A5056467046- COVID-19 Clinical Research Studies
- Drug-Induced Adverse Reactions
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 detection and testing
- Pharmacovigilance and Adverse Drug Reactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Urticaria and Related Conditions
- Bone Tumor Diagnosis and Treatments
- Mast cells and histamine
- Autoimmune Bullous Skin Diseases
- Viral Infections and Immunology Research
- Contact Dermatitis and Allergies
- Hemoglobinopathies and Related Disorders
- Respiratory viral infections research
- Antimicrobial Resistance in Staphylococcus
- Musculoskeletal synovial abnormalities and treatments
- Insect and Pesticide Research
- Tuberculosis Research and Epidemiology
- Malaria Research and Control
- Pharmaceutical studies and practices
- Inflammatory Myopathies and Dermatomyositis
- Antibiotic Use and Resistance
- Allergic Rhinitis and Sensitization
University Hospitals Birmingham NHS Foundation Trust
2020-2023
Heartlands Hospital
2023
NIHR Surgical Reconstruction and Microbiology Research Centre
2020-2021
Imperial College London
2012
Abstract In March 2020, the United Kingdom Primary Immunodeficiency Network (UKPIN) established a registry of cases to collate outcomes individuals with PID and SID following SARS-CoV-2 infection treatment. A total 310 in or have now been reported UK. The overall mortality within cohort was 17.7% (n = 55/310). Individuals CVID demonstrated an fatality rate (IFR) 18.3% 17/93), receiving IgRT had IFR 16.3% 26/159) SID, 27.2% 25/92). higher inpatient died at younger age than general population....
<h3>ABSTRACT</h3> SARS-CoV-2 serological tests are a subject of intense interest and have the potential to significantly enhance diagnostic capability healthcare services in current pandemic. However, as with all novel assays, significant validation is required understand clinical relevance results. We present first study assess clinician interpretation serology scenarios. identify common key assumptions regarding patient infectivity protection that not currently supported by evidence base....
The global polio eradication campaign has had remarkable success in reducing wild-type poliovirus infection, largely built upon the live attenuated Sabin oral vaccine. Whilst rare, vaccine strains may cause infection and subsequently revert to a neurovirulent type, termed vaccine-derived (VDPV). Persistent, derived occur an immunocompromised host (iVDPV), where it is recognised complication following receipt of This significant implications for there currently no agreed strategy manage such...
Abstract Purpose To define the burden of morbidity and mortality arising from COVID-19 in individuals with primary (PID) secondary immunodeficiency (SID) United Kingdom. Methods In March 2020, Kingdom Primary Immunodeficiency Network (UKPIN) established a registry cases to collate outcomes PID SID following SARS-CoV-2 infection treatment. Anonymised demographic data, pre-SARS-CoV-2 lymphocyte counts, co-morbidities, targeted treatments were collected. Three groups analysed further detail:...
A systemically well 11-year-old girl presented with a long history of bilateral ankle swelling (figure 1). Palpation revealed soft, circumscribed masses anterior to each the lateral malleoli, accompanied by smaller swellings over fifth metatarsal heads. Gait and range movement were unaffected. Investigations largely unremarkable, but ultrasound …
Abstract Background The EXENT® (GAM) assay is a MALDI-TOF (Matrix Assisted Laser Desorption Ionisation Time of Flight) mass spectrometry-based solution which utilises IgG, IgA, IgM, total kappa and lambda specific paramagnetic beads, could be used in the investigation monoclonal proteins multiple myeloma other plasma cell disorders (in development by Binding Site (TBS), part Thermo Fisher Scientific). Rare cases IgD IgE myelomas will partially typed with current iteration EXENT assay. We...