A5032142715- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Respiratory Support and Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dialysis and Renal Disease Management
- Systemic Sclerosis and Related Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Autoimmune Bullous Skin Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myeloid Leukemia Research
- Intensive Care Unit Cognitive Disorders
- Cancer, Hypoxia, and Metabolism
- Biomedical Research and Pathophysiology
- Airway Management and Intubation Techniques
- COVID-19 and healthcare impacts
- Economic and Financial Impacts of Cancer
- Platelet Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Hemophilia Treatment and Research
- Blood properties and coagulation
University of Manchester
2013-2025
Manchester University NHS Foundation Trust
2015-2025
Manchester Academic Health Science Centre
2019-2025
University of Alberta
2024-2025
Manchester Royal Infirmary
2014-2024
The Royal Free Hospital
2024
Roland Hill (United Kingdom)
2024
University College London
2024
Cardiff University
2024
Wellcome Centre for Cell-Matrix Research
2020-2023
Alternative C activation is involved in the pathogenesis of ANCA-associated vasculitis. However, glucocorticoids used as treatment contribute to morbidity and mortality We determined whether avacopan (CCX168), an orally administered, selective C5a receptor inhibitor, could replace oral without compromising efficacy. In this randomized, placebo-controlled trial, adults with newly diagnosed or relapsing vasculitis received placebo plus prednisone starting at 60 mg daily (control group), (30...
<h3>Importance</h3> In patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear. <h3>Objective</h3> To determine whether low-tidal-volume compared with conventional major surgery decreases postoperative pulmonary complications. <h3>Design, Setting, and Participants</h3> Single-center, assessor-blinded, randomized clinical trial of 1236 older than 40 years undergoing noncardiothoracic, nonintracranial under general anesthesia lasting more 2 hours in a...
Summary. Immunocytochemistry was used to assess bcl‐2 expression in blasts obtained from the bone marrow of 28 patients with acute lymphoblastic leukaemia (ALL) (16 children and six adults at presentation three on relapse) 20 myeloid (AML) (19 one child, 13 de novo AML, 11 two relapse, seven secondary myelodysplasia or chronic leukaemia). Slides were examined both for percentage positive cells intensity staining using a five‐point scale. There statistically significant increase seen (P <...
COVID-19 has spread globally to now be considered a pandemic by the World Health Organisation. Initially patients appeared have respiratory limited disease but there are increasing reports of multiple organ involvement including renal in association with COVID-19. We studied development and outcomes acute kidney injury (AKI) COVID-19, large multicultural city hospital trust UK, better understand role process.This was retrospective review using electronic records laboratory data adult...
Studies in critically ill patients suggest a relationship between mechanical power (an index of the energy delivered by ventilator, which includes driving pressure, respiratory rate, tidal volume and inspiratory pressure) complications.We aimed to assess association intra-operative postoperative pulmonary complications (PPCs).Post hoc analysis large randomised clinical trial.University-affiliated academic tertiary hospital Melbourne, Australia, from February 2015 2019.Adult undergoing major...
With the advent of electronic particle counters Coulter S type mean cell volume (MCV) has become an integral and useful feature red profile. Abnormally high values, often minor degree, are particularly common but their precise clinical significance may be difficult to establish. This study defines normal range determines incidence distribution MCV in routine hospital practice. Two hundred consecutive adult patients with 100 fl or more were identified from analysis 6542 blood samples...
The rising financial burden of cancer on health-care systems worldwide has led to the increased demand for evidence-based research which base reimbursement decisions. Economic evaluations are an integral component this necessary research. Ascertainment reliable cost and quality-of-life estimates inform such studies historically been challenging, but recent advances in informatics United Kingdom provide new opportunities. costs hospital care breast, colorectal prostate disease-free survivors...
The long-term economic and quality-of-life outcomes of patients admitted to intensive care unit (ICU) with acute respiratory distress syndrome are not well understood. In this study, we investigate 1-year costs, survival quality life following ICU admission in who required mechanical ventilation for syndrome. Economic analysis data collected alongside a UK-based multi-centre randomised, controlled trial, aimed at comparing high-frequency oscillatory conventional ventilation. study included...
Abstract Background and hypothesis The PLA2R antibody test is a valuable first-line diagnostic tool for primary membranous nephropathy (MN), helping to identify PLA2R-related MN potentially eliminating the need kidney biopsy in some individuals. By reducing reliance on biopsies, streamlines diagnosis improves patient care. However, determining optimal measurement method cut-off critical maximising benefits of minimising any harms. Methods A systematic review meta-analysis were performed...
Dengue fever is a common cause of acute febrile illness in the tropics and requires hospitalization for intravenous (IV) fluid therapy minority patients. Predicting which patients will progress to severe disease challenging. Soluble tumour necrosis factor receptor 1 (sTNFR1) associated with dengue may have prognostic value. Prospective cohort study outpatients Philippines fever, confirmed by NS1 antigenemia or IgM seropositivity. sTNFR1 was measured at presentation were followed 14-21 days...
One hundred and forty-three multitransfused patients with hereditary haemostatic disorders were examined for evidence of disease related to the acquired immune deficiency syndrome (AIDS). Ninety-nine severe haemophilia A tested anti-HTLV-III 76 found be positive. All except one these seropositive had received commercial factor VIII concentrates at some time. Eighteen B all negative. Three out 36 sexual partners positive also seropositive. One, who recently blood transfusions, AIDS...
Factors V, VII, VIII, X, XI, and XII of the coagulation system, platelet count, antithrombin III levels were assayed in 20 healthy volunteers aged 20-40 years 61 elderly subjects 66-96 whose skinfold thickness was also measured. XII, tended to increase women decrease men while factors V both males females with advancing years. No age or sex differences found counts factor VIII levels. Factor inversely correlated obesity (r = -0.56, p < 0.005).
We present a sensitive and low-cost immunoassay, based on customized open-source quartz crystal microbalance coupled with graphene biointerface sensors (G-QCM), to quantify antibodies in undiluted patient serum. demonstrate its efficacy for specific antibody against the phospholipase A2 receptor (anti-PLA2R), which is biomarker primary membranous nephropathy. A novel graphene–protein was constructed by adsorbing low concentration of denatured bovine serum albumin (dBSA) reduced oxide (rGO)...
Patients with the acute respiratory distress syndrome (ARDS) require artificial ventilation but this treatment may produce secondary lung damage. High-frequency oscillatory (HFOV) reduce damage.To determine clinical benefit and cost-effectiveness of HFOV in patients ARDS compared standard mechanical ventilation.A parallel, randomised, unblinded trial.UK intensive care units.Mechanically ventilated a partial pressure oxygen arterial blood/fractional concentration inspired (P : F) ratio 26.7...
Since the emergence of anti-PLA2R antibody (PLA2R-Ab) test, nephrology practice has not changed dramatically, with most nephrologists still relying on a kidney biopsy to diagnose membranous nephropathy. In this study, we examined clinical accuracy test using ELISA in routine care.We conducted retrospective analysis PLA2R-Ab testing 187 consecutive patients seen at single UK centre between 2003 and 2020. We compared findings PLA2R-ab test. Patients' demography, urine protein creatinine...
Abstract Objectives IgA vasculitis (IgAV) in adults has been relatively under-investigated. Since outcomes are worse other forms of with increasing age, we investigated the IgAV comparing younger (18–34), middle-aged (35–64) and elderly patients (≥64 years) focusing on kidney outcomes. Methods We identified renal biopsy-confirmed nephritis collected data regarding clinical features progression to end stage disease (ESKD). The relationship between patient factors ESKD was analysed by...