A5068969005- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Congenital Anomalies and Fetal Surgery
- Bacteriophages and microbial interactions
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
Christian Medical College & Hospital
2020-2024
Wellcome Trust
2021
Christian Medical College
2020
In April 2016, an indigenous monovalent rotavirus vaccine (Rotavac) was introduced to the National Immunization Program in India. Hospital-based surveillance for acute gastroenteritis conducted five sentinel sites from 2012 2020 monitor impact on various genotypes and reduction positivity at each site. Stool samples collected children under 5 years of age hospitalized with diarrhea were tested group A using a commercial enzyme immunoassay, strains characterized by RT-PCR. The proportion...
We measured the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and re-infections in an adult community-based cohort southern India.
Abstract Background From 2016, the Government of India introduced oral rotavirus vaccine into national immunization schedule. Currently, two indigenously developed vaccines (ROTAVAC, Bharat Biotech; ROTASIIL, Serum Institute India) are included in Indian program. We report disease burden and diversity genotypes from 2005 to 2016 a multi-centric surveillance study before introduction vaccines. Methods A total 29,561 stool samples collected (7 sites during 2005–2009, 3 2009 2012, 28 2012–2016)...
Abstract Rotaviruses (RVs) are the most common etiological agent of acute gastroenteritis among young children, even after vaccine introduction in low-income countries. A whole-genome classification representing 11 RV genes, was introduced for surveillance and characterization RVs. This study characterized circulating strains Vellore, India from 2002 to 2017 understand rotavirus strain diversity evolution using Whole genome sequencing (WGS) carried out on Illumina MiSeq. The 89% (92%...
Neonatal rotavirus infections are predominantly caused by distinct genotypes restricted to this age-group and mostly asymptomatic.Stool samples from neonates admitted for >48 h in neonatal intensive care units (NICUs) Vellore (2014-2015) Chennai (2015-2016) southern India, born at hospitals but not NICUs were tested ELISA genotyped hemi-nested RT-PCR.Of 791 neonates, 150 336 recruited NICUs, 305 five Vellore. Positivity rates the three settings 49.3% (74/150), 29.5% (99/336) 54% (164/305),...
ABSTRACT Neonatal rotavirus infections are predominantly caused by distinct genotypes restricted to this age-group and mostly asymptomatic. Stool samples from neonates admitted for >48 hours in neonatal intensive care units (NICUs) Vellore (2014-2015) Chennai (2015-2016) southern India, born at hospitals but not NICUs were tested ELISA genotyped hemi-nested RT-PCR. Of the 791 neonates, 150 336 recruited NICUs, 305 five Vellore. The positivity rates three settings 49.3% (74/150), 29.5%...