A5054324011- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Pneumocystis jirovecii pneumonia detection and treatment
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Biochemical and Molecular Research
- Parvovirus B19 Infection Studies
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Molecular Biology Techniques and Applications
- Viral Infections and Outbreaks Research
- Adolescent Sexual and Reproductive Health
- Vaccine Coverage and Hesitancy
- Virology and Viral Diseases
- Immunotherapy and Immune Responses
- HIV/AIDS Impact and Responses
Royal Free London NHS Foundation Trust
2008-2025
King's College London
2021-2025
University of Rome Tor Vergata
2021-2025
Policlinico Tor Vergata
2021-2025
Middlesex University
2023-2024
North Middlesex Hospital
2023-2024
Brighton and Sussex Medical School
2024
University of Liverpool
2013-2022
University of Cambridge
2022
Kamuzu Central Hospital
2022
<h3>Importance</h3> A key factor in assessing the effectiveness and cost-effectiveness of antiretroviral therapy (ART) as a prevention strategy is absolute risk HIV transmission through condomless sex with suppressed HIV-1 RNA viral load for both anal vaginal sex. <h3>Objective</h3> To evaluate rate within-couple (heterosexual men who have [MSM]) during periods without condoms when HIV-positive partner had less than 200 copies/mL. <h3>Design, Setting, Participants</h3> The prospective,...
The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy (ART) is limited compared available heterosexual couples. aim second phase PARTNER study (PARTNER2) was to provide precise estimates partnerships.The a prospective observational done at 75 sites 14 European countries. first (PARTNER1; Sept 15, 2010, May 31, 2014) recruited and followed up both (HIV-positive ART)...
Abstract An excess of coinhibitory signals has been proposed to drive the T-cell exhaustion characteristic persistent viral infections. In this study we examined contribution receptor cytotoxic T lymphocyte antigen-4 (CTLA-4) CD8 cell tolerance in chronic hepatitis B virus (HBV) infection (CHB). cells patients with CHB have an increased propensity express CTLA-4 and correlates load. is up-regulated on those HBV-specific highest levels proapoptotic protein Bim, which previously shown mediates...
Recreational drug use in men who have sex with (MSM) is of concern because it might be linked to the transmission HIV and other sexually transmitted infections. Evidence about HIV-diagnosed MSM UK limited by representativeness study populations. We describe patterns associations sexual behaviours UK.We used data from cross-sectional ASTRA study, which recruited participants aged 18 years or older eight outpatient clinics between Feb 1, 2011, Dec 31, 2012. examined for MSM, assessing...
Abstract Background Evidence is conflicting about how human immunodeficiency virus (HIV) modulates coronavirus disease 2019 (COVID-19). We compared the presentation characteristics and outcomes of adults with without HIV who were hospitalized COVID-19 at 207 centers across United Kingdom whose data prospectively captured by International Severe Acute Respiratory Emerging Infection Consortium (ISARIC) World Health Organization (WHO) Clinical Characterization Protocol (CCP) study. Methods used...
The overall purpose of these guidelines is to provide guidance on best clinical practice in the treatment and management adults with HIV infection antiretroviral therapy (ART). scope includes: (i) initiation ART those previously naïve therapy; (ii)support patients treatment; (iii) experiencing virological failure; (iv) recommendations specific patient populations where other factors need be taken into consideration. are aimed at professionals directly involved responsible for care community...
Immunological correlates of AIDS-free survival after human immunodeficiency virus type 1 (HIV-1) infection are largely unknown. Cytotoxic T lymphocyte (CTL) responses generally believed to be a major component protective immunity against viral infections. However, the relationship between HIV-1-specific CTL and disease progression rate is presently unclear. Here we show in twelve HIV-1-infected individuals that detection Rev-specific precursors (CTLp) early asymptomatic stage, as well Rev-...
Table of Contents 1. Levels evidence 1.1 Reference 2. Introduction 3. Auditable targets 4. summaries 4.1 Initial diagnosis 4.2 Assessment ART‐naïve individuals 4.3 ART initiation 4.4 assessment following commencement 4.5 Routine monitoring on 4.6 References 5. Newly diagnosed and transferring HIV‐positive 5.1 HIV‐1 5.2 Tests to determine whether acquisition HIV infection is recent 5.3 Individuals care from a different healthcare setting 5.4 Communication with general practitioners shared 5.5...
Introduction Scope and purpose Methodology Guideline development process Patient involvement GRADE Good practice points Dissemination implementation updates date of next review Treatment aims Resource use Implications for research References Recommendations auditable outcomes (GRADE) in decision making (Section 3) When to start 4) What 5) Supporting patients on therapy 6) Managing virological failure 7) Antiretroviral therapies specific populations 8) Summary measures decision-making...
Objective To examine whether the level of primary resistance to HIV drugs is increasing in United Kingdom.
Background. Plasma human immunodeficiency virus type 1 (HIV-1) RNA suppression <50 copies/mL is regarded as the optimal outcome of highly active antiretroviral therapy (HAART). Current viral load (VL) assays show increased sensitivity, but significance detection unclear.
Background Our intention was to compare the rate of immunological progression prior antiretroviral therapy (ART) and virological response ART in patients infected with subtype B four non‐B HIV‐1 subtypes (A, C, D circulating recombinant form, CRF02‐AG) an ethnically diverse population HIV‐1‐infected south London. Methods A random sample 861 attending HIV clinics at King's St Thomas' hospitals' were subtyped using in‐house enzyme‐linked immunoassay env sequencing. Subtypes compared on CD4...
It has been proposed that subtype-related human immunodeficiency virus type 1 (HIV-1) variability may influence virologic and immunologic responses to highly active antiretroviral therapy (HAART). Studies date, however, have described treatment outcomes predominantly in persons with subtype B infection or compared diverse non-B subtypes grouped together.With use of data from the linked UK Collaborative Group on HIV Drug Resistance Cohort Study databases, time viral load undetectability...
BackgroundViral meningitis is increasingly recognised, but little known about the frequency with which it occurs, or causes and outcomes in UK. We aimed to determine incidence, causes, sequelae UK adults improve management of patients assist health service planning.MethodsWe did a multicentre prospective observational cohort study suspected at 42 hospitals across England. Nested within this study, National Health Service (NHS) northwest region (now part NHS England North), was an...
It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect the virological outcomes of first-line NNRTI-containing ART.This Europe-wide case-control study included ART-naive subjects infected with drug-susceptible as revealed by population sequencing, who achieved suppression on ART including one NNRTI. Cases experienced failure and controls were from same cohort whose viraemia remained suppressed at a matched time since initiation ART. Blinded, centralized 454...
Genital herpes is one of the commonest sexually transmitted infections worldwide. Using best available evidence, this guideline recommends strategies for diagnosis, management, and follow-up condition as well minimising transmission. Early recognition initiation therapy key may reduce duration illness or avoid hospitalisation with complications, including urinary retention, meningism, severe systemic illness. The covers a range common clinical scenarios, such recurrent genital herpes,...
BackgroundFew studies have assessed the effect of socioeconomic status on HIV treatment outcomes in settings with universal access to health care. Here we aimed investigate association factors antiretroviral therapy (ART) non-adherence, virological non-suppression, and rebound, HIV-positive people ART UK.MethodsWe used data from Antiretrovirals, Sexual Transmission Risk Attitudes (ASTRA) questionnaire study, which recruited participants aged 18 years or older eight outpatient clinics UK...
Little is known about the long term risk of development HIV-1 drug resistance for patients starting antiretroviral therapy (ART) with three or four regimens in routine clinical practice.We analysed a large cohort study seen one six HIV clinics and around London, UK. The focus this analysis was on who started ART two nucleosides plus either single protease inhibitor (PI), PI ritonavir, abacavir non-nucleoside reverse transcriptase (NNRTI).4306 were followed; 1436 (33%) PI, 279 (6%) 156 (4%)...