Fiona O’Brien

ORCID: 0000-0001-6633-1441
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About
Contact & Profiles
Research Areas
  • Pharmaceutical studies and practices
  • Child and Adolescent Health
  • Pharmaceutical Practices and Patient Outcomes
  • Pediatric Pain Management Techniques
  • Intravenous Infusion Technology and Safety
  • Patient Safety and Medication Errors
  • RNA Interference and Gene Delivery
  • Neonatal Respiratory Health Research
  • Medication Adherence and Compliance
  • Drug Solubulity and Delivery Systems
  • Ultrasound and Cavitation Phenomena
  • Infant Development and Preterm Care
  • Clinical Nutrition and Gastroenterology
  • Biosensors and Analytical Detection
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Ultrasound and Hyperthermia Applications
  • Healthcare Technology and Patient Monitoring
  • Healthcare Systems and Technology
  • Virus-based gene therapy research
  • Viral Infections and Immunology Research
  • Nursing Education, Practice, and Leadership
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Family and Patient Care in Intensive Care Units
  • Animal Virus Infections Studies
  • Advanced biosensing and bioanalysis techniques

Royal College of Surgeons in Ireland
2012-2024

Royal College of Nursing
1999

Background: Cardiovascular diseases (CVD) account for 36% of deaths in Europe and the United States. Gene therapy can act as a therapeutic modality treatment CVD. The use microRNA mimetics may be advantageous they regulate important

10.3233/thc-130772 article EN Technology and Health Care 2014-02-01

Aims: Delivery of siRNA to the lungs via inhalation offers a unique opportunity develop new treatment paradigm for range respiratory conditions. However, progress has been greatly hindered by safety and delivery issues. This study developed high-throughput method screening novel nanotechnologies pulmonary delivery. Methodology: Following physicochemical analysis, ability PEI–PEG–siRNA nanoparticles facilitate was determined using high-content analysis (HCA) in Calu-3 cells. Results obtained...

10.4155/tde.11.73 article EN Therapeutic Delivery 2011-08-01

Parenteral drug administration in the neonatal intensive care involves complex pharmacotherapy adjusted for patient's weight, fluid allowance, and multi-infusion systems.

10.1093/jpp/rgad108 article EN cc-by Journal of Pharmacy and Pharmacology 2023-12-02

<b>Introduction:</b> Predicting disease progression and mortality in COPD is difficult, however some prediction tools exist (e.g. Gold Standard Framework [GSF]). There evidence that patients with would prefer not to die hospital, the proportion of dying at home our locality lower than national/regional average. This project sought identify inpatients last 12 months life allow more out hospital. <b>Methods:</b> A 'GSF Multi-disciplinary Team' consisting community secondary care staff was...

10.1183/1393003.congress-2017.pa4968 article EN 2017-09-01

<h3>Aim</h3> The aim of this study was to gather the views primary care healthcare professionals (HCPs) on issues faced by parents/carers babies discharged home with medication from neonatal units in UK. This information will be used compare and expand findings data collected HCPs secondary which highlighted challenges that may arise during process. <h3>Method</h3> A stakeholder map created pharmacist support project leads. previous e-survey for amended applicable care.<sup>1</sup> primarily...

10.1136/bmjpo-2024-nppg.8 article EN other-oa 2024-05-01

Sick neonates with haemodynamic instability often require complex medication regimens, which may result in the connection of a catecholamine infusion distally. This increases dead volume system, extending time to delivery. study evaluated effects body weight, and point on delivery rate two medications infused through multi-infusion system at rates suitable for extremely very low birth weight (ELBW VLBW) neonates.

10.1016/j.ejpb.2024.114391 article EN cc-by European Journal of Pharmaceutics and Biopharmaceutics 2024-07-02

Background Human noroviruses are a major cause of epidemic and sporadic gastroenteritis worldwide can chronically infect immunocompromised patients. Efforts to develop effective vaccines antivirals have been hindered by the uncultivable nature extreme genetic diversity human [1]. Previous therapies focused on targeting nucleases structural proteins. The norovirus RNA genome or viral transcripts also constitute an important target inhibit replication norovirus. Finding conserved component...

10.1186/1753-6561-9-s7-a11 article EN cc-by BMC Proceedings 2015-10-27

Introduction Parents of babies who required neonatal care are responsible for managing their medicines after they discharged home. There is wide variation in the information and amount preparation given to parents prior assuming this challenging task. The aim Parent co-Designed Drug Information Guardians Taking Neonates home (PADDINGToN) study was explore parents' experiences babies' post discharge from a unit use develop suitable resources future families. Methods A qualitative...

10.3389/fcomm.2023.1204599 article EN cc-by Frontiers in Communication 2023-10-27

Aim The aim of this project is to work with healthcare professionals (HCPs) and parents/carers co-design resources aimed at improving medication safety reducing parental anxiety for those giving medications neonates home. Method Healthcare Professionals in national international sites parent/caregiver networks were identified using a stakeholder map. An electronic-survey (e-survey) was developed by multi-disciplinary study management group including HCPs expert parents. This circulated...

10.1136/archdischild-2022-nppg.9 article EN Archives of Disease in Childhood 2022-04-20

Abstract Background A study of premature babies, less than 32 weeks gestation, found that the median number medicines per patient at discharge was 2.5 (range 2 to 7), with 28% babies discharged on more 3 (1). Medication administration infants can cause anxiety and concern for parents/carers who worry about making mistakes. systematic review carers all ages has estimated error rate home be between 33% (2) while a 66.3% recorded in medication administered where parents were responsible (3). It...

10.1101/2022.07.10.22277472 preprint EN cc-by medRxiv (Cold Spring Harbor Laboratory) 2022-07-10

The founder of the International Council Nurses is well recognised abroad, but she divided profession in Britain, as Susan McGann and Fiona O'Brien explain this week's Millennium

10.7748/ns.13.40.17.s33 article EN Nursing Standard 1999-06-23
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