A5101956637- Animal Nutrition and Physiology
- Material Dynamics and Properties
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Birth, Development, and Health
- Electrostatics and Colloid Interactions
- HIV/AIDS Research and Interventions
- Phase Equilibria and Thermodynamics
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- X-ray Diffraction in Crystallography
- Spectroscopy and Quantum Chemical Studies
- Meat and Animal Product Quality
- Crystallization and Solubility Studies
- Animal Behavior and Welfare Studies
- Pickering emulsions and particle stabilization
- Analytical Chemistry and Chromatography
- Adipose Tissue and Metabolism
- Theoretical and Computational Physics
- Ruminant Nutrition and Digestive Physiology
- Nanopore and Nanochannel Transport Studies
- Pesticide and Herbicide Environmental Studies
- Petroleum Processing and Analysis
- Field-Flow Fractionation Techniques
- Inhalation and Respiratory Drug Delivery
UK Dementia Research Institute
2025
University of Surrey
2022-2024
University College London
2002-2023
University of Connecticut
2023
Institute for Bioengineering of Catalonia
2020-2023
Bristol Robotics Laboratory
2013-2022
University of Bristol
2014-2022
Southwestern University
2021
University of California, Santa Barbara
2018-2019
Santa Barbara City College
2019
Abstract Thirty-two piglets weaned at 28 days of age were used to test the hypothesis that maintenance nutrition after weaning would prevent normal decline in villous height and increase crypt depth hence preserve structure function small intestine. Piglets allocated one four treatments weaning: (1) control group killed weaning; (2) offered a dry starter diet ad libitum ; (3) ewes' fresh milk; (4) milk plus 20 g t-glutamine per I. every 2 h feeding schedule increased from 1·2 I piglet on 1st...
There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in absence selective pressure. We studied 313 patients whom TDR were detected at their first test and who had a subsequent performed while ART-naive. The rate which became undetectable was estimated using exponential regression accounting for interval censoring. Most thymidine analogue (TAMs) T215 revertants (but not T215F/Y) found to be highly stable,...
Surface-active asphaltene molecules are naturally found in crude oil, causing serious problems the petroleum industry by stabilizing emulsion drops, thus hindering separation of water and oil. Asphaltenes can adsorb at water–oil interfaces to form viscoelastic interfacial films that retard or prevent coalescence. Here, we measure evolving shear rheology as asphaltenes adsorb. Generally, stiffen with time, response crosses over from viscous-dominated elastic-dominated. However, significant...
In an externally imposed electrolyte (salt) concentration gradient, charged colloids drift at speeds of order one micrometre per second. This phenomenon is known as diffusiophoresis. systems with multiple salts and “crossed” salt gradients, a nonlocal component the electric field associated circulating (solenoidal) ion current can arise. in addition to conventional local that depends only on gradients. Here we report experimental observations verifying existence this contribution. To our...
Abstract Background People living with dementia often experience changes in independence and daily living, affecting their well-being quality of life. Behavioural correlate cognitive decline, functional impairment, caregiver distress, care availability. Methods We use data from a 3-year prospective observational study 141 people at home, using the Bristol Activities Daily Living Scale, Neuropsychiatric Inventory assessments, alongside self-reported healthcare-related data. Results Here we...
Sows that were either fat or lean at farrowing (340 280 g of body fat/kg BW, respectively) offered a low-protein (LP; 7.9% CP and 15.5 MJ DE/kg as fed) high-protein (HP; 19.0% 15.6 diet on an ad libitum basis throughout 4-wk lactation to test the hypothesis amount milk its composition are responsive supply endogenous (body reserves) exogenous (diet) substrates. Pigs weighed birth weekly during lactation, yield was estimated using deuterium oxide in early (d 4 8) late 24 28), samples...
Intracellular accumulation of the protease inhibitors (PIs) saquinavir (SQV), ritonavir (RTV), and indinavir (IDV) was determined in 50 human immunodeficiency virus-positive patients. Following extraction, PIs were quantified by mass spectrometry. Paired plasma intracellular samples collected over a full dosing interval from patients (13 on SQV, 6 RTV, 8 IDV, 16 SQV plus 7 IDV RTV) with viral load <400 copies/ml. Data expressed as intracellular/plasma drug concentration ratios. A hierarchy...
Significance Our bodies rely on molecular transport within a complex, nonequilibrium environment incorporating gradients of charged and neutral solutes. Concentration near solid surfaces are known to induce material via diffusioosmotic fluid flow. These well understood for molecules, but less so molecules such as glucose. Glucose is an important biological energy source often distributed in across cell membranes, vasculature, tissues, whole organs. We measure flow due glucose find its speed...
BackgroundSelection of protease mutations on antiretroviral therapy (ART) including a ritonavir-boosted inhibitor (PI) has been reported infrequently. Scarce data exist from long-term cohorts resistance incidence or mutational patterns emerging to different PIs.
One of the targets antiretroviral therapy is within cells infected with HIV. In order to improve therapeutic efficacy, it therefore important that intracellular pharmacokinetics drugs, such as nelfinavir mesylate and its active metabolite M8, are studied in addition plasma pharmacokinetics. Previously, accumulation protease inhibitors has been reported vivo, displaying following hierarchy: > saquinavir ritonavir indinavir. Multidrug resistance transporters, P-glycoprotein (P-gp), may result...
We investigated if feeding a high salt diet (pellet containing 14% NaCl) or saltbush (Atriplex nummularia) to ewes between day 60 of gestation and 21 lactation would allow their offspring gain more weight, produce wool, when grazing as adults compared from that were fed control (2% grazed pasture. At 10 months age, for 8 weeks then dry pasture 2 weeks. Throughout this time, liveweights, plasma renin activity wool growth (g/day) measured. Greasy clean fleece weights, characteristics measured...
A quasi two-dimensional colloidal suspension is studied under the influence of immobilisation (pinning) a random fraction its particles. We introduce novel experimental method to perform pinning and, with support numerical simulation, we find that increasing concentration smoothly arrests system, cross-over from regime high mobility and entropy low entropy. At local level, study fluctuations in area pins map them entropic structural signatures mobility, obtaining measure for system.
Asphaltenes are surface-active molecules that exist naturally in crude oil. They adsorb at the water–oil interface and form viscoelastic interfacial films stabilize emulsion droplets, making separation extremely challenging. There is, thus, a need for chemical demulsifiers to disrupt asphaltene films, and, thereby, facilitate separation. Here, we examine ethylcellulose (EC) as model demulsifier measure its impact on properties of using shear microrheology. When EC is mixed with an oil...
If ewes consumed a high-salt diet or saltbush during the last 3 months of pregnancy and for weeks after birth, we expected renin activity their lamb to be suppressed at birth age. We also an increase in concentration cations other than sodium ewe's milk plasma Na birth. To test these hypotheses, Merino were fed (14% NaCl) animal house compared control eating (2% NaCl). In addition, grazing (about 13% salt diet) pasture from day 60 Lambs born consuming had 85% lower (P < 0.001) offspring...
SUMMARY A rotavirus isolated from a field outbreak of diarrhoea in artificially reared piglets was purified, filtered and administered orally to gnotobiotic conventional piglets. Four successive passages the virus produced severe within 20 24 hours administration. The lasted several days causing dehydration, emaciation, loss body weight some deaths. Virus demonstrated faeces infected by electron microscopy. Conventionally developed little or no when given virus, whereas moderate which 3 8...
Impurities in crystalline materials introduce disorder into an otherwise ordered structure due to the formation of lattice defects and grain boundaries. The properties resulting polycrystal can differ remarkably from those ideal single crystal. Here we investigate a quasi-two-dimensional system colloidal spheres containing small fraction aspherical impurities characterise polycrystalline monolayer. We find that, vicinity impurity, underlying hexagonal is deformed preference for five-fold...
We established an experimental model to study nitrogen (N) partitioning in lactating primiparous sows alimented three levels of nutrient intake. Thirty-six fitted with a gastric cannula and fed 15.4 MJ DE/kg 18.6% CP diet were allocated one treatments after farrowing: 1) ad libitum-fed; 2) restricted-fed 55% the libitum feed intake; 3) superalimented at least 125% These intakes successfully achieved throughout lactation. Nitrogen balance was studied for 5-d periods starting on d 2, 11, 19...
Phospholipids are found throughout the natural world, including lung surfactant (LS) layer that reduces pulmonary surface tension and enables breathing. Fibrinogen, a protein involved in blood clotting process, is implicated LS inactivation progression of disorders such as acute respiratory distress syndrome. However, interaction between fibrinogen at air-water interface poorly understood. Through combined microrheological, confocal epifluorescence microscopy approach we quantify interfacial...
Background Adolescence is a critical time for adopting health behaviors which continue through adulthood. There lack of data regarding perspectives US adolescents and young adults on their dental oral hygiene practice. Methods Adolescents adults, age 14–24, from MyVoice, nationwide text message poll youth. were asked five open-ended questions the importance impact COVID-19 pandemic. Responses qualitatively analyzed using thematic analysis. Chi-square test was used to examine differences in...