A5022617720- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Heavy Metal Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Synthesis and Biological Evaluation
- Trace Elements in Health
- Virtual Reality Applications and Impacts
- Sperm and Testicular Function
- Parasites and Host Interactions
- Reproductive System and Pregnancy
- Oral microbiology and periodontitis research
- Polyomavirus and related diseases
- Air Quality and Health Impacts
- Eosinophilic Disorders and Syndromes
- Immune Response and Inflammation
- Reproductive Health and Technologies
- Carcinogens and Genotoxicity Assessment
- Polyamine Metabolism and Applications
- Toxic Organic Pollutants Impact
- Educational Games and Gamification
- Digital Games and Media
- Virus-based gene therapy research
- Spatial Cognition and Navigation
- Mercury impact and mitigation studies
- Systemic Lupus Erythematosus Research
HES-SO University of Applied Sciences and Arts Western Switzerland
2018-2023
RWTH Aachen University
2011-2021
HAW Hamburg
2020
Jülich Aachen Research Alliance
2017
Michigan State University
1997-2012
Michigan Department of Health and Human Services
2005-2012
Wayne State University
2005-2011
University of Kansas
2011
Cancer Research And Biostatistics
1983-2011
University of Kentucky
2009
Evidence on human semen quality as it relates to exposure various metals, both essential (e.g., zinc, copper) and nonessential cadmium, lead), is inconsistent. Most studies date used small sample sizes were unable account for important covariates.
The effects of gamma interferon (IFN-gamma) on P388D1 cell or mouse resident peritoneal macrophage association (i.e., binding and internalization) with the protozoan Trypanosoma cruzi were studied, as well this lymphokine intracellular parasite killing. Incubation either type a conditioned medium containing IFN-gamma traces interleukin 2 markedly increased capacities cells to associate virulent blood forms T. cruzi, evidenced by significant increases in both proportion parasite-associated...
Phthalates are ubiquitous industrial chemicals that reported to adversely affect human reproductive outcomes. Divergent effects on semen quality have been in a limited number of studies. To assess the possible contribution regional differences phthalate exposure these results, we wished determine if ambient men from Great Lakes region was associated with sperm parameters. Male partners (N=45) subfertile couples presenting Michigan infertility clinic were recruited. Urinary concentrations...
Occupational and experimental animal studies indicate that exposure to high levels of manganese impairs male fertility, but the effects ambient in humans are not known.We measured blood selenium 200 infertility clinic clients a cross-sectional study. Correlations between metals semen variables were determined, adjusting for other risk factors. Outcomes low motility (<50% motile), concentration (<20 million/mL), or morphology (<4% normal). We also investigated dose-response relationships...
We examined in this work whether rTNF inhibits the capacity of Trypanosoma cruzi to multiply within murine macrophages or enhances ability phagocytic host cells destroy internalized parasites. found that would not alter fate trypanosomes over a 48-h incubation period unless latter were also treated with 1 ng/ml bacterial endotoxin (LPS). Treatment plus LPS, but separate treatment either resulted significant decrease number organisms per 100 respect values obtained mock-treated macrophages....
Treatment of either mouse peritoneal macrophages (MPH) or invasive blood forms Trypanosoma cruzi with human plasma fibronectin (FN) significantly enhanced their association (a term to mean surface attachment and parasite internalization) the untreated counterpart in a dose-dependent manner. This effect involved increases percentage MPH that associated parasites number per MPH. By using indirect immunofluorescence, percentages FN-positive found preparations these cells were 26 13%,...
The capacity of blood (trypomastigote) forms Trypanosoma cruzi to infect mouse peritoneal macrophages or rat heart myoblasts in vitro was inhibited by treatment the trypomastigotes with DL-alpha-difluoromethylarginine (F2Me Arg), monofluoromethylagmatine, (E)-alpha-monofluoromethyl-3-4-dehydroarginine--all irreversible inhibitors arginine decarboxylase. Similar results were obtained when F2MeArg-treated parasites incubated myoblasts. inhibitory effects characterized marked reductions both...
The effects of agents that elevate intracellular levels cyclic AMP on the in vitro interaction mouse peritoneal macrophages with virulent bloodstream forms a reticulotropic strain Trypanosoma cruzi were investigated as part our efforts to define requirements for tissue invasion by this human pathogen. At optimal, non-toxic concentrations, both L-isoproterenol and prostaglandin E1, increase activating adenylate cyclase via different mechanisms, reduced uptake T. approximately 30 70%,...
A novel organ- and age-specific pattern of polyomavirus DNA replication in mice is described. Two broadly defined classes response to infection were observed: class I organs (mammary gland, bone, skin) responded with high levels neonate moderate adults; II (kidney, liver, lung) neonates very low adults. Thus, aging affected all organs, organ specificity was superimposed on this age-related decrease. We argue that the likely reflects part activities a multiplicity general or tissue-specific,...
Abstract The effects of leukotriene B4 (LTB4) on mouse peritoneal macrophage (MPH) association with and destruction Trypanosoma cruzi were studied. presence 10(-8) to 10(-6) M LTB4 in co-cultures MPH T. enhanced their (a term meaning surface binding internalization), as evidenced by increases the percentage associating trypanosomes number parasites per 100 MPH. Pretreatment either or increased untreated counterpart, suggesting that enhancement was a composite both cells. effect reversible,...
In patients with diabetes mellitus, increased platelet reactivity predicts cardiac events. Limited evidence suggests that DPP-4 (dipeptidyl peptidase 4) influences platelets via GLP-1 (glucagon-like peptide 1)-dependent effects. Because inhibitors are frequently used in mellitus to improve the GLP-1-regulated glucose metabolism, we characterized role of inhibition and native intact versus DPP-4-cleaved on flow-dependent thrombus formation mouse human blood. Approach Results: An ex vivo whole...
The effects of irreversible inhibition ornithine decarboxylase on the capacity murine macrophages to take up a protozoan organism (Trypanosoma cruzi) or inert particles were investigated. Incubation macrophage cultures with four different inhibitors, namely, DL-alpha-difluoromethylornithine (DFMO, 0.5 20 mM), delta-methyl-acetylenic putrescine (1 5 monofluoromethyldehydroornithine ethyl ester and methyl before addition parasites significantly reduced percentage parasites, indicating that...