A5087543045- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
Bioinduction (United Kingdom)
2014-2023
University of Antwerp
2020
Antwerp University Hospital
2020
There is growing interest in using adaptive neuromodulation to provide a more personalized therapy experience that might improve patient outcomes. Current implant technology, however, can be limited its algorithm capability. To enable exploration of algorithms with chronic implants, we designed and validated the 'Picostim DyNeuMo Mk-1' (DyNeuMo Mk-1 for short), fully-implantable, research stimulator titrates stimulation based on circadian rhythms (e.g. sleep, wake) patient's movement state...
Deep brain stimulation (DBS) for Parkinson's disease, essential tremor and epilepsy is an established palliative treatment. DBS uses electrical neuromodulation to suppress symptoms. Most current systems provide a continuous pattern of fixed stimulation, with clinical follow-ups refine settings constrained normal office hours. An issue this management strategy that the impact on circadian, i.e. sleep-wake, rhythms not fully considered; either in device design or follow-up. Since devices can...
Abstract There is growing interest in using adaptive neuro-modulation to provide a more personalized therapy experience that might improve patient outcomes. Current implant technology, however, can be limited its algorithm capability. To enable exploration of algorithms with chronic implants, we designed and validated the ‘Picostim DyNeuMo Mk-1’ (DyNeuMo Mk-1 for short), fully-implantable, research stimulator titrates stimulation based on circadian rhythms (e.g. sleep, wake) patient’s...
Providing clinicians with objective outcomes of neuromodulation therapy is a key unmet need, especially in emerging areas such as epilepsy and mood disorders. These diseases have episodic behavior circadian/multidien rhythm characteristics that are difficult to capture short clinical follow-ups. This work presents preliminary validation evidence for an implantable system integrated physiological event monitoring, initial focus on seizure tracking epilepsy. The was developed address currently...