A5049324932- Pharmaceutical studies and practices
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Health Systems, Economic Evaluations, Quality of Life
- Pediatric Pain Management Techniques
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Advanced Chemical Sensor Technologies
- Medication Adherence and Compliance
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical Economics and Policy
- Adolescent and Pediatric Healthcare
- Microscopic Colitis
- Child Nutrition and Feeding Issues
- Childhood Cancer Survivors' Quality of Life
- Inhalation and Respiratory Drug Delivery
- Gastrointestinal motility and disorders
- Child and Adolescent Health
- Anatomy and Medical Technology
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Augmented Reality Applications
- Sensory Analysis and Statistical Methods
- Clinical Nutrition and Gastroenterology
- Additive Manufacturing and 3D Printing Technologies
University College London
2013-2024
3D printing (3DP) in the pharmaceutical field is a disruptive technology that allows preparation of personalised medicines at point dispensing. The paediatric population presents variety formulation challenges such as dose flexibility, patient compliance, taste masking and fear or difficulty to swallow tablets, all factors could be overcome using adaptable nature 3DP. User acceptability studies printed formulations have been previously carried out adults; however, feedback from children...
Orodispersible films (ODFs) possess potential to facilitate oral drug delivery children; however, documentation of their acceptability in this age group is lacking. This study the first explore initial perceptions, and ease use ODFs for infants preschool children, caregivers through observed administration type dosage form. Placebo were administered children stratified into aged 6 12 months, 1 year, 2 years, 3 4 years 5 old those with an acute illness or long-term stable condition hospital...
Primaquine is an important antimalarial drug for malaria transmission blocking and radical cure, but it not currently available in child-friendly formulations appropriate doses. Adult-strength tablets are often crushed dissolved water to obtain the required dose, which exposes drug's bitter taste. As part of developing paediatric primaquine (DPP) project, this study adopted a responsive sensory pharmaceutics approach by integrating real-time formulation development pre-clinical taste...
Medicines for children often taste bitter, presenting a significant challenge to treatment compliance. However, most studies on paediatric drug development rely adult volunteers sensory research, and the level of expertise required from these assessors is unclear. This study aimed address this gap by investigating perceived bitterness aversion strips impregnated with different concentrations quinine hydrochloride in 439 school-aged children. Expert (n=26) naïve (n=65) young evaluated...
Pediatric pharmacists are constantly faced with the challenges of supporting children and caregivers for whom difficulties swallowing medicines can be a daily struggle. Most only available as tablets capsules, where liquid alternatives exist, these products often have issues palatability high costs. The objective this study was to evaluate whether spray, Pill Glide, could help in taking their solid medicines. This open label pilot compared spray behavioral approach alone, current standard...
For orally administered drugs, palatability is key in ensuring patient acceptability and treatment compliance. Therefore, understanding children’s taste sensitivity preferences can support formulators making paediatric medicines more acceptable. Presently, we explore if the application of computer-vision techniques to videos reaction gustatory strips provide an objective assessment palatability. Children aged 4 11 years old tasted four different flavoured strips: no taste, bitter, sweet,...
<h3>Aims</h3> The 2007 EU 'Paediatric Regulation' has been a regulatory milestone governing the development and authorisation of medicines for use in children. Children have specific requirements which must be considered when developing prescribing medicines, yet there is lack evidence-based information on dosage forms choice. Children9s acceptability oral formulations project aims to survey children their carers9 perspectives practices using solid forms, with view support both industrial...
Abstract For orally administered drugs, palatability is key in ensuring patient acceptability and treatment compliance. Therefore, understanding children’s taste sensitivity preferences can support formulators making paediatric medicines more acceptable. Presently, we explore if the application of computer-vision techniques to videos reaction gustatory strips provide an objective assessment palatability. Primary school children tasted four different flavoured strips: no taste, bitter, sweet...