A5018543674- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Sleep and Wakefulness Research
- Parkinson's Disease Mechanisms and Treatments
- Vagus Nerve Stimulation Research
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Photoreceptor and optogenetics research
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Mathematical Biology Tumor Growth
- Neonatal and fetal brain pathology
- Abdominal Trauma and Injuries
- Spaceflight effects on biology
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- CCD and CMOS Imaging Sensors
- Psychosomatic Disorders and Their Treatments
- Gallbladder and Bile Duct Disorders
- Traumatic Brain Injury Research
- Pharmacological Effects and Toxicity Studies
- Computational Drug Discovery Methods
- Network Time Synchronization Technologies
University of Oxford
2019-2024
Medical Research Council
2024
St George's, University of London
2024
City St George's, University of London
2024
MRC Brain Network Dynamics Unit
2024
Nuffield Orthopaedic Centre
2019-2024
John Radcliffe Hospital
2016-2023
Oxford University Hospitals NHS Trust
2021
Deep brain stimulation (DBS) for Parkinson's disease, essential tremor and epilepsy is an established palliative treatment. DBS uses electrical neuromodulation to suppress symptoms. Most current systems provide a continuous pattern of fixed stimulation, with clinical follow-ups refine settings constrained normal office hours. An issue this management strategy that the impact on circadian, i.e. sleep-wake, rhythms not fully considered; either in device design or follow-up. Since devices can...
Abstract Background Tremor phase-locked deep brain stimulation (DBS) has been shown to modulate symptom severity in patients with postural tremor, including essential (ET) and dystonic tremor (DT). This, provides a potential alternative therapy that targets the underlying pathological oscillations less energy delivered than existing systems. Previous DBS studies focused on evaluating effect of unilateral tremor-dominant hand. Considering usually presents bilaterally, it remains unknown how...
The pedunculopontine nucleus (PPN) is a reticular collection of neurons at the junction midbrain and pons, playing an important role in modulating posture locomotion. Deep brain stimulation PPN has been proposed as emerging treatment for patients with Parkinson's disease (PD) or multiple system atrophy (MSA) who have gait-related atypical parkinsonian syndromes. In this study, we investigated activities during gait to better understand its functional Specifically, whether activity...
Abstract Brainstem nuclei, such as the pedunculopontine nucleus, send activating projections to cortex, modulating states of sleep, wakefulness and arousal levels. Surgical modulation subcortical activity using deep brain stimulation (DBS) is utilised in management pain movement disorders. DBS brainstem circuits a state-dependent manner could offer an attractive alternative severe pharmacoresistant cases hypersomnia disorders consciousness, where behavioural activation desired. We wanted...
Essential tremor (ET) is one of the most common movement disorders in adults. Deep brain stimulation (DBS) ventralis intermediate nucleus (VIM) thalamus and/or posterior subthalamic area (PSA) has been shown to provide significant suppression patients with ET, but inter-patient variability and habituation stimulation. Several non-invasive neuromodulation techniques targeting other parts central nervous system, including cerebellar, motor cortex, or peripheral nerves, have also developed for...
Application of closed-loop approaches in systems neuroscience and brain-computer interfaces holds great promise for revolutionizing our understanding the brain developing novel neuromodulation strategies to restore lost function. The anterior forebrain mesocircuit (AFM) mammalian is hypothesized underlie arousal regulation cortex striatum, support cognitive functions during wakefulness. Dysfunction contribute dysfunctions various neurological disorders, most prominently patients following...
The dorsal anterior cingulate cortex (dACC) is a key node in the human salience network. It has been ascribed motor, pain-processing and affective functions. However, dynamics of information flow this complex region how it responds to inputs remain unclear are difficult study using non-invasive electrophysiology. area targeted by neurosurgery treat neuropathic pain. During deep brain stimulation surgery, we recorded local field potentials from humans during decision-making task requiring...
Abstract Existing neurostimulation systems implanted for the treatment of neurodegenerative disorders generally deliver invariable therapy parameters, regardless phase sleep/wake cycle. However, there is considerable evidence that brain activity in these conditions varies according to this cycle, with discrete patterns dysfunction linked loss circadian rhythmicity, worse clinical outcomes and impaired patient quality life. We present a targeted concept neuromodulation using novel device...
Existing neurostimulation systems implanted for the treatment of neurodegenerative disorders generally deliver invariable therapy parameters, regardless phase sleep/wake cycle. However, there is considerable evidence that brain activity in these conditions varies according to this cycle, with discrete patterns dysfunction linked loss circadian rhythmicity, worse clinical outcomes and impaired patient quality life. We present a targeted concept neuromodulation using novel device platform....
Abstract Disorders of Consciousness (DoC) result in profound functional impairment, adversely affecting the lives a predominantly younger patient population. Currently, effective treatment options for those who have reached chronicity (prolonged symptom duration over 4 weeks) are extremely limited, with majority such cases facing life-long dependence on carers and poor quality life. Here we briefly review current evidence caseload, diagnostic management United Kingdom (UK), States America...
The interaction of glioblastoma (GB) and microglia is critical due to its implications for tumor progression, immune response modulation, potential therapeutic strategies. However, the role in GB pathogenesis remains unclear, especially regarding vivo dynamics their interplay. Performing three-photon imaging an autochthonous, immunocompetent mouse model, we examined tumor/microglia within previously inaccessible regions at far infiltration zone corpus callosum. Initially, increased tissue...
Abstract Essential tremor (ET) is one of the most common movement disorders in adults. Deep brain stimulation (DBS) ventralis intermediate nucleus (VIM) thalamus and/or posterior subthalamic area (PSA) has been shown to provide significant suppression patients with ET, but inter-patient variability and habituation stimulation. Several non-invasive neuromodulation techniques targeting other parts central nervous system, including cerebellar, motor cortex, or peripheral nerves, have also...
Abstract Backgroud The pedunculopontine nucleus (PPN) is a reticular collection of neurons at the junction midbrain and pons, playing an important role in modulating posture locomotion. Deep brain stimulation PPN has been proposed as emerging treatment for patients with Parkinson’s disease (PD) or multiple system atrophy (MSA) suffering gait-related atypical parkinsonian syndromes. Objective In this study, we investigated activities during gait to better understand its functional...
Abstract Surgical neuromodulation through implantable devices allows for stimulation delivery to subcortical regions, crucial symptom control in many debilitating neurological conditions. Novel closed-loop algorithms deliver therapy tailor-made endogenous physiological activity, however rely on precise sensing of signals such as oscillations. The frequency intrinsic activity can vary depending target nucleus, while factors regional anatomy may also contribute variability signals. While...
Surgical neuromodulation through implantable devices allows for stimulation delivery to subcortical regions, crucial symptom control in many debilitating neurological conditions. Novel closed-loop algorithms deliver therapy tailor-made endogenous physiological activity, however rely on precise sensing of signals such as oscillations. The frequency intrinsic activity can vary depending target nucleus, while factors regional anatomy may also contribute variability signals. While artefact...