A5081065187- Inflammatory Bowel Disease
- Microscopic Colitis
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Screening and Detection
- Diagnosis and treatment of tuberculosis
- Gastric Cancer Management and Outcomes
- Enhanced Recovery After Surgery
- Pelvic floor disorders treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Anorectal Disease Treatments and Outcomes
- Gastrointestinal motility and disorders
- Colorectal Cancer Surgical Treatments
- Pregnancy and Medication Impact
- Healthcare cost, quality, practices
- Abdominal Surgery and Complications
- Autoimmune and Inflammatory Disorders
- Diverticular Disease and Complications
- COVID-19 Clinical Research Studies
- Hidradenitis Suppurativa and Treatments
NHS Lothian
2018-2024
Edinburgh Royal Infirmary
1993-2024
Western General Hospital
1989-2024
University of Leicester
2023
Creative Research Enterprises (United States)
2022
Royal Edinburgh Hospital
2022
St James's University Hospital
2019-2020
University of Leeds
2019-2020
University of Edinburgh
2011-2020
Northern General Hospital
1993
Abstract Background Intravenous (IV) steroids remain the first-line treatment for patients with acute ulcerative colitis (UC). However, 30% of do not respond to steroids, requiring second-line therapy and/or surgery. There are no existing indices that allow physicians predict steroid nonresponse at admission. We aimed determine if admission biochemical and endoscopic values could response IV steroids. Methods All admissions UC (ICD-10 K51) between November 1, 2011, October 31, 2016 were...
No standardised method for taste threshold measurement is available and therefore comparison between clinical studies difficult. An electrogustometer was evaluated in normal subjects. sex difference noted; however, there a significant elevation detection with age smoking. Electrogustometric values both patients before after surgery trigeminal neuralgia sensory neuropathy were determined. Many nerve disorders had abnormal electrogustometric thresholds suggesting that possibly an accessory...
Bilateral chorda tympani section is an accepted treatment for troublesome sialorrhoea. Nevertheless the effects of this operation have been poorly studied. Twenty patients were studied with unilateral and a healthy contralateral ear. The on ipsilateral stimulated submandibular parotid flow taste recognition detection thresholds measured. Stimulated accounted only 27% total salivary flow. Chorda had no effect in seven reduced by approximately 54% remaining 13 patients. No significant was...
Many patients with intracranial tumours have cognitive deficits that might affect their mental capacity to give valid consent neurosurgical treatment. The aim of this study was determine the incidence incapacity, as assessed by neurosurgeons, in undergoing neurosurgery.The case notes successive brain tumour surgery between 16 October 2008 and 2010 were reviewed. frequency use standard forms Certificates Incapacity recorded. In addition, scores pre-operative assessments recorded.Case 247 262...
Objective We aimed to investigate the clinical utility of follow-up oesophagogastroduodenoscopy (OGD2) in patients with severe oesophagitis (Los Angeles grades C or D) through evaluating yield Barrett’s oesophagus (BO), cancer, dysplasia and strictures. Second, we determine if Clinical Frailty Scale (CFS) may be used identify undergo OGD2s. Design/method Patients NHS Lothian an index OGD (OGD1) diagnosis between 1 January 2014 31 December 2015 were identified. Univariate analysis identified...
Biological treatment is effective in maintaining remission ulcerative colitis (UC), although the effect on colectomy rates remains unclear. In UK use of antitumour necrosis factor and anti-α4β7 treatments for maintenance therapy UC was restricted until 2015. The aim this study to describe impact that change prescribing biologicals had UC.All patients (adult paediatric) with a diagnosis who received biological and/or underwent Lothian, Scotland between 2005 2018 were identified. Linear...
In 2020 we reported the ACE Index in acute colitis which used biochemical and endoscopic parameters to predict steroid non-response on admission patients with ulcerative [UC]. We aimed validate an independent cohort.
Abstract Aim The aim of this work was to determine the factors associated with poor wound healing in patients perianal Crohn's disease (pCD) who had undergone proctectomy era biologic therapies. Method Case record review performed on 103 pCD underwent at St Mark's Hospital, Harrow and Western General Edinburgh between 2005 2017. Healing rates 6 12 months post‐proctectomy were considered; univariate analysis performed. Results Sixty out (58.3%) failure 41/103 (39.8%) months. In total, 63.1%...
Debate is ongoing regarding the need for universal endoscopic follow-up to ensure gastric ulcer healing. We aimed assess value of oesophago-gastro-duodenoscopies (OGDs) healing and stratify patients according risk malignancy by developing a score.All in National Health Service (NHS) Lothian with an index OGD diagnosis between 1 January 2014 31 December 2018 were identified. Data analysed logistic regression identify factors significantly associated cancer; score was derived externally...
Objective Small-bowel capsule endoscopy (SBCE) is being used with increasing frequency. It important, however, to ensure that the frail elderly in particular are undergoing investigations which have a positive impact on their ongoing management. We aimed determine SBCE rate elderly, clinical outcomes, and if frailty may be tailor SBCE. Design/methods Patients aged ≥65 who had performed at Royal Infirmary of Edinburgh from 1 January 2016 December 2021 were identified. Demographic, results...
Objective In May 2021 we implemented a locally developed gastric ulcer protocol. Patients with low Edinburgh Gastric Ulcer Scores (EGUS) and benign biopsy results at index oesophagogastroduodenoscopy (OGD1) were recommended to not undergo follow-up OGD (OGD2). We aimed validate the EGUS identify any cancer diagnoses since protocol adoption. Design diagnosed OGD1 in NHS Lothian from 24 June 2023 identified. Data regarding rates gathered compared Electronic patient records reviewed for...
BackgroundThe purpose of this study was to determine factors which may be associated with poor wound healing in patients perianal Crohn's disease (pCD) who had undergone proctectomy the biologics era.
<h3>Introduction</h3> About 20% patients with perianal Crohn's (pCD) undergo proctectomy a significant number developing unhealed wounds. The purpose of this study was to determine factors which may be associated poor wound healing in pCD who had undergone the biologics era. <h3>Methods</h3> Case record review carried out 79 underwent at St Mark's Hospital between 2005 and 2017. Healing rates 6 12 months post were considered univariate regression analysis performed. <h3>Results</h3> Complete...
<h3>Introduction</h3> Schizophrenia is a severe mental illness which can have devastating impact on all aspects of an individual's life. Substance misuse (in particular alcohol), risk suicide, and high rates often poorly controlled physical health conditions, resulted in patients having life expectancy reduced by approximately 15 years when compared to the general population. We aimed determine burden gastrointestinal diseases amongst with schizophrenia through consideration those admitted...
<h3>Introduction</h3> In this study we aimed to investigate the clinical utility of follow-up oesophagogastroduodenoscopy (OGD2) in clinically frail patients (according Clinical Frailty Scale) with severe oesophagitis through evaluating, by Los Angeles (LA) grade, yield Barrett's oesophagus (BO), cancer, dysplasia and strictures. <h3>Methods</h3> Patients NHS Lothian an index OGD (OGD1) diagnosis LA grades C or D between 01/01/14–31/12/15 were identified. Univariate analysis identified...
<h3>Introduction</h3> A local 'gastric ulcer follow-up' protocol was developed, externally validated and implemented locally in May 2021. Under the protocol, patients with low risk scores based on size, location patient age benign biopsy results at index oesophagogastroduodenoscopy (OGD1), are not offered endoscopic follow-up to check healing (OGD2). We investigated uptake of this its impact outcomes. <h3>Methods</h3> Patients diagnosed a gastric OGD1 NHS Lothian from 24/5/21–16/1/22 were...
Background Cascade genetic and imaging screening for relatives of people with non-syndromic thoracic aortic diseases (NS-TAD) is recommended by guidelines. However, the availability uptake cascade low. The aim this study was to use applied health research methods identify barriers screening, strategies overcome these. Methods A cohort using routinely collected data evaluated imaging, testing, treatment NS-TAD. Delphi consensus exercises workshops process patient experience. Focus groups...
First-line treatment for ASUC with IV steroids is routinely given in UK hospitals. We sought to establish if initial a tertiary referral centre affected outcome. To this end we examined all admissions within Lothian and compared outcomes between those initially treated at the centre: Western General Hospital (WGH) other two acute hospitals health trust: Royal Infirmary of Edinburgh (RIE) St. John’s (SJH). assessed both response second-line medical therapy but also likelihood requiring...