A5041894017- Drug Solubulity and Delivery Systems
- Drug Transport and Resistance Mechanisms
- Advanced Drug Delivery Systems
- Analytical Methods in Pharmaceuticals
- Pharmaceutical studies and practices
- Gastrointestinal motility and disorders
- Analytical Chemistry and Chromatography
- Protein purification and stability
- Crystallization and Solubility Studies
- Pharmacogenetics and Drug Metabolism
- Gastroesophageal reflux and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Pharmacological Effects of Natural Compounds
- Microfluidic and Capillary Electrophoresis Applications
- Lattice Boltzmann Simulation Studies
- Biosimilars and Bioanalytical Methods
- Microencapsulation and Drying Processes
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microscopic Colitis
- Pharmacology and Obesity Treatment
- Biochemical and Molecular Research
- Statistical Methods in Clinical Trials
- Antifungal resistance and susceptibility
- HIV/AIDS drug development and treatment
AstraZeneca (Sweden)
2015-2024
AstraZeneca (United Kingdom)
2005-2020
Novartis (Switzerland)
2016
University of Manchester
2016
Vårdcentralen Teleborg
2015
St George's Hospital
2010
Swansea University
2010
University of London
2010
Uppsala University
1996-2009
AstraZeneca (Brazil)
2008
The fed human stomach displays regular peristaltic contraction waves that originate in the proximal antrum and propagate to pylorus. High–resolution concurrent manometry magnetic resonance imaging (MRI) studies of suggest a primary function antral wave (ACW) activity unrelated gastric emptying. Detailed evaluation is difficult, however, vivo. Here we analyse role ACW on intragastric fluid motions, pressure, mixing with computer simulation. A two–dimensional model was developed...
The purpose of this study was to increase the understanding in vivo colonic drug absorption humans by summarizing and evaluating all regional human data with focus on interpretation relation intestinal permeability solubility. In addition, usefulness Biopharmaceutics Classification System (BCS) early assessment potential controlled release candidates investigated. Clinical (Cmax, Tmax, AUC) 42 drugs were collected from journal articles, abstracts, internal reports, relative bioavailability...
The purpose of this work was to study the solubility two drugs with different physicochemical properties in luminal fluids obtained from various regions human gastrointestinal (GI) tract and determine most important parameters influencing their solubility. Jejunal were aspirated healthy volunteers via an oral intubation tube. Ileal colonic patients undergoing GI surgery. Stoma also retrieved patients. pH buffer capacity all determined. Saturation prednisolone (unionisable) mesalamine...
Currently there are only a limited number of determinations human Peff in the distal small intestine and none large intestine. This has hindered validation preclinical models with regard to absorption parts intestinal tract, which can be substantial for BCS class II-IV drugs, drugs formulated into modified-release (MR) dosage forms. To meet this demand, three model (atenolol, metoprolol, ketoprofen) were dosed solution intravenously, jejunum, ileum, colon 14 healthy volunteers. The each drug...