A5059180585- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Nasal Surgery and Airway Studies
- Olfactory and Sensory Function Studies
- Neuroscience of respiration and sleep
- Sinusitis and nasal conditions
- Respiratory and Cough-Related Research
- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Contact Dermatitis and Allergies
- Biochemical Analysis and Sensing Techniques
- Food Allergy and Anaphylaxis Research
- Dysphagia Assessment and Management
- Dermatology and Skin Diseases
- Mycobacterium research and diagnosis
- Otitis Media and Relapsing Polychondritis
- Advanced Chemical Sensor Technologies
- Cardiovascular and Diving-Related Complications
- Voice and Speech Disorders
- Infectious Diseases and Mycology
- Drug-Induced Adverse Reactions
- Congenital Ear and Nasal Anomalies
- Tumors and Oncological Cases
- Hydrogen's biological and therapeutic effects
Siriraj Hospital
2008-2023
Mahidol University
2009-2023
Bangkok Hospital
2006
University of Chicago
2000-2004
Pythiosis is an emerging and life-threatening infectious disease in humans animals that caused by the pathogenic oomycete Pythium insidiosum. Human pythiosis found mostly Thailand, although has been increasingly reported worldwide. Clinical information on human limited, health care professionals are unfamiliar with disease, leading to underdiagnosis, delayed treatment, poor prognosis.To retrospectively study clinical epidemiological features of pythiosis, we analyzed data from patients...
Objective: To evaluate regional taste function in normal Thai subjects using standard suprathreshold tastants. Materials and Methods: A total of 93 healthy (41 males 52 females), aged 20 to 60 years, were recruited. Regional was assessed four tastants, with both identification scores VAS recorded. Results: The mean score 10.7 on the right side 10.8 left side, no statistically significant differences between sides across all subgroups. highest for sweet tastants posterior tongue as tested...
Data from in vitro, vivo, and ex vivo studies suggest that second-generation antihistamines have a number of antiallergic, anti-inflammatory properties appear to be independent their H1-blockade activity. First-generation also properties, as suggested by the with azatadine, chlorpheniramine, mepyramine, promethazine; most other first-generation not been studied for these properties. In vitro shown H1-antihistamines reduce release proinflammatory mediators mast cells basophils, chemotaxis...
To assess outcomes including efficacy, adverse effects, and quality of life (QOL) an adjustable thermoplastic mandibular advancement device (AT-MAD) fitted by otolaryngologist for obstructive sleep apnea (OSA) treatment.Prospective, nonrandomized, before-after study.Sixty-four adult patients (40 men 24 women) were recruited. Inclusion criteria OSA who had failed or refused treatment with continuous positive airway pressure surgery. Exclusion insufficient teeth, active intraoral disease,...
We previously showed that individuals with seasonal allergic rhinitis (SAR) had a reduced ability to condition air, which was improved by inflammation. hypothesized perennial (PAR) would air like SAR Because asthma usually have inflammation in the nose, we they PAR. performed prospective, parallel study on 15 normal subjects, subjects outside their allergy season, PAR, and asthma. Cold, dry (CDA) delivered nose temperature humidity of were measured before entering after exiting nasal cavity....
Radiofrequency inferior turbinate reduction (RFITR) of hypertrophy (ITH) is an effective way to treat patients with intractable nasal mucosal obstruction. The objective this study was assess smell ability, symptoms, grading (ITG), peak inspiratory flow (PNIF) chronic rhinitis (CR), and ITH before after RFITR. Patients CR ITH, aged 18–60 years, who underwent RFITR, were prospectively recruited. Smell ability (measured by detection threshold [SDT]), visual analog scale (VAS) ITG, PNIF 6–10...
The recommended drug for moderate to severe chronic rhinitis is intranasal steroids (INS). However, nasal congestion could be refractory and need additional treatments.We sought explore the benefit of oxymetazoline (Oxymet) plus INS on without inducing medicamentosa.We performed a 60-week, randomised, double-blind clinical trial in 50 patients, 18 years age or greater, with who had used cetirizine still congestion. Subjects were randomised receive 2 sprays 0.05% Oxymet each nostril twice...
Azelastine, a second-generation H1-receptor antagonist, is available for topical administration. The aim of the study was to evaluate effects intranasal azelastine on early-phase and late-phase allergic responses nasal hyper-responsiveness methacholine.Double-blind, placebo-controlled, two-way crossover in 20 subjects with seasonal rhinitis, out their allergy season.Subjects were randomly assigned receive either placebo or two puffs twice day (548 microg/d) 2 weeks followed by challenge...
Background Radiofrequency volumetric tissue reduction (RFVTR) of hypertrophic inferior turbinate (IT) is an effective way to treat patients with intractable nasal mucosal obstruction. We evaluated the effectiveness combined RFVTR and lateral outfracture (LO) IT in chronic rhinitis (CR) on obstruction, rhinorrhea, pruritus both short long term. Methods Seventy‐three CR who failed medical treatment were recruited undergo LO IT. Nasal congestion scores recorded before operation, immediately, 2...
Sinonasal polyposis represents a chronic inflammatory condition of unknown etiology. It is often associated with systemic diseases and characterized by nasal obstruction, reduction in sense smell, infection, impaired quality life. Endoscopy has enhanced the diagnosis management polyps. The initial approach medical management. Medical therapy consists administration intranasal steroids or short course steroids. Other treatments considered are use antibiotics, leukotriene modifiers,...
We have developed a method for measuring the temperature and relative humidity of air prior to after nasal conditioning used it study effect treatment with ipratropium bromide on ability nose condition cold, dry air. performed randomized, double-blind, placebo-controlled, two-way crossover studies an open in nonallergic subjects. The subjects were treated (84 μ g) or normal saline solution sprayed into cavity 15 min before measurement capacity. Cold, was delivered via mask, measured entering...
<h3>Background</h3> We have previously reported that preconditioning allergic subjects with hot, humid air (HHA) (temperature, 37°C; relative humidity >95%) in an environmental chamber resulted partial inhibition of the early response to nasal allergen challenge. <h3>Objective</h3> To investigate whether this inhibitory effect could be achieved by inhalation HHA via a face mask. <h3>Design</h3> Randomized, 4-way crossover study. <h3>Subjects</h3> Eighteen seasonal rhinitis participated...
Objectives/Hypothesis To compare outcomes of continuous positive airway pressure (CPAP) and the adjustable thermoplastic mandibular advancement splint (AT‐MAS) for obstructive sleep apnea treatment. Study Design Randomized crossover, noninferiority, tertiary center setting. Methods Fifty patients with a mean age 49.5 ± 10.6 years were enrolled. Inclusion criteria ≥18 years, apnea‐hypopnea index (AHI) ≥5 events/hour, oxygen saturation ≥70%. Exclusion temporomandibular joint disorders, severe...
Nasal obstruction is often impact on quality of life in allergic rhinitis (AR). The steam inhalation one widely used home remedies to soothe and open the nasal passages. Furthermore, may provide change objective airway assessment.To compare effect between patients with AR normal individuals, as well cross-sectional area cavity resistance (NAR) 2 groups.A prospective comparative, parallel group study was conducted individuals. Steam temperature 42-44°C inhaled. Variables obtained before after...
Although allergic rhinitis (AR) has not been acknowledged as a strong risk factor for obstructive sleep apnea (OSA), several pathophysiological linkages between these two conditions have frequently reported. However, epidemiological data relating to the prevalence of OSA in patients with AR remain scarce.To investigate at high among AR, and determine relationship severity AR.Patients aged ≥ 18 years diagnosis positive skin prick test were recruited from allergy clinic, Department...
We tested the hypothesis that decreasing nasal air volume (i.e., increasing turbinate blood volume) improves conditioning. performed a randomized, two-way crossover study on conditioning capacity of nose in six healthy subjects supine and upright position. Cold, dry (CDA) was delivered to via mask, temperature humidity were measured before it entered after exited cavity. The total water gradient (TWG) across calculated represents capacity. Nasal decreased significantly from baseline without...