A5002524050- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- EEG and Brain-Computer Interfaces
- Craniofacial Disorders and Treatments
- Bone fractures and treatments
- Semiconductor materials and devices
- Connective tissue disorders research
- Neuroscience and Neuropharmacology Research
- Muscle activation and electromyography studies
- Conducting polymers and applications
- Hearing Loss and Rehabilitation
- Sleep and Wakefulness Research
- Electrochemical Analysis and Applications
- Advanced Sensor and Energy Harvesting Materials
- Photoreceptor and optogenetics research
- Anatomy and Medical Technology
- Hearing, Cochlea, Tinnitus, Genetics
- Vehicle License Plate Recognition
Institute of Cognitive Neuroscience and Psychology
2016-2025
HUN-REN Research Centre for Natural Sciences
2016-2025
Pázmány Péter Catholic University
2016-2025
Semmelweis University
2016-2018
Hungarian Academy of Sciences
2011-2018
Ludwig-Maximilians-Universität München
2010-2011
Abstract Silicon integrated circuits (ICs) are central to the next-generation miniature active neural implants, whether packaged in soft polymers for flexible bioelectronics or implanted as bare die probes. These emerging applications bring IC closer corrosive body environment, raising reliability concerns, particularly chronic use. Here, we evaluate inherent hermeticity of ICs, and examine potential polydimethylsiloxane (PDMS), a moisture-permeable elastomer, standalone encapsulation...
Abstract Rhythmic slow waves characterize brain electrical activity during natural deep sleep and under anesthesia, reflecting the synchronous membrane potential fluctuations of neurons in thalamocortical network. Strong evidence indicates that neocortex plays an important role generation wave ( SWA ), however, contributions individual cortical layers to are still unclear. The anatomically correct laminar profiles were revealed ketamine/xylazine with combined local field recordings,...
Recording simultaneous activity of a large number neurons in distributed neuronal networks is crucial to understand higher order brain functions. We demonstrate the vivo performance recently developed electrophysiological recording system comprising two-dimensional, multi-shank, high-density silicon probe with integrated complementary metal-oxide semiconductor electronics. The implements concept electronic depth control (EDC), which enables selection limited sites on each shafts. This...
Abstract Miniaturization of next‐generation active neural implants requires novel micro‐packaging solutions that can maintain their long‐term coating performance in the body. This work presents two thin‐film coatings and evaluates biostability vivo over a 7‐month animal study. To evaluate on representative surfaces, silicon microchips with different surface microtopography are used. Microchips coated either ≈100 nm thick inorganic hafnium‐based multilayer deposited via atomic layer...
Stereo-electroencephalography depth electrodes, regularly implanted into drug-resistant patients with focal epilepsy to localize the epileptic focus, have a low channel count (6-12 macro- or microelectrodes), limited spatial resolution (0.5-1 cm) and large contact area of recording sites (~mm2). Thus, they are not suited for high-density local field potential multiunit recordings. In this paper, we evaluated long-term electrophysiological performance histocompatibility neural interface...
Abstract It is an uninformative truism to state that the brain operates at multiple spatial and temporal scales, each with own set of emergent phenomena. More worthy attention point our current understanding it cannot clearly indicate which these phenomenological scales are significant contributors brain’s function primary output (i.e. behaviour). Apart from sheer complexity problem, a major contributing factor this affairs lack instrumentation can simultaneously address without causing...
Abstract In this article, we evaluated the electrophysiological performance of a novel, high-complexity silicon probe array. This brain-implantable implements dynamically reconfigurable voltage-recording device, coordinating large numbers electronically switchable recording sites, referred to as electronic depth control (EDC). Our results show potential EDC devices record good-quality local field potentials, and single- multiple-unit activities in cortical regions during pharmacologically...
We examined how changes in intensity and interaural time difference (ITD) influenced the coding of low-frequency sounds inferior colliculus male gerbils at both single neuron population levels. found that along positive slope rate-level function (RLF) evoked spectrotemporal filtering overall timing spike events but preserved their precision across trials such decoding responses was not affected. In contrast, ITD did trigger filtering, have strong effects on and, consequently, decoder...
A novel silicon-based microelectrode array with one- and two-dimensional variants was developed in the framework of EU-funded research project NeuroProbes. The electrode comprises complementary-metal-oxide-semiconductor based integrated circuitry to implement concept electronic depth control which is used select up 32 recording sites from more than 1000 possible channels on four slender probe shafts. tested acute experiments performed simultaneously cortex thalamus rat brain. In both brain...
Abstract Silicon integrated circuits (ICs) are central to the next-generation miniature active neural implants, whether packaged in soft polymers for flexible bioelectronics or implanted as bare die probes. These emerging applications bring IC closer corrosive body environment, raising reliability concerns, particularly long-term clinical use. Here, we evaluated electrical and material stability of silicon-ICs from two foundries, after one-year accelerated vitro vivo animal studies. The ICs...
In this paper, we investigate the long-term adhesion strength and barrier property of our recently proposed encapsulation stack that includes PDMS-Parylene C PECVD interlayers (SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> SiC) for improvement. To evaluate stack, sample preparation consisted in depositing approximately 25 nm SiC SiO on half wafers, previously coated with Parylene C. Next, $50 \mu \mathrm{m}$ PDMS was spin-coated...