A5017596402- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Analog and Mixed-Signal Circuit Design
- Wireless Body Area Networks
- Photoreceptor and optogenetics research
- CCD and CMOS Imaging Sensors
- Wireless Power Transfer Systems
- Analytical Chemistry and Sensors
- Non-Invasive Vital Sign Monitoring
- Semiconductor materials and devices
- Muscle activation and electromyography studies
- Ferroelectric and Negative Capacitance Devices
- Microwave Imaging and Scattering Analysis
- Industrial Vision Systems and Defect Detection
- Energy Harvesting in Wireless Networks
- Blind Source Separation Techniques
- ECG Monitoring and Analysis
- Sleep and Wakefulness Research
- Neurological disorders and treatments
- Advanced MEMS and NEMS Technologies
- Advancements in PLL and VCO Technologies
- Electrical and Bioimpedance Tomography
- Neural Networks and Applications
Imperial College London
2016-2025
UK Dementia Research Institute
2020-2025
NIHR Imperial Biomedical Research Centre
2009-2023
Inspire
2015-2023
University of Surrey
2021-2023
Bandung Institute of Technology
2020-2022
University College London
2019-2021
Imperial Valley College
2021
University of Bologna
2020
Shanghai Jiao Tong University
2020
It has been suggested that the function of sleep is to actively clear metabolites and toxins from brain. Enhanced clearance also said occur during anesthesia. Here, we measure movement fluorescent molecules in brains male mice show is, fact, independent wake or Moreover, brain markedly reduced, not increased,
This paper describes a platform to achieve targeted drug delivery in the next-generation wireless capsule endoscopy. The consists of two highly novel subsystems: one is micropositioning mechanism which can deliver 1 ml medication and other holding mechanism, gives functionality resisting peristalsis. allows needle be positioned within 22.5 ° segment cylindrical extendible by up 1.5 mm outside body. achieves both these functions using only single micromotor occupying total volume just 200...
The prefrontal cortex (PFC) enables mammals to respond situations, including internal states, with appropriate actions. One such state could be 'tiredness'. Here, using activity tagging in the mouse PFC, we identified particularly excitable, fast-spiking, somatostatin-expressing, γ-aminobutyric acid (GABA) (PFC
Abstract Silicon integrated circuits (ICs) are central to the next-generation miniature active neural implants, whether packaged in soft polymers for flexible bioelectronics or implanted as bare die probes. These emerging applications bring IC closer corrosive body environment, raising reliability concerns, particularly chronic use. Here, we evaluate inherent hermeticity of ICs, and examine potential polydimethylsiloxane (PDMS), a moisture-permeable elastomer, standalone encapsulation...
This paper presents an 8 channel energy-efficient neural stimulator for generating charge-balanced asymmetric pulses. Power consumption is reduced by implementing a fully-integrated DC-DC converter that uses reconfigurable switched capacitor topology to provide 4 output voltages Dynamic Voltage Scaling (DVS). DC conversion efficiencies of up 82% are achieved using integrated capacitances under 1 nF and the DVS approach offers power savings 50% compared front end typical current controlled...
Objective. Brain-machine interfaces (BMIs) seek to restore lost motor functions in individuals with neurological disorders by enabling them control external devices directly their thoughts. This work aims improve robustness and decoding accuracy that currently become major challenges the clinical translation of intracortical BMIs.Approach. We propose entire spiking activity (ESA)-an envelope can be extracted a simple, threshold-less, automated technique-as input signal. couple ESA deep...
There is growing interest in using adaptive neuromodulation to provide a more personalized therapy experience that might improve patient outcomes. Current implant technology, however, can be limited its algorithm capability. To enable exploration of algorithms with chronic implants, we designed and validated the 'Picostim DyNeuMo Mk-1' (DyNeuMo Mk-1 for short), fully-implantable, research stimulator titrates stimulation based on circadian rhythms (e.g. sleep, wake) patient's movement state...
This paper describes a novel partial-current-steering stimulation circuit for implantable vestibular prostheses. The drive hardware momentarily delivers charge-balanced asymmetric stimulus to dummy load before steering towards the electrodes. In this fashion, power is conserved while still gaining from benefits of current steering. has been designed be digitally programmable as part an prosthesis. implemented in AMS 0.35 mum 2P4M CMOS technology.
This paper presents an extended model for the CMOS-based ion-sensitive field-effect transistor, incorporating design parameters associated with physical geometry of device. can, first time, provide a good match between calculated and measured characteristics by taking into account effects nonidealities such as threshold voltage variation sensor noise. The is evaluated through number devices varying (chemical sensing area MOSFET dimensions) fabricated in commercially available 0.35-μm CMOS...
Longitudinal observation of single unit neural activity from large numbers cortical neurons in awake and mobile animals is often a vital step studying network behaviour towards the prospect building effective brain-machine interfaces (BMIs). These recordings generate enormous amounts data for transmission storage, typically require offline processing to tease out individual neurons. Our aim was create compact system capable of: (1) reducing bandwidth by circa 2 3 orders magnitude (greatly...
Modern microtechnology is enabling the channel count of neural recording integrated circuits to scale exponentially. However, raw data bandwidth these systems increasing proportionately, presenting major challenges in terms power consumption and transmission (especially for wireless systems). This paper presents a system that exploits sparse nature signals address provides reconfigurable low-bandwidth event-driven output. Specifically, we present novel 64-channel low-noise (2.1 μV <sub...
We present a platform technology encompassing family of innovations that together aim to tackle key challenges with existing implantable brain machine interfaces. The ENGINI (Empowering Next Generation Implantable Neural Interfaces) utilizes 3-tier network (external processor, cranial transponder, intracortical probes) inductively couple power to, and communicate data from, distributed array freely-floating mm-scale probes. Novel features integrated into each probe include: (1) an niobium...
Neuromodulation technologies are progressing from pacemaking and sensory operations to full closed-loop control. In particular, optogenetics-the genetic modification of light sensitivity into neural tissue allows for simultaneous optical stimulation electronic recording. This paper presents a interface application-specified integrated circuit (ASIC) intelligent optoelectronic probes. The architecture is designed enable It provides four low noise (2.08 μV <sub...
Next generation implantable neural interfaces are targeting devices with mm-scale form factors that freely floating and completely wireless. Scalability to more recording (or stimulation) channels will be achieved through distributing multiple devices, instead of the current approach uses a single centralized implant wired individual electrodes or arrays. In this way, challenges associated tethers, micromotion, reliability wiring is mitigated. This concept now being applied both central...
Deep brain stimulation (DBS) for Parkinson's disease, essential tremor and epilepsy is an established palliative treatment. DBS uses electrical neuromodulation to suppress symptoms. Most current systems provide a continuous pattern of fixed stimulation, with clinical follow-ups refine settings constrained normal office hours. An issue this management strategy that the impact on circadian, i.e. sleep-wake, rhythms not fully considered; either in device design or follow-up. Since devices can...
Objective: In recent years, radar technology has been extensively utilized in contactless human behavior monitoring systems. The unique capabilities of ultra-wideband (UWB) radars compared to conventional technologies, due time-of-flight measurements, present new untapped opportunities for in-depth movement during overground locomotion. This study aims investigate the deployability UWB accurately capturing gait patterns healthy individuals with no known walking impairments. Methods: A novel...
Abstract Background People living with dementia often experience changes in independence and daily living, affecting their well-being quality of life. Behavioural correlate cognitive decline, functional impairment, caregiver distress, care availability. Methods We use data from a 3-year prospective observational study 141 people at home, using the Bristol Activities Daily Living Scale, Neuropsychiatric Inventory assessments, alongside self-reported healthcare-related data. Results Here we...
Ultra-wideband (UWB) radar technology has emerged as a promising alternative for creating portable and cost-effective in-home monitoring devices. Although there exists good evidence supporting its effectiveness in sleep monitoring, previous studies predominantly focus on younger, healthy participants. This research evaluates the applicability of commercial impulse UWB older people with neurodegenerative disorders (NDDs). 47 (mean age: 71.2 6.5, 18 prodromal or mild Alzheimer's disease)...