A5101903403- Research on Leishmaniasis Studies
- Antifungal resistance and susceptibility
- Trypanosoma species research and implications
- Fungal Infections and Studies
- Toxin Mechanisms and Immunotoxins
- Pneumocystis jirovecii pneumonia detection and treatment
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Hepatitis C virus research
- Tuberculosis Research and Epidemiology
- Pharmaceutical studies and practices
- Oral and Maxillofacial Pathology
- Cardiac Imaging and Diagnostics
- Innovations in Medical Education
- Acute Lymphoblastic Leukemia research
- Trigeminal Neuralgia and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Pharmacogenetics and Drug Metabolism
- Sinusitis and nasal conditions
- Parasites and Host Interactions
- Congenital Heart Disease Studies
- Neurosurgical Procedures and Complications
- Vascular anomalies and interventions
Drugs for Neglected Diseases Initiative
2015-2025
University of Colorado Anschutz Medical Campus
2022
Sri Aurobindo Institute of Medical Sciences
2021
Iowa Academy of Science
2021
Johnson & Johnson (India)
2017-2020
Janssen (India)
2017-2020
Jamia Millia Islamia
2020
All India Institute of Medical Sciences
2019
Drugs for Neglected Diseases Initiative India
2018
University of Miami
2014-2017
Background AmBisome therapy for VL has an excellent efficacy and safety profile been adopted as a first-line regimen in Bangladesh. Second-line treatment options are limited should preferably be given short course combinations order to prevent the development of resistant strains. Combination regimens including AmBisome, paromomycin miltefosine have proved safe effective India. In present study, these same were assessed field conditions Methods The three combination regimens: 5 mg/kg single...
Visceral leishmaniasis (VL) in patients with human immunodeficiency virus (HIV) presents an increasingly important patient cohort areas where both infections are endemic. Evidence for treatment is sparce, no high-quality studies from the Indian subcontinent.This a randomized, open-label, parallel-arm, phase 3 trial conducted within single hospital Patna, India. One hundred and fifty aged ≥18 years serologically confirmed HIV parasitologically VL were randomly allocated to 1 of 2 arms, either...
Objectives: Flucytosine (5FC) is a key medication for treating cryptococcal meningoencephalitis (CM), condition frequently affecting people living with HIV. The current 5FC dosing regimen an immediate release (IR) tablet formulation that requires administration four times daily, posing challenges compliance and patients who cannot tolerate oral medicines [1,2]. To tackle these issues, sustained-release (SR) pellet of currently in development. development program used model-informed drug...
ABSTRACT This paper presents a case study demonstrating the application of model‐informed drug development (MIDD) and early modeling integration in sustained release (SR) formulation flucytosine for cryptococcal meningoencephalitis (CM) HIV‐infected patients. The aimed to showcase value physiologically based pharmacokinetic (PBPK) biopharmaceutics (PBBM) guiding decisions optimizing therapeutic strategies throughout development. MIDD strategy started with PBPK model on limited literature...
The opportunistic fungal infection cryptococcal meningoencephalitis is a major cause of death among people living with HIV in sub-Saharan Africa. We report pharmacokinetic (PK) and safety data from randomized, four-period crossover phase I trial three sustained-release (SR) oral pellet formulations 5-flucytosine conducted South These were developed to require less frequent administration, provide convenient alternative the current immediate release (IR) formulation, A. Formulations B, C, D...
Background Few prospective data exist on incidence of post kala-azar dermal leishmaniasis (PKDL) and visceral (VL) relapse after different treatment regimens. Methodology/Principal findings A Phase IV trial included 1761 VL patients treated between 2012–2014 with single dose AmBisome (SDA; N = 891), miltefosine-paromomycin (Milt-PM; n 512), or AmBisome-miltefosine (AmB-Milt; 358). Follow-up for PKDL was scheduled 6, 12 24 months treatment, lasting until 2017. Patients lesions consistent were...
Background In low-income and middle-income countries, affordable direct-acting antivirals are urgently needed to treat hepatitis C virus (HCV) infection.The combination of ravidasvir, a pangenotypic non-structural protein 5A (NS5A) inhibitor, sofosbuvir has shown efficacy safety in patients with chronic HCV genotype 4 infection.STORM-C-1 trial aimed assess the ravidasvir plus diverse population adults chronically infected HCV.Methods STORM-C-1 is two-stage, open-label, phase 2/3 single-arm...
Abstract Cryptococcal meningoencephalitis (CM) is an opportunistic fungal infection and a major cause of death among people living with human immunodeficiency virus in sub‐Saharan Africa. 5‐flucytosine (5‐FC) unique, brain‐permeable antifungal agent used to reduce mortality from CM prevent disease individuals carrying cryptococcal antigen. 5‐FC has short plasma half‐life, requiring 6‐hourly oral dosing immediate‐release (IR) formulation, significant challenge hospital outpatient settings,...
Background In 2010, WHO recommended the use of new short-course treatment regimens in kala-azar elimination efforts for Indian subcontinent. Although phase 3 studies have shown excellent results, there remains a lack evidence on wider population and safety effectiveness these under field conditions. Methods This was an open label, prospective, non-randomized, non-comparative, multi-centric trial conducted within public health facilities two highly endemic districts specialist referral centre...
Background An earlier open label, prospective, non-randomized, non-comparative, multi-centric study conducted within public health facilities in Bihar, India (CTRI/2012/08/002891) measured the field effectiveness of three new treatment regimens for visceral leishmaniasis (VL): single dose AmBisome (SDA), and combination therapies miltefosine (AmB+Milt) paromomycin (Milt+PM) up to 6 months follow-up. The National Vector Borne Disease Control Program (NVBDCP) recommended an extended follow at...
Abstract Klippel‐Trenaunay syndrome is a congenital disorder characterised by the triad of cutaneous vascular nevi, soft tissue or bony hypertrophy, and varicose veins venous malformations involving one more extremities. An incidence thromboembolism up to 22% has been reported in this disorder. Also but rare development trophic changes. Herein, we report case male with syndrome, deep vein thrombosis, ulceration, death due recurrent pulmonary embolism.
Introduction: Physicians in India display an enthusiasm for continuing medical education (CME), however a proper system facilitation and organisation of CME activities is yet to evolve the country. Methods: A questionnaire-based survey was conducted among 751 physicians from eight specialties across data retrieved analysed at individual physician collective specialty-specific levels. Results: The surveyed considered case presentations (73%), live speaker programmes (70%) round-table...
A 50-year-old athletic man presented with two weeks of debilitating "sinus" headache, continuous left nostril drainage, persistent cough, no history head trauma.His nasal discharge was unilateral, worse coughing or leaning forward (Fig. 1), one clear drop every 2-3 seconds.Analysis demonstrated beta-2 transferrin, a transferrin isoform found almost exclusively in cerebrospinal fluid (CSF).Brain MRI showed cribriform ethmoid sinus fractures.Endoscopy revealed small bony defect his plate 2),...
Transradial catheterization is associated with lower complication rates; however limited information available regarding techniques to overcome unusual complications. We present a case of 58-year-old male suspected non-ST-elevated myocardial infarction who underwent transradial coronary angiography complicated by guidewire embolization into the radial artery and subsequent access loss. Successful retrieval embolized was achieved re-accessing same use 2 mm gooseneck microsnare. This technique...