A5075075802- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Supply Chain and Inventory Management
- Parasitic Infections and Diagnostics
- Manufacturing Process and Optimization
- Design Education and Practice
- Auction Theory and Applications
- Scheduling and Optimization Algorithms
- Bayesian Modeling and Causal Inference
- Simulation Techniques and Applications
- Product Development and Customization
- Optimization and Search Problems
- HIV/AIDS drug development and treatment
- Healthcare Policy and Management
- Malaria Research and Control
- Technology Assessment and Management
- Systems Engineering Methodologies and Applications
- Capital Investment and Risk Analysis
- HIV Research and Treatment
- Distributed and Parallel Computing Systems
- Image Processing and 3D Reconstruction
- Business Process Modeling and Analysis
- Fungal Infections and Studies
- Distributed Sensor Networks and Detection Algorithms
- Trace Elements in Health
National Institute of Animal Biotechnology
2015-2025
Manipal Academy of Higher Education
2025
Purdue University West Lafayette
1993-2022
Dr. Panjabrao Deshmukh Memorial Medical College
2018
Jawaharlal Nehru University
2012-2015
Indian Institute of Remote Sensing
2014
IBM (United States)
2012
Texas A&M University
2007-2010
Mitchell Institute
2008-2010
University of Massachusetts Amherst
2000-2008
The opportunistic fungal infection cryptococcal meningoencephalitis is a major cause of death among people living with HIV in sub-Saharan Africa. We report pharmacokinetic (PK) and safety data from randomized, four-period crossover phase I trial three sustained-release (SR) oral pellet formulations 5-flucytosine conducted South These were developed to require less frequent administration, provide convenient alternative the current immediate release (IR) formulation, A. Formulations B, C, D...
Toxoplasma gondii, an apicomplexan parasite, has over 75% of its genes containing introns; however, the role RNA splicing in regulating gene expression remains unclear. Here, we demonstrate that pre-mRNA factor Cdc5 is part a large spliceosomal complex essential for maintaining transcriptome integrity Toxoplasma. TgCdc5 depletion results inhibition with widespread changes affecting several parasite processes, including lytic cycle, DNA replication and repair, protein folding degradation....
Plasmodium falciparum origin recognition complex 1 (ORC1) protein has been implicated in DNA replication and silencing var gene family. However, the mechanism domain structure of ORC1 related to regulation family are unknown. Here we show that unique N-terminus PfORC1 (PfORC1N 1–238 ) is targeted nuclear periphery vivo this region binds telomeric vitro due presence a leucine heptad repeats. Like PfORC1N , endogenous full length ORC1, was found be associated with sub repeat regions promoters...
Manufacturing enterprise decisions can be classified into four groups: business decisions, design engineering and production decisions. Numerous physical software simulation techniques have been used to evaluate specific by predicting their impact on the system as measured one or more performance measures. We focus where discrete-event models perform that evaluation. argue such an evaluation is limited in time scope, does not capture potential of these whole enterprise. propose integrating...
Eukaryotic PCNAs (proliferating-cell nuclear antigens) play diverse roles in nucleic acid metabolism addition to DNA replication. Plasmodium falciparum, which causes human malaria, harbours two PCNA homologues: PfPCNA1 and PfPCNA2. The functional role of distinct the parasite still eludes us. In present study, we show that, whereas both PfPCNAs share structural biochemical properties, only functionally complements ScPCNA mutant forms replication foci parasite, PfPCNA2 fails do. Although...
Plasmodium falciparum Origin Recognition Complex subunit 1 (PfORC1) has been implicated in DNA replication and var gene regulation. While the C-terminus is involved replication, specific role of N-terminus suggested regulation a Sir2-dependent manner. PfORC1 localized at nuclear periphery, where clustering chromosomal ends early stage parasite development may be crucial for subtelomeric expression. Upon disassembly telomeric clusters later stages development, ORC1 distributed nucleus...
Abstract The protozoan parasite Toxoplasma gondii is thought to rely on RNA processing accomplish the differential gene expression needed during life cycle stage transitions. Here, we show how capping, first major pre-mRNA event, safeguards transcript homeostasis in . A functional capping system of consists separate triphosphatase, guanylyltransferase, and guanine-N7-methyltransferase enzymes, which together add 5’ 7-methylguanosine (m 7 G) cap RNA. vitro generated capped RNAs bind...
Abstract Cryptococcal meningoencephalitis (CM) is an opportunistic fungal infection and a major cause of death among people living with human immunodeficiency virus in sub‐Saharan Africa. 5‐flucytosine (5‐FC) unique, brain‐permeable antifungal agent used to reduce mortality from CM prevent disease individuals carrying cryptococcal antigen. 5‐FC has short plasma half‐life, requiring 6‐hourly oral dosing immediate‐release (IR) formulation, significant challenge hospital outpatient settings,...
Abstract The need to provide cost-effective manufacturing technologies is critical in today's globally competitive environment. ability make sound decisions about the cost effectiveness of new key achieving affordability goals future products and systems. Effective assessments for investment applications must reflect total financial impact trade-offs between performance. Most traditional tools modeling, reasoning, computing are crisp, deterministic, precise character. By crisp we mean...
In February, 2010, the National Science Foundation sponsored a workshop that brought together forty-seven representatives from US Department of Defense, Air Force, NASA, Institute for Standards and Technology, Foundation, academic researchers systems engineering, engineering design, psychology cognition, organization design innovation, economics mathematics to construct research program into foundational issues underlie how we develop large-scale complex such as aircraft, spacecraft, launch...
A new methodology is developed for optimal infeed control of cylindrical plunge grinding cycles. Unlike conventional cycles having a few sequential stages with discrete rates, the allows continuous variation rate to further reduce cycle time. Distinctive characteristics variable rates were investigated by applying dynamic programming simulation cycle. The simulated found consist distinct segments predominant constraints. This provided basis an policy whereby determined according active...