A5077595049- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Respiratory viral infections research
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Neonatal Respiratory Health Research
- Viral-associated cancers and disorders
- Viral gastroenteritis research and epidemiology
- Congenital Diaphragmatic Hernia Studies
- Parvovirus B19 Infection Studies
- T-cell and Retrovirus Studies
- Hepatitis Viruses Studies and Epidemiology
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Immunology Research
- COVID-19 and healthcare impacts
- Animal Virus Infections Studies
- Biosensors and Analytical Detection
- Pediatric health and respiratory diseases
King's College Hospital
2013-2024
King's College Hospital NHS Foundation Trust
2013-2024
King's College London
2000-2024
Public Health England
2016-2020
University of Cambridge
2014-2015
Norwegian Institute of Public Health
2009-2010
University College London
1995-2008
King's College - North Carolina
2002-2008
Health Protection Agency
2006
Hy-Line (United States)
2005
Encephalitis has many causes, but for most patients the cause is unknown. We aimed to establish and identify clinical differences between causes in with encephalitis England.Patients of all ages symptoms suggestive were actively recruited 2 years (staged start October, 2005, November, 2006) from 24 hospitals by staff. Systematic laboratory testing included PCR antibody assays commonly recognised infectious encephalitis, investigation less immunocompromised patients, travel-related if...
Objective To examine whether the level of primary resistance to HIV drugs is increasing in United Kingdom.
Background Our intention was to compare the rate of immunological progression prior antiretroviral therapy (ART) and virological response ART in patients infected with subtype B four non‐B HIV‐1 subtypes (A, C, D circulating recombinant form, CRF02‐AG) an ethnically diverse population HIV‐1‐infected south London. Methods A random sample 861 attending HIV clinics at King's St Thomas' hospitals' were subtyped using in‐house enzyme‐linked immunoassay env sequencing. Subtypes compared on CD4...
These evidence-based guidelines expand and adapt previous guidance (Tomblyn et al, 2009; Andrews 2011). While specifically focusing on allogeneic haemopoietic stem cell transplantation (HSCT), they are relevant to other areas of haematological oncology where there is an increased risk cytomegalovirus (CMV) infection, such as cancers intense anti-T-cell therapy has been deployed (O'Brien 2006). The production these involved the following steps: CMV a herpes virus. Primary infection followed...
There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in absence selective pressure. We studied 313 patients whom TDR were detected at their first test and who had a subsequent performed while ART-naive. The rate which became undetectable was estimated using exponential regression accounting for interval censoring. Most thymidine analogue (TAMs) T215 revertants (but not T215F/Y) found to be highly stable,...
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread through human populations worldwide, presenting across a spectrum of severity from asymptomatic carriage to failure and death.1Wu Z McGoogan JM Characteristics important lessons the disease 2019 (COVID-19) outbreak in China: summary report 72 314 cases Chinese Center for Disease Control Prevention.JAMA. 2020; 323: 1239-1242Crossref PubMed Scopus (12616) Google Scholar, 2Zhou F Yu T Du R et...
Emerging evidence suggests that activation of the complement system is critical in pathogenesis novel coronavirus, SARS-CoV-2, causative agent COVID-19-related lung injury. Inhibition terminal pathway by targeting protein 5 (C5) may be an effective therapeutic intervention CoV-mediated disease.1 Paroxysmal nocturnal haemoglobinuria (PNH) a rare, acquired haematopoietic stem cell (HSC) disease characterised intravascular haemolysis, increased thromboembolic risk and bone marrow failure.2 The...
ABSTRACT The laboratory diagnostic strategy used to determine the etiology of encephalitis in 203 patients is reported. An etiological diagnosis was made by first-line testing for 111 (55%) patients. Subsequent testing, based on individual case reviews, resulted 17 (8%) further diagnoses, which 12 (71%) were immune-mediated and 5 (29%) due infection. Seventy-five cases unknown etiology. Sixteen samples found be associated with either N -methyl- d -aspartate receptor or voltage-gated...
Highlights•We assessed the role of imaging in encephalitis.•We agreement between raters on scan interpretation.•Diagnosis for herpes simplex encephalitis (HSE) was good.•Agreement worse ADEM and other alternative aetiologies.•HSE can be dismissed if MRI normal 72 hours after neurological symptom onset (with negative CSF tests).AbstractAimTo assess early management findings a well-defined cohort suspected cases enrolled Prospective Aetiological Study Encephalitis conducted by Health...
There is a worldwide need for reagents to perform SARS-CoV-2 detection. Some laboratories have implemented kit-free protocols, but many others do not the capacity develop these and/or manual processing. We provide multiple workflows nucleic acid detection in clinical samples by comparing several commercially available RNA extraction methods: QIAamp Viral Mini Kit (QIAgen), RNAdvance Blood/Viral (Beckman) and Mag-Bind DNA/RNA 96 (Omega Bio-tek). also compared One-step RT-qPCR reagents: TaqMan...
Background. Infectious mononucleosis (IM) is a risk factor for chronic fatigue. Reduced activity the most consistent found to be associated with poor outcome following onset of infectious mononucleosis. However, little known about biological mechanisms involved in pathogenesis fatigue IM and no study, so far, has examined relation between certain illness beliefs outcome. This study explored immunological, endocrine, behavioural cognitive responses acute assessed which components these groups...
SUMMARY On 29 April 2009, an imported case of pandemic (H1N1) 2009 virus infection was detected in a London school. As further cases, pupils and staff members were identified, school closure mass prophylaxis implemented. An observational descriptive study conducted to provide insight into the clinical presentation transmission dynamics this setting. Between 15 May 91 symptomatic cases identified: 33 confirmed positive for infection; 57 tested negative; one results unavailable. Transmission...
Elective cesarean section decreases the likelihood of vertical human immunodeficiency virus (HIV) transmission from mother to infant. This study aimed determine whether done with spinal anesthesia on HIV-1-infected pregnant women taking antiretroviral therapy is associated intraoperative hemodynamic instability, postoperative complications, or changes in immune function HIV-1 viral load.A case-controlled was conducted over a 3-year period London academic hospital. Forty-four infected and...
Acute liver failure (ALF) in neonates is rare but carries a high mortality without transplantation. Herpes simplex virus (HSV) one of the microbes that more commonly causes ALF and potentially treatable; hence, early diagnosis treatment are important to avoid progression failure.We have analysed retrospectively case notes 11 patients with HSV-induced ALF. A history possible herpes infection was elicited 5 parents, HSV had not been suspected clinically. All were asymptomatic when discharged...
Our aim was to determine whether rhinovirus (RV) lower respiratory tract infections (LRTIs) in prematurely born infants increase health-related cost of care during infancy. 153 at <36 weeks gestation were prospectively followed 1 year. Cost calculated from the National Health Service reference costing scheme and healthcare utilisation determined by examining hospital/general practitioner records. 20 developed RV LRTIs (RV group), 17 syncytial virus (RSV) (RSV 12 both RSV (RV/RSV group) 74...