A5006374434- Immunodeficiency and Autoimmune Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Chronic Myeloid Leukemia Treatments
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Drug-Induced Adverse Reactions
- Conflict of Laws and Jurisdiction
- Burkholderia infections and melioidosis
- Copyright and Intellectual Property
- Chronic Lymphocytic Leukemia Research
- Allergic Rhinitis and Sensitization
- Hepatitis Viruses Studies and Epidemiology
- Venous Thromboembolism Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- Hemophilia Treatment and Research
- Vasculitis and related conditions
- Aortic aneurysm repair treatments
- Plant Pathogenic Bacteria Studies
- Family Support in Illness
- Insect symbiosis and bacterial influences
- Grief, Bereavement, and Mental Health
- Colorectal and Anal Carcinomas
Barts Health NHS Trust
2022-2025
Royal London Hospital
2023-2024
Homerton University Hospital NHS Foundation Trust
2023-2024
University College London
2021-2024
Royal Free London NHS Foundation Trust
2024
The Royal Free Hospital
2023
National Health Service
2023
Nationwide Children's Hospital
2023
Epsom and St Helier University Hospitals NHS Trust
2021-2022
St Helier Hospital
2021
Abstract Background Acquired angioedema due to C1-inhibitor deficiency (AAE-C1-INH) is very rare compared its prototype, hereditary angioedema. An updated characterisation of the AAE-C1-INH cohort in UK required inform management. Objectives To describe disease burden AAE-C1-INH, long-term prophylaxis (LTP) and clinical, immunochemical treatment profiles AAE-associated diseases UK. Method Retrospective data on 117 patients were collected using a national survey proforma across 25/34 Adult...
Abstract In March 2020, the United Kingdom Primary Immunodeficiency Network (UKPIN) established a registry of cases to collate outcomes individuals with PID and SID following SARS-CoV-2 infection treatment. A total 310 in or have now been reported UK. The overall mortality within cohort was 17.7% (n = 55/310). Individuals CVID demonstrated an fatality rate (IFR) 18.3% 17/93), receiving IgRT had IFR 16.3% 26/159) SID, 27.2% 25/92). higher inpatient died at younger age than general population....
Patients with antibody deficiency respond poorly to coronavirus disease 2019 (COVID-19) vaccination and are at risk of severe or prolonged infection. They given long-term immunoglobulin replacement therapy (IRT) prepared from healthy donor plasma confer passive immunity against Following widespread COVID-19 alongside natural exposure, we hypothesized that preparations will now contain neutralizing acute respiratory syndrome 2 (SARS-CoV-2) spike antibodies, which protection may help treat chronic
Burkholderia mallei is an infectious intracellular pathogen whose virulence and resistance to antibiotics makes it a potential bioterrorism agent. Given its genetic origin as commensal soil organism, equipped with extensive varied set of adapted mechanisms cope modulate host-cell environments. One essential mechanism constitutes the specialized secretion systems that are designed penetrate membranes insert proteins directly into host cell's cytosol. However, systems' and, in particular,...
Abstract Background Excipients are widely used in pharmaceuticals, detergents, food, and drink because of their properties low toxicity hypoallergenicity. The excipient carboxymethylcellulose is extensively as a thickener foods such baked goods, ice cream, gluten free, reduced fat products, where it may be labeled e-number E466. However, excipients can rarely cause type 1 hypersensitivity reactions. Several publications have described systemic allergy following exposure particularly...
We describe a rare case of 54-year-old female with hairy cell leukemia, who following treatment for neutropenic sepsis, developed an extensive severe maculopapular exanthema perifollicular hemorrhage. Cladribine, cotrimoxazole, allopurinol, domperidone, amikacin, piperacillin/tazobactam, and meropenem had all been given in the 9 days prior to eruption onset. Three months later, drug patch testing/delayed intradermal testing was positive trimethoprim, meropenem, additional evidence penicillin...
Abstract Purpose To define the burden of morbidity and mortality arising from COVID-19 in individuals with primary (PID) secondary immunodeficiency (SID) United Kingdom. Methods In March 2020, Kingdom Primary Immunodeficiency Network (UKPIN) established a registry cases to collate outcomes PID SID following SARS-CoV-2 infection treatment. Anonymised demographic data, pre-SARS-CoV-2 lymphocyte counts, co-morbidities, targeted treatments were collected. Three groups analysed further detail:...
Abstract Background/Aims The immune response to SARS-CoV-2 is known be reduced in the immunocompromised. However, extent which immunity affected by immunosuppression specific disease cohorts remains poorly characterised. Furthermore, implications of ongoing vaccination booster programme require further study. Individuals with lupus nephritis (LN) prolonged high-dose order maintain control, rendering them important study this context. We evaluated nucleocapsid and spike antibody cohort during...
<h3>Introduction</h3> In March 2010 NICE published guidelines for assessment of patients with chest pain recent onset based on their pre-test likelihood (PL) coronary artery disease (CAD). A novel aspect was the use a CT calcium score (CaS) and angiography (CTCA) to exclude CAD in low risk patients. Here we report our experience integrating this approach Rapid Access Chest Pain Clinic (RACPC) over 32 month period. <h3>Methods</h3> Data retrospectively analysed from consecutive attending...
Abstract Background Aortitis is a heterogeneous rare condition causing aortic inflammation, often due to infectious or autoimmune aetiology. Its presentation, diagnosis and optimal management remain poorly understood, requiring multidisciplinary input. With the advent of improved imaging techniques, an increasing number radiology reports are identifying features vasculitis necessitating clinical investigation. We investigated how cases identified on with aortitis reflected treatment. further...