A5022650388- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Opioid Use Disorder Treatment
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Substance Abuse Treatment and Outcomes
- Memory and Neural Mechanisms
- Heart Rate Variability and Autonomic Control
- Treatment of Major Depression
- Cognitive Science and Mapping
- Neuroendocrine regulation and behavior
- Neurological disorders and treatments
- Health and Medical Research Impacts
- Health Sciences Research and Education
- Smoking Behavior and Cessation
- Chronic Disease Management Strategies
- Nicotinic Acetylcholine Receptors Study
- Vagus Nerve Stimulation Research
- Behavioral Health and Interventions
- Schizophrenia research and treatment
- Neuroscience and Music Perception
- EEG and Brain-Computer Interfaces
- Medication Adherence and Compliance
Agency for Science, Technology and Research
2022-2024
Institute of High Performance Computing
2022-2024
National University of Singapore
2019-2023
American Society of Addiction Medicine
2022-2023
University of Dundee
2013-2019
University of St Andrews
2019
Ninewells Hospital
2013-2018
Education Scotland
2014
University of Milano-Bicocca
2013
Converging evidence has linked the anterior mid-cingulate cortex to negative affect, pain and cognitive control. It previously been proposed that this region uses information about punishment control aversively motivated actions. Studies on effects of lesions allow causal inferences brain function; however, naturally occurring in are rare. In two studies we therefore recruited 94 volunteers, comprising 15 patients with treatment-resistant depression who had received bilateral cingulotomy,...
COVID-19 and Substance Use Disorders: Recommendations to a Comprehensive Healthcare Response. An International Society of Addiction Medicine (ISAM) Practice Policy Interest Group Position Paper
The application of machine learning techniques to psychiatric neuroimaging offers the possibility identify robust, reliable and objective disease biomarkers both within between contemporary syndromal diagnoses that could guide routine clinical practice. use quantitative methods is consequently important, particularly with a view making predictions relevant individual patients, rather than at group-level. Here, we describe treatment-refractory depression (TRD) diagnosis using structural...
Background Chronic opioid exposure, as a treatment for variety of disorders or drug misuse, is common worldwide, but behavioural and brain abnormalities remain under-investigated. Only small percentage patients who receive methadone maintenance (MMT) previous heroin misuse eventually achieve abstinence studies on such are rare. Method The Cambridge Neuropsychological Test Automated Battery T 1 weighted magnetic resonance imaging (MRI) were used to study cohort 122 male individuals:...
Major depressive disorder is characterized by anhedonia, cognitive biases, ruminations, hopelessness and increased anxiety. Blunted responses to rewards have been reported in a number of recent neuroimaging behavioural studies major disorder. In contrast, neural aversive events remain an under-studied area. While selective serotonergic reuptake inhibitors are often effective treating disorder, their mechanism action remains unclear. Following series animal model investigations illness...
Addiction medicine is a rapidly growing field with many young professionals seeking careers in this field. However, early-career (ECPs) face challenges such as lack of competency-based training due to shortage trainers, limited resources, mentorship opportunities, and establishment suitable research areas. The International Society Medicine (ISAM) New Professionals Exploration, Training & Education (NExT) committee, global platform for addiction (ECAMPs), conducted two-phase online survey...
Glioblastoma multiforme (GBM) is one of the most aggressive forms cancer. Neurotransmitters (NTs) have recently been linked with uncontrolled proliferation cancer cells, but role NTs in progression human gliomas still largely unexplored. Here, we investigate genes encoding for neurotransmitter receptors (NTRs) by analyzing public transcriptomic data from GBM and LGG (low-grade glioma) samples. Our results showed that 50 out 98 tested NTR were dysregulated brain tissue. Next, identified...
Abstract Background Internet gaming disorder (IGD) is a type of behavioural addictions. One the key features addiction excessive exposure to addictive objectives (e.g. drugs) reduces sensitivity brain reward system daily rewards money). This thought be mediated via signals expressed as dopaminergic prediction error (RPE). Emerging evidence highlights blunted RPE in drug However, no study has examined whether IGD also involves alterations that are observed other types Methods To fill this...
Abstract Background Chronic opioid exposure is common world-wide, but behavioural performance remains under-investigated. This study aimed to investigate visuospatial memory in opioid-exposed and dependent clinical populations its associations with measures of intelligence cognitive impulsivity. Methods We recruited 109 participants: (i) patients a history dependence due chronic heroin use ( n = 24), (ii) users stabilised on methadone maintenance treatment 29), (iii) participants pain...
Abstract Opioid use disorder (OUD) affects more than 27 million people globally accounting for 300,000 deaths annually. Protracted abstinence among individuals with OUD is rare due to a high relapse rate those not receiving medications OUD. Extensive preclinical studies form the basis of allostasis theory, which proposes long-lasting functional brain abnormalities that persist after opioid withdrawal and contribute relapse. Few have tested theory in humans using neuroimaging. Here, we used...
Alcohol-related morbidities and mortality are highly prevalent, increasing the burden to societies health systems with 3 million deaths globally each year in young adults directly attributable alcohol. Cue-induced alcohol craving has been formulated as a type of aberrant associative learning, modeled using temporal difference theory an expected reward value (ERV) linked craving. Clinically, although harmful use is associated increased time spent obtaining alcohol, it also self-neglect. The...
System-justifying ideologies are a cluster of ideals that perpetuate hierarchical social system despite being fraught with inequalities. Right-wing authoritarianism (RWA) and dominance orientation (SDO) two have received much attention in the literature separately together. Given these considered to be stable individual differences likely an evolutionary basis, there has yet any examination for volumetric brain structures associated variables. Here, we proposed investigation overlapping...
Introduction: The cognitive impact of opioid dependence is rarely measured systematically in everyday clinical practice even though both patients and clinicians accept that symptoms often occur the opioid-dependent population. There are only a few publications which utilized computerized neuropsychological tests to assess possible impairments visuospatial memory individuals either receiving replacement therapy (ORT) or during subsequent short-term abstinence effects anxiety depression....