A5041751825- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Retinal Diseases and Treatments
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Monoclonal and Polyclonal Antibodies Research
- Nanoparticle-Based Drug Delivery
- Protein purification and stability
- Intraocular Surgery and Lenses
- Glycosylation and Glycoproteins Research
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Ocular Infections and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Healthcare and Venom Research
- Biochemical effects in animals
- Retinopathy of Prematurity Studies
- Plant-based Medicinal Research
- Ophthalmology and Eye Disorders
- Supramolecular Self-Assembly in Materials
- Ocular Disorders and Treatments
- Neuroendocrine regulation and behavior
- Ocular Diseases and Behçet’s Syndrome
- Biological and pharmacological studies of plants
- Cancer Treatment and Pharmacology
University College London
2015-2024
Moorfields Eye Hospital NHS Foundation Trust
2013-2024
National Institute for Health Research
2013-2024
The London College
2012-2022
Moorfields Eye Hospital
2017
NIHR Moorfields Biomedical Research Centre
2013
University of London
2012
Dry eye disease is a common ocular disorder that characterised by tear deficiency or excessive evaporation. Current treatment involves the use of drops; however, therapeutic efficacy limited because poor bioavailability topically applied formulations. In this study, digital light processing (DLP) 3D printing was employed to develop dexamethasone-loaded punctal plugs. Punctal plugs with different drug loadings were fabricated using polyethylene glycol diacrylate (PEGDA) and 400 (PEG 400)...
RNAi induced by double-stranded small interfering RNA (siRNA) molecules has attracted great attention as a naturally occurring approach to silence gene expression with high specificity. The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway is master regulator of cytoskeletal and, thus, represents promising target prevent fibrosis. A major hurdle implementing siRNA therapies the method delivery, and we have, optimized lipid-peptide-siRNA (LPR) nanoparticles...
Inkjet printing has the potential to advance treatment of eye diseases by drugs on demand onto contact lenses for localised delivery and personalised dosing, while near-infrared (NIR) spectroscopy can further be used as a quality control method quantifying drug but yet demonstrated with lenses. In this study, glaucoma therapy drug, timolol maleate, was successfully printed using modified commercial inkjet printer. The drug-loaded ink prepared printer designed match properties ink, whilst...
Abstract Hydrogels can potentially prolong the release of a therapeutic protein, especially to treat blinding conditions. One challenge is ensure that protein and hydrogel are intimately mixed by better entanglement within hydrogel. N ‐isopropylacrylamide (NIPAAM) gels optimized with poly(ethylene glycol) diacrylate (PEDGA) crosslinker in presence either bevacizumab or PEG conjugated ranibizumab (PEG 10 ‐Fab rani ). The profiles hydrogels evaluated using an outflow model eye, which...
Intravitreal injections have become the cornerstone of retinal care and one most commonly performed procedures across all medical specialties. The impact hydrodynamic forces intravitreal solutions when injected into vitreous or substitutes has not been well described. While computational models do exist, they tend to underestimate starting surface area an bolus a drug. Here, we report dispersion profile dye (50 µL) different varying viscosities, tensions, volumetric densities. A novel 3D...
Real-time measurement is important in modern dissolution testing to aid parallel drug characterisation and quality control (QC). The development of a real-time monitoring platform (microfluidic system, novel eye movement with temperature sensors accelerometers concentration probe setup) conjunction an vitro model the human (PK-Eye™) reported. importance surface membrane permeability when modelling PK-Eye™ was determined “pursing model” (a simplified setup hyaloid membrane). Parallel...
New in vitro prototypes (PK-Eye™) were tested with and without eye movement to understand diffusion convection effects on intraocular clearance. Port placement front ((i) ciliary inflow model) behind the model lens ((ii) posterior was used study bevacizumab (1.25 mg/50 µL) dexamethasone (0.1 mg/100 phosphate-buffered saline (PBS, pH 7.4) simulated vitreal fluid (SVF). Dexamethasone studied a (iii) retinal-choroid-sclera (RCS) outflow (with two pathways). Ciliary vs. did not affect half-life...
We previously described FpFs 1̲ (Fab–PEG–Fab) as binding mimetics of IgGs.
Abstract Lipidised analgesic peptide prodrugs self-assemble into nanofibers; with the nanofiber morphology protecting from plasma degradation and improving therapeutic efficacy. Extending this learning, we hypothesised that a self-assembling lipidized arginine vasopressin (AVP) receptor agonist, had not been designed as prodrug, could prove pharmacologically active control urine production. The only approved AVP desmopressin is indicated for treatment of central diabetes insipidus (DI),...