A5044094011- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Ethics in Clinical Research
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Food Allergy and Anaphylaxis Research
- Systemic Lupus Erythematosus Research
- Pharmaceutical Practices and Patient Outcomes
- Otitis Media and Relapsing Polychondritis
- Urticaria and Related Conditions
- Child and Adolescent Health
- Pharmaceutical studies and practices
- Single-cell and spatial transcriptomics
- Biosimilars and Bioanalytical Methods
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
University of Liverpool
2022-2025
Immunoglobulin A (IgA) vasculitis (IgAV, also known as Henoch-Schoenlein purpura, HSP) is a small vessel vasculitis, most commonly presenting in childhood. In most, it has straightforward, self-limiting disease course, however some children may develop kidney involvement (IgAV-N) which occurs 4-12 weeks following onset and remains the biggest contributor to long-term morbidity. Therefore, undergo six-month period of monitoring identify nephritis via surrogate markers including urinalysis...
IgA vasculitis (IgAV) is a small vessel that more common in childhood. Very limited evidence exists on patients who experience an atypical disease course. The aim of this study was to describe cohort children diagnosed with recurrent or persisting IgAV identify any themes associated their course and areas unmet needs.A single centre retrospective at Alder Hey Children's Hospital (Liverpool, UK). Clinical data, including features presentation during follow up, potential triggers, abnormal...
Objective IgA vasculitis (IgAV) is the most frequently experienced subtype of seen in children. Most children fully recover, however, complications including chronic kidney disease are recognised. The aim this project was to use a best available evidence, group agreement, based approach develop national recommendations for initial management IgAV and its associated complications. Methods A representative multiprofessional guideline development (GDG), consisting 28 members, formed met...
Abstract Background Children with immunoglobulin A vasculitis (IgAV Henoch-Schönlein purpura) frequently encounter nephritis (IgAV-N) 1–2% risk of kidney failure. The pathophysiology IgAV-N is not fully understood speculation that complement may contribute. aim this study was to identify whether urinary proteins are increased in children IgAV-N. Methods cross-sectional prospective cohort IgAV were recruited together controls including healthy and systemic lupus erythematosus (SLE). Patients...
Chronic kidney disease is a recognised complication of immunoglobulin A vasculitis, (IgAV; formerly Henoch-Schonlein purpura-HSP). The pathophysiology IgAV and why some patients develop significant renal involvement remains largely unknown. Identifying urinary inflammatory markers could direct targets for earlier intervention. aim this cross-sectional exploratory study was to perform large protein array analysis identify provide insight into the mechanisms inflammation in children with...
IgA vasculitis (IgAV) is the most common form of paediatric vasculitis, with up to 50% patients experiencing kidney inflammation. Much remains unknown about IgAV, but it believed arise due galactose-deficient IgA1 promoting an auto-inflammatory response. This study assesses whether urinary can be detected in children IgAV allow further evaluation and has any relationship nephritis. Urinary serum concentrations were measured using commercially available ELISA kits. Patients grouped into...
IgA vasculitis (IgAV) is the most common form of childhood vasculitis. Nephritis (IgAVN) occurs in 50% patients and 1-2% progress to chronic kidney disease stage 5. The pathophysiology nephritis remains largely unknown, but recent evidence suggests that complement system may be involved. aim this cross-sectional study was explore whether there alternative and/or lectin pathway activation children with IgAVN. Children IgAV were recruited grouped according proteinuria: IgAVN or without...
Opinion statement Paediatric rheumatological diseases are a group of multi-systemic inflammatory affecting children and young people. The kidneys constitute target organ during the acute presentation life course several conditions including childhood systemic lupus erythematosus (cSLE), IgA vasculitis ANCA-associated vasculitis. Unlike adults with rheumatic diseases, who may have prior concomitant kidney disease, more likely to an acute, potentially reversible process that typically requires...
IgA Vasculitis (IgAV) is the most common form of vasculitis in children, and 1–2% patients develop chronic kidney disease. In other forms glomerulonephritis, there strong evidence to support role renin-angiotensin-aldosterone system (RAAS); however, data are lacking IgAV nephritis. This study evaluated urinary RAAS components children with vasculitis, both nephritis (IgAVN) without (IgAVwoN). Urinary concentrations renin, angiotensinogen aldosterone were quantified using ELISAs. total, 40...
Background The use of at home microsampling devices, such as dried aliquots blood and urine, for scientific research has expanded in recent years. These devices collect small volumes biofluids which air dry can be posted to central laboratories. In general, they are cheaper more convenient, saving patients travel time freeing up staff. adult populations, this sampling method is well perceived, with >90% samples being adequate size quality research. However, little literature on paediatric...
Abstract Background IgA vasculitis (IgAV) is a small vessel that more common in childhood. Very limited evidence exists on patients who experience an atypical disease course. The aim of this study was to describe cohort children diagnosed with recurrent or persisting IgAV identify any themes associated their course and areas unmet needs. Methods A single centre retrospective at Alder Hey Children’s Hospital (Liverpool, UK). Clinical data, including features presentation during follow up,...
<h3>Aims</h3> Chronic kidney disease is a recognised complication of Immunoglobulin A Vasculitis (IgAV, previously Henoch Schonlein Purpura, HSP). The exact pathophysiology this and the reasons why some patients develop significant renal involvement remain largely unknown (1). Identifying urinary inflammatory markers could aid identification targets for earlier diagnosis and/or treatment. aim exploratory study was to perform large protein array analysis identify key inflammation in children...
<h3>Aims</h3> Up to 30% of children with IgA vasculitis (IgAV; previously Henoch-Schönlein Purpura) will experience at least one relapse the disease, sometimes months or even years after initial presentation. Those cases pose a diagnostic and therapeutic challenge clinicians due lack consensus on classification treatment recurrent persisting IgAV.<sup>1</sup> The aim this retrospective case series was describe cohort diagnosed either IgAV. <h3>Methods</h3> Children diagnosis IgAV followed-up...