A5036807715- Immunodeficiency and Autoimmune Disorders
- Inhalation and Respiratory Drug Delivery
- COVID-19 Clinical Research Studies
- Occupational exposure and asthma
- Respiratory Support and Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Occupational Health and Safety Research
- Fungal Infections and Studies
- Chronic Lymphocytic Leukemia Research
- Drug-Induced Adverse Reactions
- Nail Diseases and Treatments
- Antifungal resistance and susceptibility
- Asthma and respiratory diseases
- Blood disorders and treatments
- COVID-19 and healthcare impacts
- Cystic Fibrosis Research Advances
- Platelet Disorders and Treatments
- Infective Endocarditis Diagnosis and Management
- Occupational and environmental lung diseases
- Streptococcal Infections and Treatments
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Blood groups and transfusion
- COVID-19 epidemiological studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
North Bristol NHS Trust
2014-2023
Dignitas International
2016-2019
National Health Service
2019
The Royal Free Hospital
2019
University College London
2019
Royal Free London NHS Foundation Trust
2019
University Teaching Hospital
2018
Toi Ohomai Institute of Technology
2017
St George's, University of London
2017
Southmead Hospital
2012-2015
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and immunogenicity a viral vectored vaccine that expresses spike protein SARS-CoV-2.
Cryptococcal meningitis accounts for more than 100,000 human immunodeficiency virus (HIV)-related deaths per year. We tested two treatment strategies that could be sustainable in Africa the standard of 2 weeks amphotericin B plus flucytosine and effective widely used fluconazole monotherapy.We randomly assigned HIV-infected adults with cryptococcal to receive an oral regimen (fluconazole [1200 mg day] [100 kilogram body weight weeks), 1 week (1 day), or day). Each patient was also as a...
BACKGROUND--Glutaraldehyde is the best disinfectant for fibreoptic endoscopes. It also used in processing of x ray films. A number studies have reported eye, nose, and respiratory symptoms exposed workers. Three individual case reports occupational asthma endoscopy workers a radiographer been published. We describe further seven cases due to glutaraldehyde departments, together with exposure levels measured during challenge tests 19 departments region. METHODS--Eight were referred...
Abstract In March 2020, the United Kingdom Primary Immunodeficiency Network (UKPIN) established a registry of cases to collate outcomes individuals with PID and SID following SARS-CoV-2 infection treatment. A total 310 in or have now been reported UK. The overall mortality within cohort was 17.7% (n = 55/310). Individuals CVID demonstrated an fatality rate (IFR) 18.3% 17/93), receiving IgRT had IFR 16.3% 26/159) SID, 27.2% 25/92). higher inpatient died at younger age than general population....
Exposure to chromium during electroplating is a recognised though poorly characterised cause of occupational asthma. The first series such patients referred specialist lung disease clinic reported.The diagnosis asthma was made from history with rest day improvement and confirmed by specific bronchial provocation testing potassium dichromate nickel chloride.Seven workers had been exposed chrome fumes for eight months six years before developed. One subject, although 11 without symptoms,...
Abstract Objectives The association of B cell targeted therapies with development hypogammaglobulinaemia and infection is increasingly recognized. Our aim was to develop consensus recommendations for immunoglobulin replacement therapy management following in autoimmune rheumatic diseases. Methods A modified Delphi exercise involved a 17-member Taskforce committee, consisting immunologists, rheumatologists, nephrologists, haematologists, gastroenterologist, an immunology specialist nurse...
Despite the substantial global burden of disease, rheumatic heart disease research receives little funding globally. Using data from Global Burden Disease Study and G-FINDER database, we propose a novel logarithmic disability neglect index (DNI) to describe using disability-adjusted life years relative for 16 major tropical diseases. Across range diseases, received least (DNI=3.83). Other diseases facing similar underfunding include cysticercosis (DNI=2.71) soil-transmitted helminths...
To develop a regional model of COVID-19 dynamics for use in estimating the number infections, deaths and required acute intensive care (IC) beds using South West England (SW) as an example case.
Treatment of chronic obstructive pulmonary disease (COPD) with inhaled and oral corticosteroids is common, although their exact role unclear. Previous studies suggest these drugs may reduce decline in lung function this group patients. We report a study investigating the effect beclomethasone diproprionate (BDP) on symptoms patients COPD. was given for 2 years, FEV 1 individual calculated over period. Ninety‐eight were randomized study, 59 completing years treatment. Patients withdrawn had...
If asthma is due to work exposures there must be a relation between these and the asthma. Asthma causes airway hyperresponsiveness obstruction; obstruction can measured with portable meters, which usually measure peak expiratory flow, or sometimes forced volume in 1 second (FEV1). These serially (for instance 2 hourly) over several weeks at away from work. Once occupational develops, will induced by many non-specific triggers common non-occupational The challenge identify changes flow among...
<h3>ABSTRACT</h3> Therapeutic immunoglobulin G (IgG) products are produced from numerous plasma donations, and infused in many medical conditions. The serological testing of patients who have received IgG infusions may well produce falsely positive misleading results this IgG, rather than endogenously IgG. We present two example cases clinical situations where could cause concern. tested multiple with a range tests performed infective or autoimmune conditions, including hepatitis B,...
Anaphylaxis is increasing in incidence. This potentially fatal condition requires immediate intramuscular adrenaline as a vital part of early treatment. A 2002 survey UK Senior House Officers showed lack knowledge regarding the recognition and management anaphylaxis. Since then major changes medical education updated national guidelines have aimed to ensure that doctors can recognise treat anaphylaxis appropriately.To determine current concerning among junior compared their...
Goiter is a common condition and can cause upper airway obstruction (UAO), which may be difficult to detect. We have studied maximal expiratory inspiratory flow volume loops using neural network see if this offers better way identify patients with UAO. The flow-volume from 155 goiter were assessed by human expert sorted into those without reliability of assessment was judged two observers who repeated the sorting 8 wk apart. A set 46 suggesting UAO 51 normal taken these 155, further 50...
Journal Article Pyoderma gangrenosum‐like ulcer caused by Helicobacter cinaedi in a patient with x‐linked agammaglobulinaemia Get access J. Dua, Dua Departments of Immunology,*Dermatology, †Microbiology, and ‡Histopathology, Barts the London NHS Trust, London, UK Dr Janet c/o Hilary Longhurst, 2nd Floor, Pathology Pharmacy Building, The Royal Hospital, 80 Newark Street, E1 2ES, E‐mail: janetdua3000@yahoo.co.uk Search for other works this author on: Oxford Academic Google Scholar E. Elliot,...
In Malawi, 236 participants from the Advancing Cryptococcal Meningitis Treatment for Africa trial were followed 12 months. The outcomes reported at 10 weeks sustained to 1 year. One-week amphotericin B plus flucytosine was associated with lowest year mortality (27.5% [95% confidence interval, 16.3 44.1]).
Common variable immunodeficiency (CVID) is the most common severe primary immunodeficiency, but pathology of this condition poorly understood. CVID involves a defect in production immunoglobulin from B cells, with subsequent predisposition to infections. Approximately 10-20% cases are inherited, even families genetic penetrance far complete. A classification system for has been suggested (EUROclass) based on cell immunophenotyping, it not shown that altered immunophenotype consequence...
We present a serendipitous case of clinically significant pan-hypogammaglobulinaemia, diagnosed after routine serological testing for possible coeliac disease led first to identification IgA deficiency (discovered as low background in IgA-based screening), and subsequently confirmed pan-hypogammaglobulinaemia (antibody immunodeficiency). Hypogammaglobulinaemia is relatively rare diagnosis (estimated at 1 36,000), which delayed treatment are associated with chronic organ damage including...
We have studied the temperature of expired air during a maximal forced expiratory manoeuvre, because this has not previously been fully investigated and it will influence how flow volume recording devices should be calibrated used. Temperature was recorded with fine thermocouple, response time which determined at various gas velocities for correction made. Recordings manoeuvres were made on 12 normal subjects chronic airflow limitation. The thermocouple placed in mouthpiece, so that level...