A5062271778- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Stroke Rehabilitation and Recovery
- Blood disorders and treatments
- Autoimmune Bullous Skin Diseases
- Musculoskeletal pain and rehabilitation
- SARS-CoV-2 and COVID-19 Research
- Obesity, Physical Activity, Diet
- Smoking Behavior and Cessation
- SARS-CoV-2 detection and testing
- Urticaria and Related Conditions
- Cardiovascular and exercise physiology
- Cardiac Ischemia and Reperfusion
- Congenital Ear and Nasal Anomalies
- Foot and Ankle Surgery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Myofascial pain diagnosis and treatment
- Diabetes Management and Education
- Diabetic Foot Ulcer Assessment and Management
- Long-Term Effects of COVID-19
- Occupational Health and Performance
- Autoimmune and Inflammatory Disorders
- Cerebral Palsy and Movement Disorders
- Global Health Workforce Issues
Edinburgh Royal Infirmary
2019-2025
NHS Lothian
2018-2024
NHS Education for Scotland
2023
Toronto Public Health
2020
Queen's University
2014
University Hospitals of Leicester NHS Trust
2009
Leicester Royal Infirmary
2009
Ruchill Hospital
1989
University of Wales
1989
OBJECTIVE-To assess the risk of cardiorespiratory symptoms and mortality in non-smokers who were passively exposed to environmental smoke.Prospective study cohort from general population first screened between 1972 1976 followed up for an average 11.5 years, with linkage data participants same household.Renfrew Paisely, adjacent burghs urban west Scotland.15,399 Men women (80% all those aged 45-64 resident Renfrew or Paisley) comprised original cohort; 7997 attended multiphasic screening a...
Abstract Background Acquired angioedema due to C1-inhibitor deficiency (AAE-C1-INH) is very rare compared its prototype, hereditary angioedema. An updated characterisation of the AAE-C1-INH cohort in UK required inform management. Objectives To describe disease burden AAE-C1-INH, long-term prophylaxis (LTP) and clinical, immunochemical treatment profiles AAE-associated diseases UK. Method Retrospective data on 117 patients were collected using a national survey proforma across 25/34 Adult...
This is the second report of United Kingdom Primary Immunodeficiency (UKPID) registry. The registry will be a decade old in 2018 and, as August 2017, had recruited 4758 patients encompassing 97% immunology centres within Kingdom. represents doubling recruitment into since we reported on 2229 included our first 2013. Minimum PID prevalence currently 5·90/100 000 and an average incidence between 1980 2000 7·6 cases per 100 UK live births. Data are presented frequency diseases recorded, disease...
Abstract In March 2020, the United Kingdom Primary Immunodeficiency Network (UKPIN) established a registry of cases to collate outcomes individuals with PID and SID following SARS-CoV-2 infection treatment. A total 310 in or have now been reported UK. The overall mortality within cohort was 17.7% (n = 55/310). Individuals CVID demonstrated an fatality rate (IFR) 18.3% 17/93), receiving IgRT had IFR 16.3% 26/159) SID, 27.2% 25/92). higher inpatient died at younger age than general population....
Ataxia-Telangiectasia (A-T) is a genetic condition leading to neurological defects and immune deficiency. The nature of the deficiency highly variable, in some cases causes significant morbidity mortality due recurrent sinopulmonary infections. Although A-T are progressive, natural history has not been evaluated formally. In this study we analyse clinical immunological data 44 patients with who attended National clinic Nottingham between 2001 2011. Using patient medical records University...
Detailed demographic data on people with hereditary angioedema (HAE) and acquired C1 inhibitor deficiency in the United Kingdom are relatively limited. Better would be beneficial planning service provision, identifying areas of improvement, improving care.To obtain more accurate demographics HAE Kingdom, including treatment modalities services available to patients.A survey was distributed all centers that look after patients collect these data.The identified 1152 HAE-1/2 (58% female 92%...
Abstract CHARGE syndrome comprises coloboma of the eye, heart defects, choanal atresia, growth and developmental retardation, genitourinary anomalies ear hearing defects. The association between T‐cell immunodeficiency is recognized, but has not been reported widely in literature. We report four patients meeting diagnostic criteria for syndrome, who had moderate or severe lymphopenia complicated by infections. presented Leicester, UK, 2000 2007. All were negative 22q11.2 deletions FISH...
SARS-CoV-2 antibody tests have been marketed to diagnose previous infection and as a test of immune status. There is lack evidence on the performance clinical utility these tests. We aimed carry out an evaluation 14 point care (POC) Serum from participants with RT-PCR (real-time polymerase chain reaction) confirmed pre-pandemic serum controls were used determine specificity sensitivity each POC device. Changes in increasing time determined cohort study participants. Corresponding...
Objectives To evaluate the lived experiences of doctors from minority ethnic (ME) backgrounds during postgraduate medical training, in particular their discrimination (if any); any impact intersectionality and perceptions on how ME may be better supported learning working environments. Design This was a qualitative study grounded social constructivism, using semi-structured online individual interviews as data collection method an exploratory thematic analysis process. Setting Participants...
Objective: Constraint Induced Movement Therapy has been found to be a promising treatment for substantially improving the use of extremities affected by neurologic injuries such as stroke and traumatic brain injury in adults. The purpose this study was determine applicability child friendly form CI on young children with cerebral palsy. Method: Thirty Children hemiplegic Cerebral Palsy age 4-8 years received completed evaluations. They were randomized either Group A or B. In both groups wore...
Abstract Purpose To define the burden of morbidity and mortality arising from COVID-19 in individuals with primary (PID) secondary immunodeficiency (SID) United Kingdom. Methods In March 2020, Kingdom Primary Immunodeficiency Network (UKPIN) established a registry cases to collate outcomes PID SID following SARS-CoV-2 infection treatment. Anonymised demographic data, pre-SARS-CoV-2 lymphocyte counts, co-morbidities, targeted treatments were collected. Three groups analysed further detail:...
Background: The HIV epidemic poses significant challenges to the healthcare providers including Physiotherapists. study aimed at investigating extent which Physiotherapy College students know about human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) transmission, infection and prevention, transfer of such knowledge sexual behavior change & whether has any influence on attitude willingness treat HIV/AIDS patients.Methods: A cross-sectional survey was carried out...
Connective tissue diseases (CTDs) are characterized by immune system dysregulation, circulating autoantibodies and multisystem disease.Diagnosis is made using both clinical serological features.Renal involvement-manifesting as renal failure or urine dipstick abnormalities-may be the presenting feature of CTD.Renal general physicians need to have a good understanding how testing can help in diagnosis CTD.Here we consider anti-nuclear antibody (ANA) extractable nuclear antigen (ENA) aid CTD...