A5059632971- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Complement system in diseases
- Pediatric Urology and Nephrology Studies
- COVID-19 Clinical Research Studies
- Urinary Tract Infections Management
- Nephrotoxicity and Medicinal Plants
- Renal Transplantation Outcomes and Treatments
- Acute Kidney Injury Research
- Renal and Vascular Pathologies
- Inflammasome and immune disorders
- Urological Disorders and Treatments
- Muscle and Compartmental Disorders
- Biomedical Research and Pathophysiology
- Microscopic Colitis
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Celiac Disease Research and Management
- Cerebral Venous Sinus Thrombosis
- Blood Pressure and Hypertension Studies
- Organ Transplantation Techniques and Outcomes
- Renal and related cancers
- Pregnancy and Medication Impact
- Chronic Kidney Disease and Diabetes
- Sepsis Diagnosis and Treatment
Hacettepe University
2011-2025
Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
2020-2022
Sağlık Bilimleri Üniversitesi
2022
Ankara University
2014-2021
Ministry of Health
2018-2021
Zübeyde Hanim Maternity Hospital
2020
Departamento de Epidemiología
2019
Pediatric Nephrology of Alabama
2016-2019
Gaziantep Children's Hospital
2015
Steroid-resistant nephrotic syndrome (SRNS) is a severe kidney disorder linked to over 60 genes, including NUP85, which plays key role in nuclear pore function and glomerulogenesis. We identified novel homozygous NUP85 variant (NM_024844.5: c.1379G > A, p.Arg460Gln) pediatric SRNS patient who also presented with cleft lip-palate mild intellectual disability, marking the first reported association of these phenotypes variant. Molecular dynamics simulations revealed that destabilizes protein's...
ABSTRACT Background Immunoglobulin A vasculitis with nephritis (IgAVN) is the most common in children. Due to a lack of evidence, treatment recommendations are based on expert opinion, resulting variation. The aim this study was describe clinical presentation, and outcome an extremely large cohort children biopsy-proven IgAVN order identify prognostic risk factors signals efficacy. Methods Retrospective data were collected 1148 between 2005 2019 from 41 international paediatric nephrology...
There are many controversies regarding the best approach for evaluating children after their first febrile urinary tract infection (UTI). The aim of this study was to define clinical, laboratory, and radiological features patients with UTI investigate factors that might predict presence vesicoureteral reflux (VUR) renal scarring.The files who were followed due between 2008 2013 retrospectively reviewed (n = 300). Patients divided into groups based on age, resistance state microorganisms,...
This study shares data on 417 patients with genetic disorders of skeleton including 10 fetal autopsies encountered in a 5-year period at tertiary university hospital Ankara, Turkey. We included osteochondrodysplasias, excluding overgrowth syndromes, dysostoses, and craniofacial syndromes. When grouped according to the "International Skeletal Dysplasia Society 2010 classification" most frequent group is "FGFR3 group" (achondroplasia). "Decreased bone density takes second place, consistent...
Knowledge on normal progress and treatment of Henoch-Schönlein purpura nephritis (HSPN) is limited. This study reviews outcome, clinical, pathological, therapeutic factors affecting the prognosis HSPN patients.Forty-nine children with biopsy-confirmed diagnosed between September 2008 2018 were included. Demographics, clinical laboratory data, treatment, outcome recorded at time biopsy, 3, 6, 12, 24 months last visit. Clinical was graded according to Meadow's criteria.The median age biopsy...
This study was conducted to evaluate the changes in BP and LVH after transplantation effect of LVH. Forty-three pediatric renal transplant patients, with a mean age 16.99 ± 3.88 years, were enrolled this study. Twenty-three (53.5%) patients male. Medical records for pretransplantation period (closest time transplantation) post-transplantation (9-12 months reviewed. All had measurements echocardiographic evaluation pre- period. Hypertension defined as an average systolic and/or diastolic that...
Renovascular hypertension in most cases requires endovascular treatment and/or surgery. This is technically much more difficult small children and there very limited published knowledge this age group. We here present outcome of young with renovascular at our institution. Children below 2 years age, between January 1998 March 2020 were retrospectively reviewed. Demographics modalities noted. Primary was blood pressure within a week after the procedures last available visit. Sixty-six...
Increased ultrasonography (US) use has been correlated with an increased incidence of pediatric renal cysts. For simple and stage II cysts, the malignancy risk is low in adulthood, no follow up recommended; but there consensus on childhood management. Given that cysts may be manifestations hereditary cystic diseases, a different approach should taken for these patients. Herein we present clinical characteristics follow-up data patients cysts.This cross-sectional study involved 57 children...
Primary hyperoxaluria type 1 is a rare autosomal-recessive disease caused by the deficient activity of liver specific enzyme alanine-glyoxylate aminotransferase. Increased endogenous oxalate production induces severe hyperoxaluria, recurrent urolithiasis, progressive nephrocalcinosis and renal failure. Here we report 6 month old boy who presented with vomiting decreased urine volume. He was diagnosed chronic kidney failure at 4 months age peritoneal dialysis introduced local hospital. His...
Abstract Background Increased antimicrobial resistance is a problem in managing urinary tract infections (UTI). With this study we assessed the patterns of isolates children with UTI between January 2017 and 2018. Methods A retrospective cohort was conducted. Among 5,443 isolates, total 776 episodes 698 patients were included. Patients' gender, age, voiding dysfunction, history, prophylaxis status, presence vesicoureteral reflux noted. Patients divided into three age groups: group 1 for ages...
Introduction.The aim of the study was to assess clinical features and outcome parameters children with vesicoureteral reflux (VUR) based on gender VUR grade.Population methods.Patients who were seen during routine follow-up visits at Ankara University Children's Hospital between January 2014-January 2015 included in this retrospective study.Patient demographics, course, laboratory investigations, imaging noted.Results.Two hundred twenty patients recruited.Mean age time diagnosis 3,17 ± 3,08...
Abstract Proteinuria has been shown to be an important and potentially treatable risk factor for graft loss. The aim of this study was evaluate prevalence, etiology, outcome proteinuria during the follow‐up children with renal transplantation. We retrospectively reviewed files transplanted between 2006 2016 in our center. All patients were interpreted respect demographic data clinical laboratory features including information about proteinuria. Chi‐square test Mann‐Whitney U used analysis....
Background: C3 glomerulopathy (C3G) is an uncommon disease characterized by the deposition of complement factors in glomeruli due to overactivation and dysregulation alternative pathway complement.Objectives: This study aimed describe clinicopathological features, laboratory testing, clinical course, treatment, outcomes pediatric patients with C3G.Patients Methods: We reviewed retrospectively kidney biopsy reports, features 18 at our hospital from 2007 2019.Results: There were cases,...
<b><i>Objectives:</i></b> Familial Mediterranean fever (FMF) is a monogenic auto-inflammatory disease which might rarely cause glomerulopathy in patients. The aim of this study was to determine the clinical, demographic, and genetic characteristics type glomerular lesions pediatric FMF patients who underwent kidney biopsy. <b><i>Methods:</i></b> data 30 with biopsy-proven were retrospectively reviewed. Patients grouped into 2 categories as...
Abstract Background Acute tubulointerstitial nephritis (ATIN) is a rare cause of acute kidney injury in children that can lead to chronic disease. The aim this study was describe the presenting features, etiology, and clinical characteristics childhood ATIN, evaluate treatment modalities renal outcomes. Methods included 38 patients who had been diagnosed with were younger than 18 years old, admitted for at least 6 months follow up. Results median age diagnosis 13.1 (range 1.2–16.6 years)....