A5101851068- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Acute Kidney Injury Research
- Adolescent and Pediatric Healthcare
- Chronic Kidney Disease and Diabetes
- Antibiotics Pharmacokinetics and Efficacy
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Pharmaceutical studies and practices
- Atherosclerosis and Cardiovascular Diseases
- Urticaria and Related Conditions
- Platelet Disorders and Treatments
- Childhood Cancer Survivors' Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Pharmacological Effects and Toxicity Studies
- Biomedical Research and Pathophysiology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Poisoning and overdose treatments
- Potassium and Related Disorders
- Liver Diseases and Immunity
- Health Literacy and Information Accessibility
- Pediatric Urology and Nephrology Studies
University of Liverpool
2015-2025
Alder Hey Children's NHS Foundation Trust
2016-2025
University College London
2024-2025
Roland Hill (United Kingdom)
2024-2025
Great Ormond Street Hospital
2025
Kidney Care UK
2025
Great Ormond Street Hospital for Children NHS Foundation Trust
2023-2024
Alder Hey Children's Hospital
2016-2024
Cardiff University
2024
The Royal Free Hospital
2024
Abstract Objectives The association of B cell targeted therapies with development hypogammaglobulinaemia and infection is increasingly recognized. Our aim was to develop consensus recommendations for immunoglobulin replacement therapy management following in autoimmune rheumatic diseases. Methods A modified Delphi exercise involved a 17-member Taskforce committee, consisting immunologists, rheumatologists, nephrologists, haematologists, gastroenterologist, an immunology specialist nurse...
Abstract Background There is paucity of information on rituximab-associated hypogammaglobulinemia (HGG) and its potential infectious consequences in children treated for idiopathic nephrotic syndrome (INS). Methods A survey was distributed by the European Society Pediatric Nephrology to members. It addressed screening management practices pediatric nephrology units recognizing treating RTX-associated HGG morbidity mortality. Eighty-four centers which had an overall 1328 INS with RTX...
Abstract Background Information leaflets in research studies should be age-appropriate to understood, however the formal readability of children’s participant information (PILs) for has not been assessed. Methods A single-centre cross-sectional study assessing paediatric PILs. Six tests were applied (Gunning Fog Index (GFI), Simple Measure Gobbledygook (SMOG), Flesch Kincaid Grade Level (FKGL), Coleman–Liau (CLI), Automated Readability (ARI) and Reading Ease score (FRE). Results compared...
Oni, Louise; McKenzie, Jennifer; Seide, Svenja; Smoyer, William E.; Trachtman, Howard Author Information
Immunoglobulin A (IgA) vasculitis (IgAV, also known as Henoch-Schoenlein purpura, HSP) is a small vessel vasculitis, most commonly presenting in childhood. In most, it has straightforward, self-limiting disease course, however some children may develop kidney involvement (IgAV-N) which occurs 4-12 weeks following onset and remains the biggest contributor to long-term morbidity. Therefore, undergo six-month period of monitoring identify nephritis via surrogate markers including urinalysis...
Poor literacy can impact achieving optimal health outcomes. The aim of this project was to assess the readability parent information leaflets (PILs).A single-centre study using paediatric PILs. Five tests were applied (Gunning Fog Index (GFI), Simple Measure Gobbledygook (SMOG), Flesch Kincaid Grade Level (FKGL), Coleman-Liau (CLI) and Automated Readability (ARI)). Results compared standards by subtype.A total 109 PILs obtained; mean (±SD) number characters 14,365 (±12,055), words 3066...
ABSTRACT Background Immunoglobulin A vasculitis with nephritis (IgAVN) is the most common in children. Due to a lack of evidence, treatment recommendations are based on expert opinion, resulting variation. The aim this study was describe clinical presentation, and outcome an extremely large cohort children biopsy-proven IgAVN order identify prognostic risk factors signals efficacy. Methods Retrospective data were collected 1148 between 2005 2019 from 41 international paediatric nephrology...
Abstract Objectives IgA vasculitis (IgAV) in adults has been relatively under-investigated. Since outcomes are worse other forms of with increasing age, we investigated the IgAV comparing younger (18–34), middle-aged (35–64) and elderly patients (≥64 years) focusing on kidney outcomes. Methods We identified renal biopsy-confirmed nephritis collected data regarding clinical features progression to end stage disease (ESKD). The relationship between patient factors ESKD was analysed by...
The gold standard for the classification of lupus nephritis is renal histology but reporting variation exists. aim this study was to assess inter-observer variability 2003 International Society Nephrology/Royal Pathology (ISN/RPS) histological criteria in children. Histopathologists from a reference centre and three tertiary paediatric centres independently reviewed digitalized slides 55 children with nephritis. Histological ISN/RPS Class assigned features scored; nephritis-activity [scored...