A5103226586- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Complement system in diseases
- Agricultural risk and resilience
- Flood Risk Assessment and Management
- Malaria Research and Control
- Pregnancy and preeclampsia studies
- Insect symbiosis and bacterial influences
- Hydrology and Drought Analysis
- Prosthetics and Rehabilitation Robotics
- Birth, Development, and Health
- Fatty Acid Research and Health
- COVID-19 epidemiological studies
- Helminth infection and control
- Hepatitis C virus research
- Hernia repair and management
- Insects and Parasite Interactions
- Appendicitis Diagnosis and Management
- Hepatitis Viruses Studies and Epidemiology
- Virology and Viral Diseases
- Trypanosoma species research and implications
- Salmonella and Campylobacter epidemiology
Delhi Pharmaceutical Science and Research University
2025
Government Medical College
2024
Regional Medical Research Centre
1999-2024
University of Nebraska–Lincoln
2019-2024
Regional Medical Research Centre
2000-2023
Indian Council of Medical Research
1994-2023
Regional Medical Research Centre
1994-2023
Utkal University
2023
Berhampur University
2020
Institute of Medical Sciences and Sum Hospital
2014-2017
In a placebo controlled trial, the effects of 21- and 10-day doxycycline treatments (200 mg/day) followed by single dose diethylcarbamazine (administered 4 months post treatment) on depletion Wolbachia endobacteria from Wuchereria bancrofti , filaricidal activity, amerlioration scrotal lymph vessel dilation were studied in 57 men Orissa, India. The 21-day course reduced W. 94% before administration. After 12 months, all patients with this treatment amicrofilaremic different (42.9%) (37.5%)...
Zika virus (ZIKV) infection to a pregnant woman can be vertically transmitted the fetus via placenta leading Congenital syndrome. This is characterized by microcephaly, retinal defects, and intrauterine growth retardation. ZIKV induces placental trophoblast apoptosis severe abnormalities in development of fetus. However, molecular mechanism behind ZIKV-induced trophoblasts remains unclear. We hypothesize that endoplasmic reticulum (ER) stress trophoblasts, sustained ER results apoptosis....
Since its re-emergence in 2005, chikungunya virus (CHIKV) transmission has been documented most Indian states. Information is scarce regarding the seroprevalence of CHIKV India. We aimed to estimate age-specific seroprevalence, force infection (FOI), and proportion population susceptible infection.We did a nationally representative, cross-sectional serosurvey, which we randomly selected individuals three age groups (5-8, 9-17, 18-45 years), covering 240 clusters from 60 districts 15 states...
Background: Hip dislocation and subluxation are frequent issues in children with cerebral palsy (CP), particularly those spastic forms of the condition. One strategies for managing these problems is use hip abduction orthoses, which help to prevent or treat deformities. The focus this study examine effects a modified dynamic orthosis addressing adductor tightness patient CP. Case Description Methods: case involved 6-year-old boy paraplegic CP who presented National Institute Locomotor...
Torticollis is a congenital condition caused by the shortening of sternocleidomastoid muscle, leading to abnormal head positioning with lateral tilt and contralateral rotation. Traditional cervical orthoses, such as static rotational control braces, often lack adjustability, comfort, dynamic functionality. This study aims design develop lightweight, adjustable, 3-dimensional tri-planar corrective torticollis brace. The proposed orthosis provides gradual correction in all three planes,...
Hydrocele and elephantiasis are 2 clinically very diverse often mutually exclusive chronic manifestations of human bancroftian filariasis. Plasma levels endothelin-1 (ET-1), a major angiogenic factor, tumor necrosis factor receptors (TNFRs) that regulate host inflammation have been associated with development filariasis, although their genetic basis not known.We studied polymorphisms ET-1 (Ala288Ser) TNFR-II (Met196Arg) genes by means the polymerase chain reaction confronting pairs primers...
Omega-3 fatty acids are important to pregnancy and neonatal development health. One mechanism by which omega-3 exert their protective effects is through serving as substrates for the generation of specialized pro-resolving lipid mediators (SPM) that potently limit resolve inflammatory processes. We recently identified SPM levels increased in maternal blood at delivery compared umbilical cord blood, suggesting placenta a potential site action SPM. To explore this hypothesis, we obtained human...
IntroductionIndia introduced a hepatitis-B (HB) vaccine in the Universal Immunization Program 2002–2003 on pilot basis, expanded to ten states 2007–2008 (phase-1), and entire country 2011–2012 (phase-2). We tested sera from nationally representative serosurvey conducted duing 2017, estimate seroprevalence of different markers HB infection among children aged 5–17 years India assess impact vaccination.MethodsWe 8273 for estimated weighted age-group specific who were chronically infected...
Introduction Obesity during pregnancy increases the risk for maternal complications like gestational diabetes, preeclampsia, and inflammation. Maternal obesity also of childhood obesity, intrauterine growth restriction (IUGR) diabetes to offspring. Increased circulating free fatty acids (FFAs) in due adipose tissue lipolysis induces lipoapoptosis hepatocytes, cholangiocytes, pancreatic-β-cells. During third trimester human pregnancy, there is an increase release FFAs into circulation. It...
Background: Lymphatic filariasis (LF) persists as a public health problem in India. Despite more than ten rounds of mass drug administration (MDA), LF continues to be endemic the Dhenkanal district Odisha. Hence, we assessed coverage and compliance MDA program explored factors affecting it district. Methods: An explanatory mixed-method study was conducted, wherein for quantitative survey, 552 participants aged 2 years above were recruited following multistage cluster random sampling during...
Fifty-two adult patients with cerebral malaria were randomly categorized into two groups to receive either quinine dihydrochloride (Qn) alone or a combination of Qn and pentoxifylline (Px). Thirty-two them received intravenous (i.v.) (group I), 20 II) i.v. along parenteral Px support (10 mg/kg/day) for the initial 3 days. There was significant improvement in coma resolution time group II (21.6 +/- 13.9 h) comparison I (63.5 19.7 (P < 0.001), mortality 25% against 10% receiving adjunct >...
Filaria-specific antibodies of immunoglobulin (Ig) G, IgE, and IgM isotypes have been correlated with acquired immunity in the literature, but status filaria-specific IgA its role human filariasis has not addressed. The present study attempts to fill this lacuna.Both total different developmental stages filarial parasites were quantified by solid-phase immunoassays 412 clinically parasitologically defined cases occurring an area endemic for bancroftian Orissa, India.Compared other clinical...
Abstract Bruton’s tyrosine kinase (Btk) mutant CBA/N mice show delayed clearance of injected microfilaria (mf) compared with wild-type CBA/J mice. Anti-mf T cells from make relatively more IFN-γ than those The anti-mf cell proliferative responses are also greater in This immune phenotype is not restricted to filarial Ags, because immunization pure proteins yields magnitude skewed away Th2 cytokines increased reflected increases both precursor frequencies and clonal burst sizes responding...
Journal Article Lymphatic filariasis and malaria: concomitant parasitism in Orissa, India Get access B Ravindran, Ravindran ∗ aDivision of Applied Immunology Regional Medical Research Centre, Indian Council Research, Bhubaneswar 751 016, ∗Address for correspondence: Dr B. Deputy Director, Division Immunology, Chandrasekharpur, India. Search other works by this author on: Oxford Academic PubMed Google Scholar P.K Sahoo, Sahoo A.P Dash bDivision Entomology, Transactions The Royal Society...
A spectrum of clinical manifestations is a feature human lymphatic filariasis. The acute disease characterized by periodic and self limiting episodes adenolymphangitis, fever associated constitutional symptoms, while the chronic includes long lasting such as lymphoedema and/or hydrocoele. microfilariae carriers are generally free symptoms. In present study circulating Tumour Necrosis Factor (TNF‐α) was measured in bancroftian filariasis with different manifestations. Significantly elevated...
SUMMARY Studies on immune responses to parasites have been undertaken in filariasis with a view understand protective immunity, pathogenesis of the disease process and mechanisms deviation. However none investigations conducted so far antibody addressed issue immunogenicity filarial carbohydrate antigens human lymphatic filariasis. In this communication we report details relative protein contents various developmental stages proteins (Fil.Pro) carbohydrates (Fil.Cho) different clinical...
The existence and the nature of protective immunity in human filariasis continues to be a subject intense debate. While there is no broad consensus on functional against larval adult stage parasites, anti-microfilarial has been demonstrated mediated by antibodies microfilarial sheath. In present study, circulating filarial antigens (CFA), marker active infection Bancroftian filariasis, was found inversely associated with sheath cohort 411 subjects representing all categories across clinical...
Cellular hyporesponsiveness observed during helminth infections is attributed to factors such as antigen-presenting cells (APC) dysfunction, increased interleukin-10(IL-10), regulatory T and induction of CD4+ (Th)-cell apoptosis. Increased Fas ligand (FasL) expression on the surface B-1 apoptosis Th by FasL-expressing due infection were demonstrated in murine model where profile FasL expression, Th-cell correlation between these two populations clinical filariasis remain unknown. In this...