A5101402417- Geophysical Methods and Applications
- Ultrasonics and Acoustic Wave Propagation
- Dialysis and Renal Disease Management
- Spaceflight effects on biology
- Seismic Waves and Analysis
- Renal Diseases and Glomerulopathies
- Microfluidic and Capillary Electrophoresis Applications
- Space Exploration and Technology
- Planetary Science and Exploration
- History of Medicine Studies
- Adolescent and Pediatric Healthcare
- Molecular Biology Techniques and Applications
- Neonatal Health and Biochemistry
- History of Science and Medicine
- Microfluidic and Bio-sensing Technologies
- Genomics and Phylogenetic Studies
- Near-Field Optical Microscopy
- RNA and protein synthesis mechanisms
- Ophthalmology and Visual Health Research
- Pregnancy and Medication Impact
- Platelet Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Space Science and Extraterrestrial Life
- Magnesium in Health and Disease
DNA Medicine Institute (United States)
2004-2024
Duchess of Kent Children's Hospital
2024
Chinese University of Hong Kong
2024
Starship Children's Health
2024
RMIT University
2014-2016
RMIT Europe
2014
ID Genomics (United States)
2004
Zhongshan Ophthalmic Center, Sun Yat-sen University
1988
Sun Yat-sen University
1988
Chinese Academy of Medical Sciences & Peking Union Medical College
1982
We have developed a rapid molecular mapping technology—Direct Linear Analysis (DLA)—on the basis of analysis individual DNA molecules bound with sequence-specific fluorescent tags. The apparatus includes microfluidic device for stretching in elongational flow that is coupled to multicolor detection system capable single-fluorophore sensitivity. Double-stranded were tagged at motif sites bisPNA (Peptide Nucleic Acid) then stretched and driven stream past confocal fluorescence detectors. DLA...
IntroductionGram-negative peritonitis (GNP) is associated with significant morbidity in children receiving long-term peritoneal dialysis (PD) and current treatment recommendations are based on limited data. Methods: Analysis of 379 GNP episodes 308 (median age 6.9 years, IQR 3.0-13.6) from 45 centers 28 countries reported to the International Pediatric Peritoneal Dialysis Network (IPPN) registry between 2011–2023. Results: Overall, 74% responded well empiric therapy full functional recovery...
We have fabricated using electron beam nanolithography a fixed slit near-field optical scanning device which uses fluorimetry to achieve 200 nm spatial resolution of objects moving over the slits. explore basic physics operating narrow slits in waveguide cutoff mode and present data from passage extended double-stranded DNA molecules passing as first example how this can be used do ultrahigh mapping long polymers.
ABSTRACT Background Immunoglobulin A vasculitis with nephritis (IgAVN) is the most common in children. Due to a lack of evidence, treatment recommendations are based on expert opinion, resulting variation. The aim this study was describe clinical presentation, and outcome an extremely large cohort children biopsy-proven IgAVN order identify prognostic risk factors signals efficacy. Methods Retrospective data were collected 1148 between 2005 2019 from 41 international paediatric nephrology...
It is undeniable that the increasing costs in healthcare are a concern. Although technological advancements have been made systems, return on investment by governments and payers has poor. The current model of care unsustainable due for an upgrade. In developed nations, law diminishing returns noted population health standards, whilst developing world, westernized chronic illnesses, such as diabetes cardiovascular disease become emerging problems. reasons these trends complex, multifactorial...
Over the last 5 decades, laboratory medicine has witnessed a remarkable wave of innovations that transformed field from peripheral to central player in healthcare delivery. These advances enabled introduction and performance new tests on large scale, some decentralized setting, an accurate precise manner, thus leading better diagnosis, more prediction disease prognosis, improved patient management. This evolution was result both sustaining disruptive innovation, latter being concept,...
Real-time lab analysis is needed to support clinical decision making and research on human missions the Moon Mars. Powerful laboratory instruments, such as flow cytometers, are generally too cumbersome for spaceflight. Here, we show that scant test samples can be measured in microgravity, by a trained astronaut, using miniature cytometry-based analyzer, rHEALTH ONE, modified specifically The base device addresses critical spaceflight requirements including minimal resource utilization...
Until recently, astronaut blood samples were collected in-flight, transported to earth on the Space Shuttle, and analyzed in terrestrial laboratories. If humans are travel beyond low Earth orbit, a transition towards space-ready, point-of-care (POC) testing is required. Such needs be comprehensive, easy perform reduced-gravity environment, unaffected by stresses of launch spaceflight. Countless POC devices have been developed mimic laboratory scale counterparts, but most narrow applications...
Reflections of guided waves by features in structures complex geometry, such as panels with stiffeners, present a significant difficulty for locating and quantifying damage. In specific cases where the damage is far away from reflecting boundary or substructure, time-gating techniques may be applied to remove reflections. this work we examine effectiveness multi-frequency method address multi-path reflections using time-reversal diffraction tomography techniques. Imaging results show...
Background Point-of-care (PoC) testing of platelet count (PLT) provides real-time data for rapid decision making. The goal this study is to evaluate the accuracy and precision counting using a new microvolume (8 μL), absolute counting, 1.5 kg cytometry-based blood analyzer, rHEALTH ONE (rHEALTH) in comparison with International Society Laboratory Hematology (ISLH) method, which uses cytometer an impedance analyzer. Methods Inclusion eligibility were healthy adults (M/F) ages 18–80 donation...
Lamb waves are guided that propagate in plate-like structures. These well suited for wide-area inspection, such as aircraft wing skins, because of their relatively slow geometrical decay with propagation distance. Recently, a computationally efficient algorithm situ imaging was derived based on the multi-static data matrix. Here, previous work single circular inhomogeneity is extended to case structural damage spread over two distinct sites. Detailed results presented rank and bandwidth...
Until recently, astronaut blood samples were collected in-flight, transported to earth on the Space Shuttle, and analyzed in terrestrial laboratories. If humans are travel beyond low Earth orbit, a transition towards space-ready, point-of-care (POC) testing is required. Such needs be comprehensive, easy perform reduced-gravity environment, unaffected by stresses of launch spaceflight. Countless POC devices have been developed mimic laboratory scale counterparts, but most narrow applications...
A nanofluidic device for the routine stretching of single DNA molecules was hypothesised and tested. The consists an entrance channel leading to a post-field preceding elongational flow field. facilitates each molecule's coil-to-stretch transition, counteracts its entropic recoil, presents stream moving stretched detailed single-molecule time-of-flight measurements. physics explored in where there juxtaposition hexagonal upright post arrays with lithographically defined fields.