A5070157327- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Antifungal resistance and susceptibility
- HIV/AIDS Research and Interventions
- Viral Infections and Vectors
- Inflammatory mediators and NSAID effects
- Heart Failure Treatment and Management
- Fungal Infections and Studies
- vaccines and immunoinformatics approaches
- Immunodeficiency and Autoimmune Disorders
- Antibiotic Resistance in Bacteria
- Neurological and metabolic disorders
- Electrolyte and hormonal disorders
- Bacterial Identification and Susceptibility Testing
- Epilepsy research and treatment
- Schizophrenia research and treatment
- Diet and metabolism studies
- Mosquito-borne diseases and control
- Blood disorders and treatments
- COVID-19 epidemiological studies
- HIV Research and Treatment
University College London
2019-2025
The Royal Free Hospital
2025
Public Health England
2019
University College London Hospitals NHS Foundation Trust
2019
University College Hospital
2019
Barts Health NHS Trust
2019
Imperial College London
2011-2012
University of Southampton
2009
INHALE investigated the impact of seeking pathogens by PCR on antibiotic stewardship and clinical outcomes in hospital-acquired ventilator-associated pneumonia (HAP VAP). This pragmatic multicentre, open-label RCT enrolled adults children with suspected HAP VAP at 14 ICUs. Patients were randomly allocated to standard care, or rapid in-ICU syndromic coupled optional prescribing guidance. Co-primary superiority 24 h non-inferiority cure days post-randomisation. Secondary included mortality,...
The prevalence of metabolic syndrome is increased 2-3-fold in people with serious mental illness (SMI). Monitoring physical health these individuals poor, despite clear guidance from the National Institute Health and Clinical Excellence. aim this study was to assess proportion SMI who had been screened for abnormalities within previous year a further undiagnosed not screened. notes computer records 100 patients community in-patient settings were evaluated. In subsequent study, assessed 71...
Rapid molecular diagnostic tests improve antimicrobial stewardship (AMS) by facilitating earlier refinement of therapy. The INHALE trial tested the application BioFire FilmArray Pneumonia Panel (Pneumonia Panel) for antibiotic prescribing hospital-acquired and ventilator-associated pneumonias (HAP/VAP) in UK intensive care units (ICUs). We report a behavioral study embedded within examining clinicians' perceptions using these tests. Semi-structured interviews were conducted with 20 ICU...
ABSTRACT Introduction Several viral respiratory infections - notably influenza are associated with secondary bacterial infection and additional pathology. The extent to which this applies for COVID-19 is unknown. Accordingly, we aimed define the bacteria causing pneumonias in ICU patients using FilmArray Pneumonia Panel, determine test’s potential management. Methods clinically-suspected at 5 UK hospitals were tested point of care. We collected patient demographic data compared results...
Abstract Background Hospital-acquired and ventilator-associated pneumonias (HAP VAP) are common in critical care can be life-threatening. Rapid microbiological diagnostics, linked to an algorithm translate their results into antibiotic choices, could simultaneously improve patient outcomes antimicrobial stewardship. Methods The INHALE Randomised Controlled Trial is a multi-centre, parallel study exploring the potential of BioFire FilmArray molecular diagnostic guide treatment HAP/VAP...
Abstract Background The FilmArray Pneumonia Panel (bioMérieux) is a rapid multiplex PCR aiming to increase speed and sensitivity in the microbiological diagnosis of pneumonia. This offers potential for improved antimicrobial stewardship evidence-based antibiotic prescribing. Whether such gains can be realised practise uncertain, thus, we conducted randomized controlled trial examine this. Methods Adults children ICU with suspected hospital-acquired or ventilator-associated pneumonia were...
A 42-year-old woman with a background of psoriatic arthritis presented 7-day medical history fevers unknown source; she had recently undergone elective shoulder arthroscopy, and her medications included anti-interleukin 17A (anti-IL-17A) drug, secukinumab. She went on to develop sepsis-induced cardiomyopathy, requiring veno-arterial extracorporeal membrane oxygenation (ECMO), from which was successfully weaned after 12 days. However, then candidaemia, new intra-abdominal collections found...