat several diseases in paediatric patients (e.g., hypertension, primary aldosteronism, Bartter's syndrome, and congestive heart failure), is not available child-friendly dosage forms, spironolactone liquids have been reported be unpalatable. Aiming enhance SPL solubility aqueous solution overcome palatability, herein, the effects of (2-hydroxypropyl)-β-cyclodextrin (HP-β-CyD) were thoroughly investigated on...
The majority of active pharmaceutical ingredients (APIs) are bitter. Therefore, compliance can be a problem where adequate taste masking has not been achieved; this is most problematic in pediatrics. Taste thus key stage during development with an array strategies available to the formulation scientist. Solid oral dosage forms taste-masked quite simply by polymer coating, which prevents drug release mouth, without unwantedly impairing further down gastrointestinal tract. At early stages...
Palatability is a recognized driver of medicine acceptability in pediatrics but deemed less relevant older populations due to sensory decline. Preliminary findings from an observational study implicated palatability problems with one Alzheimer’s medicine. Among 1517 observer reports combining multiple measures on medicines uses patients aged over 64, we focused two original formulations memantine (Ebixa®, tablets (n = 25) and oral solution 60)). Evaluations were scored reference framework...