A5076982441- Gastrointestinal motility and disorders
- Drug Solubulity and Delivery Systems
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Glaucoma and retinal disorders
- Clostridium difficile and Clostridium perfringens research
- Pharmaceutical studies and practices
- Gut microbiota and health
- Microscopic Colitis
- Intestinal and Peritoneal Adhesions
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Drug Transport and Resistance Mechanisms
- Diet and metabolism studies
- Inflammatory Bowel Disease
- Digestive system and related health
- Crystallization and Solubility Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Potassium and Related Disorders
- Corneal Surgery and Treatments
- Protease and Inhibitor Mechanisms
- Polymer Science and PVC
- Analytical Chemistry and Chromatography
- Clinical Nutrition and Gastroenterology
- Retinal Diseases and Treatments
Butler University
2013-2024
International Pharmaceutical Federation
2024
University College London
2010-2020
Purdue University West Lafayette
2014-2015
Moorfields Eye Hospital NHS Foundation Trust
2013
Moorfields Eye Hospital
2010-2012
The London College
2012
University College Lahore
2012
University of London
2005-2011
St George's Hospital
2010
The purpose of this work was to study the solubility two drugs with different physicochemical properties in luminal fluids obtained from various regions human gastrointestinal (GI) tract and determine most important parameters influencing their solubility. Jejunal were aspirated healthy volunteers via an oral intubation tube. Ileal colonic patients undergoing GI surgery. Stoma also retrieved patients. pH buffer capacity all determined. Saturation prednisolone (unionisable) mesalamine...
The purpose of this study was to investigate the influence gastric emptying patterns, surfactants, and dosage form on supersaturation a poorly soluble weakly basic drug, dipyridamole, using an in vitro model mimicking dynamic environment upper gastrointestinal tract, and, furthermore, evaluate usefulness establishing correlations vivo bioavailability for drugs with solubility/dissolution limited absorption. A simulated stomach duodenum comprising four compartments used assess precipitation...
Abstract Methotrexate is an efficacious immunosuppressant for induction and maintenance of remission in Crohn's disease. The goal this pilot study was to determine whether total or individual methotrexate glutamate levels (MTXGlu n ) red blood cells correlate with disease activity adverse events A cross‐sectional undertaken 12 patients on a stable dose 25 mg weekly (oral subcutaneous). Clinical assessed by the Harvey‐Bradshaw Index (HBI), biologic measured inflammatory markers....
Small tablets for implantation into the subconjunctival space in eye are being developed to inhibit scarring after glaucoma filtration surgery (GFS). There is a need evaluate drug dissolution at molecular level determine how chemical structure of active may correlate with nonsink conditions conjunctival space. We conducted dynamics simulations study process derived from two drugs that can fibrosis GFS, 5-fluorouracil (5-FU) and matrix metalloprotease inhibitor (MMPi), ilomastat. The was...