A5103068544- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Neonatal Health and Biochemistry
- HIV/AIDS Research and Interventions
- Neonatal and Maternal Infections
- Infectious Encephalopathies and Encephalitis
- Pneumocystis jirovecii pneumonia detection and treatment
- Parvovirus B19 Infection Studies
- Legionella and Acanthamoeba research
- Breastfeeding Practices and Influences
- HIV/AIDS drug development and treatment
- Syphilis Diagnosis and Treatment
- HIV Research and Treatment
- HIV-related health complications and treatments
- Adolescent Sexual and Reproductive Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis B Virus Studies
- HIV, TB, and STIs Epidemiology
- Ocular Diseases and Behçet’s Syndrome
Imperial College Healthcare NHS Trust
2014-2025
National Health Service
2024
St Mary's Hospital
2008-2024
St. Mary's Hospital
2006-2023
St. Mary’s Hospital
2004-2023
General University Hospital of Patras
2023
Gollwitzer-Meier-Klinik
2023
National and Kapodistrian University of Athens
2023
Research Institute Hospital 12 de Octubre
2023
St Mary's Hospital
2020
Highlights•We assessed the role of imaging in encephalitis.•We agreement between raters on scan interpretation.•Diagnosis for herpes simplex encephalitis (HSE) was good.•Agreement worse ADEM and other alternative aetiologies.•HSE can be dismissed if MRI normal 72 hours after neurological symptom onset (with negative CSF tests).AbstractAimTo assess early management findings a well-defined cohort suspected cases enrolled Prospective Aetiological Study Encephalitis conducted by Health...
A retrospective case-controlled study compared pregnancy outcomes between people with perinatally acquired HIV (PaHIV), horizontally (HaHIV), and those without HIV. PaHIV were more likely to be viraemic in early than HaHIV. When matched for age ethnicity, babies born premature, small gestational age, delivered by caesarean section require enhanced neonatal social care involvement infants age/ethnically HIV-uninfected individuals.
Invasive Group B streptococcus (GBS) is a major cause of serious neonatal infection. Current strategies to reduce early-onset GBS disease have no impact on late-onset (LOD). Although LOD viewed as sporadic event in the community, arising within intensive care unit (ICU) raises questions about mode acquisition.
The World Health Organisation advice for post-partum women living with HIV (WLHs) in low- and middle-income countries is to breastfeed on suppressive antiretroviral treatment use infant postnatal prophylaxis. In resource-rich settings, where formula feeding safe, avoidance of advised. A questionnaire was created survey attitudes breastfeeding WLHs the United Kingdom. This offered all eligible pregnant third trimester or within 3 months who attended outpatient clinics from 2017 2018....
Purpose of review HIV screening in pregnancy, universal suppressive antiretroviral therapy (ART) and breastfeeding avoidance can almost completely prevent vertical transmission HIV. Breastfeeding is associated with an additional risk transmission, although this extremely low maternal ART. This minimal must be balanced the benefits for women living (WLHIV) their infants. Guidance high-income countries has evolved, moving towards supported breast feeding on Recent findings Breastmilk accounts...
Children with perinatally acquired HIV (paHIV) remain at an increased risk of pneumococcal infection despite highly active antiretroviral therapy (HAART). Beyond infancy, responses to conjugate vaccine (PCV) under-investigated. There are currently no published data on serological response 13-valent PCV (PCV13) in the HIV-infected populations.We measured serotype-specific IgG 48 paHIV-infected child patients (CP), 27 young adult healthy controls (AHC) and 30 (CHC). Opsonophagocytic assay...
This updated national UK guideline offers recommendations on the management of genital herpes simplex virus (HSV) in mothers and pregnant people during pregnancy within 4 weeks following birth. It includes for first episode recurrent HSV, HSV preterm pre-labour rupture membranes co-infection with HIV. Recommendations around neonate are made, prevention postnatal transmission, breastfeeding, clinically discordant couples. is aimed at healthcare professionals working sexual health clinics,...
Congenital cytomegalovirus (cCMV) is the leading cause of neurodevelopmental and hearing impairment from in-utero infection. Late diagnosis results in limited treatment options may compromise long-term outcome.A retrospective audit infants with cCMV referred to a Tertiary Pediatric Infectious Diseases center 2012-2021. Data collected included timing diagnostics, initiation reasons for delays.90 confirmed were included, 46/90 (51%) symptomatic at birth. Most common diagnostics asymptomatic...
Objective: The aim of this study was to identify the prevalence emergent integrase drug resistance mutations (INSTI-DRMs) in international referrals a perinatal virtual clinic (PVC). Design: A retrospective cohort study. Setting: Monthly multidisciplinary PVC reviewing complex case management for children and adolescents with perinatally acquired HIV (CAWHIV). Participants: One hundred fourteen cases referred virological failure between October 2018 January 2024. Main outcome measures: Data...
To investigate the relationship between cell-associated HIV-1 dynamics and recent thymic T-cell emigrants, DNA receptor rearrangement excision circles (TREC, a marker of emigrants) were measured in peripheral blood mononuclear cells 181 samples from 33 HIV-1-infected children followed for 96 weeks after antiretroviral therapy (ART) initiation.At baseline, was higher with TREC (P=0.02) not related to age, CD4 or RNA multivariate analyses (P>0.3). Overall, increased decreased significantly ART...
Congenital cytomegalovirus (CCMV) accounts for high rates of infant morbidity and mortality. Neutropenia is a common finding in CCMV infection, which the age presentation overlaps with autoimmune neutropenia (AIN). AIN represents one most forms chronic childhood.A literature search exploring biologic associations between was conducted: PubMed (MEDLINE), Ovid Web Science. We further describe 2 cases concurrent AIN. Both were confirmed indirect granulocyte immunofluorescence test alternative...