A5063700973- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Non-Invasive Vital Sign Monitoring
- Nausea and vomiting management
- Airway Management and Intubation Techniques
- Renal function and acid-base balance
- Intensive Care Unit Cognitive Disorders
- Meta-analysis and systematic reviews
- Blood Pressure and Hypertension Studies
- Climate Change and Health Impacts
- Ultrasound in Clinical Applications
- Cardiac Arrest and Resuscitation
- Abdominal Surgery and Complications
- Health and Medical Research Impacts
- Enhanced Recovery After Surgery
- Atomic and Subatomic Physics Research
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Delphi Technique in Research
- Cardiovascular and Diving-Related Complications
Institute for Breathing and Sleep
2014-2025
Austin Hospital
2016-2025
The University of Melbourne
2016-2025
Austin Health
2014-2025
The Royal Melbourne Hospital
2012-2024
ANZCA Clinical Trials Network
2023
Australian and New Zealand College of Anaesthetists
2003-2023
Monash University
2012-2021
Committee on Publication Ethics
2021
Royal Perth Hospital
2018
Guidelines to promote the early recovery of patients undergoing major surgery recommend a restrictive intravenous-fluid strategy for abdominal surgery. However, supporting evidence is limited, and there concern about impaired organ perfusion.
Background Nitrous oxide is widely used in anesthesia, often administered at an inspired concentration around 70%. Although nitrous interferes with vitamin B12, folate metabolism, and deoxyribonucleic acid synthesis prevents the use of high oxygen concentrations, consequences these effects are unclear. Methods Patients having major surgery expected to last least 2 h were randomly assigned oxide-free (80% oxygen, 20% nitrogen) or oxide-based (70% N2O, 30% oxygen) anesthesia. observers blind...
To compare long term recurrence of cancer and survival patients having major abdominal surgery for cancer.Long follow-up prospective randomised controlled clinical trial in which were randomly assigned to receive general anaesthesia with or without epidural block at least three postoperative days. Setting 23 hospitals Australia, New Zealand, Asia.503 adult who had potentially curative cancer.Cancer-free (analysis was by intention treat).Long data available 94% (n=446) eligible participants....
<h3>Importance</h3> In patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear. <h3>Objective</h3> To determine whether low-tidal-volume compared with conventional major surgery decreases postoperative pulmonary complications. <h3>Design, Setting, and Participants</h3> Single-center, assessor-blinded, randomized clinical trial of 1236 older than 40 years undergoing noncardiothoracic, nonintracranial under general anesthesia lasting more 2 hours in a...
In a primary analysis of large recently completed randomized trial in 915 high-risk patients undergoing major abdominal surgery, we found no difference outcome between receiving perioperative epidural analgesia and those IV opioids, apart from the incidence respiratory failure. Therefore, performed selected number predetermined subgroup analyses to identify specific types who may have derived benefit analgesia. We control groups subgroups at increased risk or cardiac complications aortic nor...
In a primary analysis of large recently completed randomized trial in 915 high-risk patients undergoing major abdominal surgery, we found no difference outcome between receiving perioperative epidural analgesia and those IV opioids, apart from the incidence respiratory failure. Therefore, performed selected number predetermined subgroup analyses to identify specific types who may have derived benefit analgesia. We control groups subgroups at increased risk or cardiac complications aortic nor...
In Brief BACKGROUND: There is a plausible pathophysiologic rationale for increased long-term cardiovascular morbidity and mortality in patients receiving significant exposure to nitrous oxide. However, this relationship has not been established clinically. The ENIGMA trial randomized 2050 having noncardiac surgery lasting more than 2 hours oxide–based or oxide–free anesthesia. We conducted follow-up study of the evaluate risk events longer term. METHODS: case report forms medical records all...
Studies in critically ill patients suggest a relationship between mechanical power (an index of the energy delivered by ventilator, which includes driving pressure, respiratory rate, tidal volume and inspiratory pressure) complications.We aimed to assess association intra-operative postoperative pulmonary complications (PPCs).Post hoc analysis large randomised clinical trial.University-affiliated academic tertiary hospital Melbourne, Australia, from February 2015 2019.Adult undergoing major...
Emerging technologies that reduce the economic and environmental costs of anaesthesia have had limited assessment. We hypothesised automated control end-tidal gases, a new feature in machines, will consistently volatile agent consumption cost greenhouse gas emissions. As part planned replacement machines tertiary hospital, we performed prospective before after study comparing emissions isoflurane, sevoflurane desflurane when using manual versus gases. analysed 3675 general cases with...
Introduction The optimal intravenous fluid regimen for patients undergoing major abdominal surgery is unclear. However, results from many small studies suggest a restrictive may lead to better outcomes. A large, definitive clinical trial evaluating perioperative replacement in surgery, therefore, required. Methods/analysis We designed pragmatic, multicentre, randomised, controlled (the RELIEF trial). total of 3000 were enrolled this study and randomly allocated or liberal 1:1 ratio,...
Abstract Background The Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial randomly assigned 7,112 noncardiac surgery patients at risk perioperative cardiovascular events to 70% N2O or N2 groups. aim this follow-up study was determine effect nitrous oxide on a composite primary outcome death and major 1 yr after surgery. Methods One-year conducted via medical record review telephone interview. Disability defined as Katz index independence activities daily living...