A5057312745- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Toxin Mechanisms and Immunotoxins
- Parasites and Host Interactions
- vaccines and immunoinformatics approaches
- Synthesis and Biological Evaluation
- Transgenic Plants and Applications
- Macrophage Migration Inhibitory Factor
- Virology and Viral Diseases
- Immune Cell Function and Interaction
- Insect Pest Control Strategies
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Disorders and Syndromes
- Paraoxonase enzyme and polymorphisms
- Reproductive System and Pregnancy
- Trace Elements in Health
- Autoimmune and Inflammatory Disorders Research
- Global Health and Epidemiology
- Language, Linguistics, Cultural Analysis
- Gender, Education, and Development Issues
- Burkholderia infections and melioidosis
- Enzyme function and inhibition
- Ectopic Pregnancy Diagnosis and Management
- Genomics, phytochemicals, and oxidative stress
- Pancreatitis Pathology and Treatment
Rajendra Memorial Research Institute of Medical Sciences
2013-2022
Indian Council of Medical Research
2007-2022
Lovely Professional University
2021
Central Research Institute of Epidemiology
2013
Hemoglobin receptor is a vaccine candidate against visceral leishmaniasis .
Visceral leishmaniasis (VL) is one of the most neglected tropical diseases for which no vaccine exists. In spite extensive efforts, successful available against this dreadful infectious disease. To support development, an immunoinformatics approach was applied to screen potential MHC class-II-restricted epitopes that can activate immune cells. Initially, 37 derived from six stage-dependent, overexpressed antigens were predicted, presented by at least 26 diverse class-II allele. Based on a...
Leishmania donovani is the causative organism of neglected human disease known as visceral leishmaniasis which often fatal, if left untreated. The cysteine biosynthesis pathway may serve a potential drug target because it different from host and regulates downstream components redox metabolism parasites; essential for their survival, pathogenicity resistance. However, despite apparent dependency pathway, role L. synthase (LdCS) in resistance homeostasis has been unexplored. Herein, we report...
Summary In this phase III trial for diagnostics visceral leishmaniasis (VL) in India, we compared parasitological diagnosis with several serological tests: direct agglutination test (freeze dried; DAT‐FD), rK‐39 strip test, rK‐26 and a latex antigen detection urine (KAtex) 452 subjects from the endemic regions of Bihar, India. The were segregated into four categories: 230 confirmed patients, 52 probable cases, 70 non‐cases 100 healthy controls. first two groups used estimating sensitivity,...
Background Lesishmaniasis is a neglected tropical disease endemic in Bihar, India. Inappropriate health seeking behaviour of post kala-azar dermal leishmaniasis (PKDL) patients may increase the duration, severity and transmissibility. Simultaneously, lack knowledge perceived stigma also length delay receiving treatment. This ultimately effects elimination program. Methods A cross sectional study was conducted 120 confirmed PKDL patients, aged 18 years older. Data related to collected by...
Post kala-azar dermal leishmaniasis (PKDL) is a skin manifestation that usually develops after treatment of visceral (VL), major public health problem in India. The diagnosis and management PKDL complex. This the first case report from India which occurred paromomycin for VL an Indian patient.
Abstract To explore new protective measure against visceral leishmaniasis, reverse vaccinology approach was employed to identify key immunogenic regions which can mediate long-term immunity. In-depth computational analysis revealed nine promiscuous epitopes possibly be presented by 46 human leukocyte antigen, thereby broadening the worldwide population up 94.16%. This is of reasonable significance that most shared 100% sequence homology with other Leishmania species and could evoke a common...
Presence of asymptomatic individuals in endemic areas is common. The possible biomarkers once they get exposed to infection as well following conversion symptomatic disease are yet be identified.We identified Visceral leishmaniasis (VL) amongst rK39+sorted direct agglutination test positive (DAT+) healthy population and confirmed it by quantitative PCR(qPCR).The immunological determinants such Adenosine deaminase (ADA), Interferon gamma (IFN-γ), Tumour Necrosis Factor alpha (TNF-α)...
The unreliability of most the existing antibody-based diagnostic kits to discriminate between active and treated VL cases, relapse situation reinfection are a major hurdle in controlling cases Kala-azar an endemic area. An antigen targeted approaches can be attractive strategy overcome these problems. Hence, this study was focused on identifying Leishmania antigens, lies circulating immune complex (CICs), used for as well prognostic purposes. present conducted peripheral blood samples 115...
Although, the precise host defence mechanism(s) is not completely understood, T cell-mediated immune responses believed to play a pivotal role in controlling parasite infection. Here we target stage dependent over expressed gene. Here, consensus based computational approach was adopted for screening of potential major histocompatibility complex class I restricted epitopes. Based on analysis and previously published report, set 19 antigenic proteins derived from Leishmania donovani were...
Background: Treatment of post-kala-azar dermal leishmaniasis cases is paramount importance for kala-azar elimination; however, limited treatment regimens are available as now. Aim: To compare the effectiveness liposomal amphotericin B vs miltefosine in patients. Methodology: This was a randomized, open-label, parallel-group study. A total 100 patients post kala azar leishmaniasis, aged between 5 and 65 years were recruited, 50 each group (liposomal B) (miltefosine). Patients randomized to...
In the Indian state of Bihar, sensitivities and specificities direct agglutination tests (DAT) rK39 test strips for detection Leishmania donovani infection in humans were explored found to be generally good (92%-100%). When 172 asymptomatic individuals [16 'case-contacts' who lived same households as past or current, confirmed cases visceral leishmaniasis (VL) 156 other subjects from neighbouring households] tested, 36 (21%) individuals, including all 16 'case-contacts', seropositive using...
Leishmaniasis caused by Leishmania parasite is a global threat to public health and one of the most neglected tropical diseases. Therefore, discovery novel drug targets effective major challenge an important goal. obligate intracellular that alternates between sand fly human host. To survive establish infections, parasites scavenge internalize nutrients from Nevertheless, host cells presents mechanism like nutrient restriction inhibit microbial growth control infection. Zinc crucial for...