A5061115967- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Vagus Nerve Stimulation Research
- Neuroscience and Neural Engineering
- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Amyotrophic Lateral Sclerosis Research
- Spinal Cord Injury Research
- Motor Control and Adaptation
- Photoreceptor and optogenetics research
- Cardiovascular Syncope and Autonomic Disorders
- Optical Imaging and Spectroscopy Techniques
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Memory and Neural Mechanisms
- Molecular Communication and Nanonetworks
- Sleep and Wakefulness Research
- Parkinson's Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Vestibular and auditory disorders
- Genetic Neurodegenerative Diseases
- Neuroscience and Music Perception
Aston University
2020-2025
Newcastle University
2012-2022
City College of New York
2016
Northwestern University
2011-2013
Royal Victoria Infirmary
2012
Université de Picardie Jules Verne
2010
CEA Gramat
2005
Damage to the corticospinal tract is a leading cause of motor disability, for example in stroke or spinal cord injury. Some function usually recovers, but whether plasticity undamaged ipsilaterally descending axons and/or brainstem pathways such as reticulospinal contributes recovery unknown. Here, we examined connectivity these neurons after from lesions. Extensive unilateral lesions medullary fibres pyramidal were made three adult macaque monkeys. After an initial contralateral flaccid...
In motor neuron disease, the focus of therapy is to prevent or slow neuronal degeneration with neuroprotective pharmacological agents; early diagnosis and treatment are thus essential. Incorporation needle electromyographic evidence lower into diagnostic criteria has undoubtedly advanced diagnosis, but even earlier might be possible by including tests subclinical upper disease. We hypothesized that beta-band (15–30 Hz) intermuscular coherence could used as an electrophysiological marker...
Injury to the mature motor system drives significant spontaneous axonal sprouting instead of axon regeneration. Knowing circuit-level determinants is important for repairing circuits after injury achieve functional rehabilitation. Competitive interactions are known shape corticospinal tract outgrowth and withdrawal during development. Whether how competition contributes reorganization spinal unclear. To study this question, we examined plastic changes in axons response two complementary...
Absence epilepsy is characterized by 3-Hz generalized spike-and-wave discharges (GSWD) on the electroencephalogram, associated with behavioral arrest. It may be severe, and even in childhood benign absence cognitive delay frequent, yet metabolic/hemodynamic aspects of this kind have not been established. We aimed to determine if GSWD were related hemodynamic changes using a new technique high temporal resolution: near infrared spectroscopy (NIRS).NIRS gaining acceptance as particularly...
Transcranial magnetic stimulation (TMS) of cerebral cortex is a popular technique for the non-invasive investigation motor function. TMS often assumed to influence spinal circuits solely via corticospinal tract. We were interested in possible trans-synaptic effects cortical on ponto-medullary reticular formation brainstem, which source reticulospinal tract and could also generate output. recorded from 210 single units three anaesthetized macaque monkeys whilst was performed over primary...
A major issue to be addressed in the development of neural interfaces for prosthetic control is need somatosensory feedback.Here, we investigate two possible strategies: electrical stimulation either dorsal root ganglia (DRG) or primary cortex (S1).In each approach, must determine a model that reflects representation limb state terms discharge.This can then used design stimuli artificially activate nervous system convey information about subject.Electrically activating DRG neurons using...
Early evolution of the motor cortex included development connections to brainstem reticulospinal neurons; these projections persist in primates. In this study, we examined organization corticoreticular five macaque monkeys (one male) using both intracellular and extracellular recordings from reticular formation neurons, including identified cells. Synaptic responses stimulation different parts primary (M1) supplementary area (SMA) bilaterally were assessed. Widespread short latency...
Coordinated movement requires patterned activation of muscles. In this study, we examined differences in selective primate upper limb muscles by cortical and subcortical regions. Five macaque monkeys were trained to perform a reach grasp task, electromyogram (EMG) was recorded from 10 24 while weak single-pulse stimuli delivered through microelectrodes inserted the motor cortex (M1), reticular formation (RF), or cervical spinal cord (SC). Stimulus intensity adjusted level just above...
Brain machine interfaces (BMIs) that decode control signals from motor cortex have developed tremendously in the past decade, but virtually all rely exclusively on vision to provide feedback.There is now increasing interest developing an afferent interface replace natural somatosensation, much as cochlear implant has done for sense of hearing.Preliminary experiments toward a somatosensory neuroprosthesis mostly addressed touch, proprioception, limb position and movement, also critical...
Paired Associative Stimulation (PAS) has shown promise in promoting motor cortex plasticity by using transcranial magnetic stimulation (TMS) paired with peripheral nerve stimulation. However, the effectiveness of PAS is often limited its short-lived potentiation effects. Recent research indicates that respiratory rhythms can influence cortical excitability, suggesting a potential method to enhance efficacy. This study investigated impact synchronizing phase transitions - specifically,...
The reticulospinal tract (RST) plays a pivotal role in motor control, especially during recovery after neurological injuries such as stroke and spinal cord injury (SCI). Understanding how RST activity is modulated offers valuable insights into improving function recovery. Recent studies have demonstrated that breathing rhythms influence brain activity. This study explores respiratory modulate excitability tasks, using the StartReact paradigm to examine reaction times (RTs) across visual...
The reticular formation is important in primate motor control, both health and during recovery after brain damage. Little known about the different neurons present nuclei. Here we recorded extracellular spikes from five healthy female awake behaving monkeys (193 cells), two 1 year a unilateral pyramidal tract lesion (125 cells). Analysis of spike shape four measures derived interspike interval distribution identified clusters control animals. Cluster cells had slow firing rate. 2 narrow...
Absence epilepsy may be severe and is frequently accompanied by cognitive delay, yet its metabolic/hemodynamic aspects have not been established. The Genetic Epilepsy Rats from Strasbourg (GAERS) are an isomorphic, predictive, homologous model of human absence epilepsy. We studied hemodynamic changes related to generalized spike-and-wave discharges (GSWDs) in GAERS using a technique with high temporal resolution: near-infrared spectroscopy (NIRS). hypothesized that conflicting results other...
This study analyzed the direct short-term effect of vagus nerve stimulation (VNS) on respiratory sinus arrhythmia (RSA) in children with pharmacoresistant epilepsy.RSA magnitude is calculated as ratio between maximum and minimum heart rate for each cycle-before, during, after actual VNS period. In 10 children, changes RSA were evaluated polysomnographic recordings, including electrocardiography (ECG), electroencephalography (EEG), thoracoabdominal distension, nasal airflow, artifacts....
Summary: Purpose: To analyze respiratory alterations and effects on SaO 2 caused by vagus nerve stimulation (VNS) in children with epilepsy. Methods: Polysomnographic recordings, including electroencephalography, thoracoabdominal distention, nasal airflow, , VNS artifact were evaluated 10 pharmacoresistant epilepsy treated VNS. Results: Each a significant increase frequency (p < 0.05) throughout the period decrease thoracoabdominal‐distention amplitude 0.05), especially at beginning of...
Summary: Purpose : This study analyzed changes in the heart rates of children receiving vagus nerve stimulation (VNS) therapy for pharmacoresistant epilepsy. Methods Changes ten VNS epilepsy were evaluated with polysomnographic recordings, including electrocardiogram (ECG), EEG, thoraco‐abdominal distension, nasal airflow, and artifacts. Measurements during compared those at baseline each patient. Result While pulse generator was delivering stimulation, four increased significantly (p <...
Changes in sleep behavior and sleep-related cortical activity have been reported conditions associated with abnormal alpha-synuclein (α-syn) expression, particular Parkinson's disease (PD) dementia Lewy bodies (DLB). Notably, changes can occur patients years before the onset of cognitive decline. Sleep-related network oscillations play a key role memory function, but how α-syn impacts generation such is currently unclear. To determine whether early could also be observed, prior to any...
Abstract Electrical neurostimulation is effective in treating neurological disorders, but associated recording artefacts generally limit applications to ‘open-loop’ stimuli. Since light does not prevent concurrent electrical recordings, optogenetics enables real-time, continuous ‘closed-loop’ control of brain activity. Here we show that closed-loop optogenetic stimulation with excitatory opsins (CLOSe) affords precise manipulation neural dynamics, both vitro , slices from transgenic mice,...
Abstract Objective We are developing a new closed-loop brain stimulation method by embedding, within music, auditory elements that respond to the listener’s activity. Here we show this brain-responsive music has systematic and targeted effects on neural oscillations implicated in variety of neurological mental health disorders. Approach recorded magnetoencephalogram (MEG) or electroencephalogram (EEG) signals from participants as they listened synthesized commercial audio software. Brain...