A5061266120- Microbial Natural Products and Biosynthesis
- Microbial Metabolism and Applications
- Microbial Metabolic Engineering and Bioproduction
- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Biochemical and Structural Characterization
- Probiotics and Fermented Foods
- Diabetes Treatment and Management
German Center for Infection Research
2023-2024
University of Bonn
2023-2024
University Hospital Bonn
2023-2024
Abstract Many bacteria produce antimicrobial compounds such as lantibiotics to gain advantage in the competitive natural environments of microbiomes. Epilancins constitute an until now underexplored family with unknown ecological role and unresolved mode action. We discovered production epilancin nasal isolate Staphylococcus epidermidis A37. Using bioinformatic tools, we found that epilancins are frequently encoded within staphylococcal genomes, highlighting their relevance. demonstrate A37...
In patients with diabetes mellitus, increased platelet reactivity predicts cardiac events. Limited evidence suggests that DPP-4 (dipeptidyl peptidase 4) influences platelets via GLP-1 (glucagon-like peptide 1)-dependent effects. Because inhibitors are frequently used in mellitus to improve the GLP-1-regulated glucose metabolism, we characterized role of inhibition and native intact versus DPP-4-cleaved on flow-dependent thrombus formation mouse human blood. Approach Results: An ex vivo whole...
ABSTRACT Staphylococcus epidermidis , a commensal bacterium inhabiting collagen-rich areas, like human skin, has gained significance due to its probiotic potential in the nasal microbiome and as leading cause of nosocomial infections. While infrequently severe illnesses, S. exerts significant influence, particularly close association with implant-related infections role classic opportunistic biofilm former. Understanding nature is crucial for developing novel therapeutic strategies,...