A5080639702- Flowering Plant Growth and Cultivation
- Plant Physiology and Cultivation Studies
- Renal Diseases and Glomerulopathies
- Growth and nutrition in plants
- Vasculitis and related conditions
- Clay minerals and soil interactions
- Galectins and Cancer Biology
- Complement system in diseases
- Systemic Lupus Erythematosus Research
- Agriculture, Soil, Plant Science
- Cell Adhesion Molecules Research
- Ecology and Conservation Studies
- Signaling Pathways in Disease
- Banana Cultivation and Research
- Seedling growth and survival studies
- Forest ecology and management
- Soil and Water Nutrient Dynamics
- Composting and Vermicomposting Techniques
- Syphilis Diagnosis and Treatment
- Plant Water Relations and Carbon Dynamics
- Heavy Metals in Plants
- Plant nutrient uptake and metabolism
- Rangeland and Wildlife Management
- Phosphorus and nutrient management
- Glycosylation and Glycoproteins Research
Virginia Tech
1980-2023
University of Liverpool
2006-2022
William Harvey Research Institute
2014-2021
Queen Mary University of London
2014-2021
University of Manchester
2021
Stanford University
1996-2017
Liverpool Women's Hospital
2016
University of Illinois Urbana-Champaign
1983
The Ohio State University
1983
Ohio Department of Agriculture
1983
CcrM, an adenine DNA methyltransferase, is essential for viability in Caulobacter crescentus. The CcrM protein present only the predivisional stage of cell cycle, resulting cell-cycle-dependent variation methylation state chromosome. availability controlled two ways: (1) ccrM gene transcribed predivisional. cell, and (2) rapidly degraded prior to division. We demonstrate here that important target Lon protease pathway C. In a lon null mutant, transcription still temporally regulated, but...
Photosynthetic and respiration rates were measured in the field on plants of many species growing between elevations 4,500 12,700 ft White Mts. California. No relation was found photosynthetic rate elevation at which growing. However, representing both tree shrub high generally had greater lower photosynthesis/respiration ratios same temperature than did members low species. Gas exchange diverse elevational origin grown from seed a uniform ernvironment series temperatures CO2 levels. Certain...
Fetal growth restriction (FGR) and stillbirth are associated with placental dysfunction inflammation hypoxia, oxidative nitrative stress implicated in damage. Damage-associated molecular patterns (DAMPs) elevated pregnancies at increased risk of FGR increase pro-inflammatory cytokines. We hypothesised that insults lead to release DAMPs, promoting inflammation. Placental tissue from uncomplicated was exposed vitro or stress. Tissue production DAMPs cytokines determined. Oxidative hypoxia...
An analysis was made of the prominent vegetation features as they relate to elevation and substrate in White Mts. California. This study confined elevations between 9,500 13,500 ft., encompassing subalpine alpine zones. Three geological sub- strates were considered; granite, sandstone, dolomite. The environ- mental gradient quantified with measurements air soil temperatures, precipitation moisture tension. elevational change structure found be controlled a large extent by type. Trees occur...
Abstract The pour-through (PT) method of nutrient extraction, which involves pouring water on the container media surface and collecting extract (leachate), was compared to saturated soil (SSE) for a 100% pine bark medium at capacity (102% gravimetric moisture). SSE PT correlation coefficients, respectively, were 0.99 0.94 N, 0.97 P, 0.93 K, 0.98 pH. As moisture levels increased from 50 102%, soluble salt 1.5 1.6 times, while nitrate 1.7 respectively. volume applied varied 40 100 ml did not...
Neutrophil trafficking is a key component of the inflammatory response. Here, we have investigated role immunomodulatory lectin Galectin-9 (Gal-9) on neutrophil recruitment. Our data indicate that Gal-9 upregulated in inflamed vasculature RA synovial biopsies and report release into extracellular environment following endothelial cell activation. siRNA knockdown resulted reduced adhesion recruitment was significantly knockout mice model zymosan-induced peritonitis. We also provide evidence...
Lupus nephritis (LN) affects up to 80% of juvenile onset systemic lupus erythematosus patients, leading end stage renal failure requiring dialysis or transplantation in 10–15%. Podocytes are specialized epithelial cells the glomerulus known be a key site damage glomerular diseases. However, their roles LN have yet fully identified. This project aims identify structural and functional podocytes an vitro model LN. Conditionally immortalized were treated with proinflammatory cytokines (IL-1β,...
Abstract Juvenile-onset lupus nephritis (LN) affects up to 80% of juvenile-onset systemic erythematosus patients (JSLE). As the exact role human renal glomerular endothelial cells (GEnCs) in LN has not been fully elucidated, aim this study was investigate their involvement LN. Conditionally immortalised GEnCs (ciGEnCs) were treated with pro-inflammatory cytokines known be involved pathogenesis and also LPS. Secretion surface expression proteins quantified via ELISA flow cytometry. NF-κΒ...
Lupus nephritis (LN) affects up to 80% of juvenile-onset systemic lupus erythematosus patients. Mesangial cells (MCs) comprise a third the glomerular and are key contributors fibrotic changes within kidney. This project aims identify roles MCs in an vitro model LN.Conditionally immortalised were treated with pro-inflammatory cytokines or patient sera LN assessed for their inflammation fibrosis.MCs shown produce response inflammatory environment LN. Further expressed increased levels mRNA...
Abstract Galectin-3 has been associated with a plethora of proinflammatory functions because its ability, among others, to promote neutrophil activation and the reduction in recruitment models infection Gal-3-null mice. Conversely, it also linked resolution inflammation through actions as an opsonin ability efferocytosis apoptotic neutrophils. Using self-resolving model peritonitis, we have addressed modulation role Gal-3 acute inflammation. We shown that expression is increased neutrophils...
Galectin-1 (Gal-1) exerts immune-regulatory and anti-inflammatory actions in animal models of acute chronic inflammation. Its release into the extracellular milieu often correlates with peak inflammation suggesting that it may serve a pro-resolving function. Gal-1 is reported to inhibit neutrophil recruitment induce surface exposure phosphatidylserine, an 'eat me' signal on neutrophils, yet its role resolution remains be fully elucidated. We hypothesised properties are mediated through...
Summary Bioassays with tomato and lettuce seeds three plant experiments marigold ( Tagetes erecta L.) 'Inca Gold' were conducted in the laboratory greenhouse, respectively, order to investigate possibilities of determining mitigating effects phytotoxins pine tree substrate (PTS). PTS is produced by grinding loblolly Pinus taeda logs, using as horticultural growing substrate. extracts obtained cold hot water reduced germination rate radicle growth lettuce. After washing, an improvement was...
Abstract Rooted linears of Ilex crenata Thunb. ‘Helleri’ and ‘Rotundifolia’ were grown in polyvinyl chloride pipe sections from which longitudinal could be removed for root observations. Plants fertilized at either 150 or 300 ppm N with a 20N–8.7P–16.5K soluble fertilizer. Rate shoot growth was determined through 2-3 flushes by taking weekly measurements shoots roots. Root both cultivars episodic nature active usually preceding flush 1 to 2 weeks. This pattern observed fertility levels.
The environment and phytosociological characteristics of the pinyon woodland zone White Mountains California are described contrasted with those other southwestern representatives this vegetation type. Mts. is floristically allied to Nevada parts Utah. Mt. unique in high upper elevation limit it attains (9,500 ft) low amount average annual precipitation receives (8 12 inches). Apparent fluctuations population structure pine through time related grazing history catastrophic climatic events.
Abstract Pine bark was shown to adsorb 1.5 mg of N/g when NH 4 solutions were leached through the bark. Increasing pH increased adsorbed . At 3.3, only particles a fertilizer solution containing , Ca, K, and Mg applied. However, adsorption other cations as from 3.8 5.8. These data indicate that 2 types sites exist for pine One site is effective at lower pH; active increases. Daily application 2.5 cm water 50 ppm required 20 days equilibration occur so satisfy all binding sites. Thus,...