A5058107369- Neuroscience and Neuropharmacology Research
- Fungal Infections and Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Antifungal resistance and susceptibility
- Neurotransmitter Receptor Influence on Behavior
- Helminth infection and control
- Pneumocystis jirovecii pneumonia detection and treatment
- Veterinary Pharmacology and Anesthesia
- Trypanosoma species research and implications
- Protease and Inhibitor Mechanisms
- Research on Leishmaniasis Studies
- Toxin Mechanisms and Immunotoxins
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Amino Acid Enzymes and Metabolism
- Tuberculosis Research and Epidemiology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Actinomycetales infections and treatment
- Pulmonary Hypertension Research and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Traditional Chinese Medicine Analysis
- Genetic Neurodegenerative Diseases
- Agricultural safety and regulations
Drugs for Neglected Diseases Initiative
2017-2025
Centre Hospitalier Intercommunal de Fréjus Saint-Raphaël
2020
Innovative Medicines for Tuberculosis Foundation
2018
Merck Serono (Italy)
2006-2008
Merck Serono (Switzerland)
2007-2008
Battelle
1993-1994
Bracco (Switzerland)
1994
Centre National de la Recherche Scientifique
1987-1993
Université Claude Bernard Lyon 1
1987-1993
Queen's University
1990
Macrophage elastase (MMP-12) is involved in the inflammatory process of chronic obstructive pulmonary disease (COPD). The aim this study was to investigate mice effect MMP-12 inhibition on induced by cigarette smoke (CS) or lipopolysaccharide (LPS) exposure airways.C57BL/6 were given, orally, either selective inhibitor AS111793 (3, 10, 30 and 100 mg kg(-1)), PDE-4 roflumilast (3 kg(-1)) vehicle, then exposed CS (for 3 days) LPS (100 microg mL(-1), min). Subsequent last exposure,...
The efficacy of the standardized four-drug regimen (comprising isoniazid, rifampin, pyrazinamide, and ethambutol) for treatment tuberculosis (TB) is menaced by emergence multidrug-resistant (MDR) extensively drug-resistant (XDR) strains Mycobacterium . Intensive efforts have been made to develop new antibiotics or repurpose old drugs, several these are currently being evaluated in clinical trials their antitubercular activity.
The opportunistic fungal infection cryptococcal meningoencephalitis is a major cause of death among people living with HIV in sub-Saharan Africa. We report pharmacokinetic (PK) and safety data from randomized, four-period crossover phase I trial three sustained-release (SR) oral pellet formulations 5-flucytosine conducted South These were developed to require less frequent administration, provide convenient alternative the current immediate release (IR) formulation, A. Formulations B, C, D...
Objectives: Flucytosine (5FC) is a key medication for treating cryptococcal meningoencephalitis (CM), condition frequently affecting people living with HIV. The current 5FC dosing regimen an immediate release (IR) tablet formulation that requires administration four times daily, posing challenges compliance and patients who cannot tolerate oral medicines [1,2]. To tackle these issues, sustained-release (SR) pellet of currently in development. development program used model-informed drug...
ABSTRACT This paper presents a case study demonstrating the application of model‐informed drug development (MIDD) and early modeling integration in sustained release (SR) formulation flucytosine for cryptococcal meningoencephalitis (CM) HIV‐infected patients. The aimed to showcase value physiologically based pharmacokinetic (PBPK) biopharmaceutics (PBBM) guiding decisions optimizing therapeutic strategies throughout development. MIDD strategy started with PBPK model on limited literature...
Abstract c‐Jun N‐terminal kinase (JNK), a member of the mitogen‐activated protein family, is activated in response to number extracellular stimuli, including inflammatory cytokines, UV irradiation and ischaemia. A large body evidence supports role for JNK signalling stress‐induced apoptosis. It has been hypothesized that may contribute apoptotic by regulating intrinsic cell death pathway involving mitochondria. Here, we examined hippocampal CA1 neurones following transient ischaemia gerbils....
Macrophage metalloelastase (MMP-12) is described to be involved in pulmonary inflammatory response. To determine the mechanisms linking MMP-12 and inflammation, we examined effect of recombinant human (rhMMP-12) catalytic domain on IL-8/CXCL8 production cultured airway epithelial (A549) cells. Stimulation with rhMMP-12 resulted a concentration-dependent synthesis 6 h later. Similar results were also observed BEAS-2B bronchial In A549 cells, synthetic matrix metalloproteinase (MMP) inhibitors...
Aims Emodepside is an anthelmintic, originally developed for veterinary use. We investigated in healthy subjects the safety, and pharmacokinetics of a liquid service formulation (LSF) immediate release (IR) tablet emodepside 2 randomised, parallel‐group, placebo‐controlled, Phase I studies. Methods Seventy‐nine 10 cohorts single ascending dose study 24 3 ascending‐dose multiple were enrolled. as LSF was administered orally 1–40‐mg doses days 5 or mg once daily 10‐mg twice doses,...
Based on their proven ability, in animal models of stroke, to reduce damage brain grey matter, many drugs have been tested clinical trials but without success. Failure save axons from injury and protect functional outcome has proposed as the major reason for this lack We previously demonstrated two rodent cerebral ischaemia, that AS601245 (1,3-benzothiazol-2-yl (2-([2-(3-pyridinyl) ethyl] amino)-4 pyrimidinyl) acetonitrile), an inhibitor c-Jun NH(2)-terminal kinase (JNK), neuroprotective...
Abstract Cryptococcal meningoencephalitis (CM) is an opportunistic fungal infection and a major cause of death among people living with human immunodeficiency virus in sub‐Saharan Africa. 5‐flucytosine (5‐FC) unique, brain‐permeable antifungal agent used to reduce mortality from CM prevent disease individuals carrying cryptococcal antigen. 5‐FC has short plasma half‐life, requiring 6‐hourly oral dosing immediate‐release (IR) formulation, significant challenge hospital outpatient settings,...
Abstract: The subcellular distribution of the protein tyrosine hydroxylase (TH) after fractionation rat brain tissue was studied by a sensitive technique immunoblot quantification in dopaminergic nigrostriatal and dorsal noradrenergic pathways ventrolateral medulla. This repartition indicates that all catecholaminergic regions cell bodies studied, contribution nerve endings to total TH amount is very low (< 7%), contrast observed terminal fields. correlative determination activity same...
Gonorrhea is a sexually transmitted infection for which antibiotic treatment options have declined due to increasing resistance. Zoliflodacin, an investigational oral spiropyrimidinetrione with activity against Neisseria gonorrhoeae strains that are multidrug-resistant, including third-generation cephalosporins, in phase III development uncomplicated gonorrhea. This I, parallel, open-label, randomized, crossover study healthy adults evaluated the effect of food on pharmacokinetics single 3...
Abstract The aim of the present work was to determine if noradrenergic neurons anterior and posterior subregions locus coeruleus exhibit a difference in reactivity response sodium nitroprusside‐induced arterial hypotension, pharmacological induction tyrosine hydroxylase by RU24722 modifies this hypotensive stimulus. Previous findings have demonstrated that administration increases concentration rat two different mechanisms subregions. goal study measure vivo changes catecholaminergic...
Abstract: In vivo voltammetry or microdialysis was used to monitor catecholaminergic metabolism in the C1 region of ventrolateral medulla oblongata anesthetized rats. allowed recording a catechol oxidation current (CA.OC) peak this region. This CA.OC suppressed after inhibition monoamine oxidase by pargyline tyrosine hydroxylase α‐methyl‐ p ‐tyrosine and markedly increased blockade dopamine‐ β ‐hydroxylase FLA 63. Similar results were found when intracerebral coupled with HPLC...
The objective of this study was to investigate under controlled conditions the effects fentanyl on rat locus coeruleus catechol oxidation current. Using differential normal pulse voltammetry combined with electrochemically treated carbon fiber electrodes measure current, catecholamine metabolism can be reliably monitored. Male Sprague–Dawley rats weighing 500–600 g had implanted into halothane – O 2 air anesthesia ventilation and muscle relaxation. Experiments consisted four groups given...
Nocardiopsis species are aerobic, gram-positive, non-acid fast rods isolated from soil, waters, and animals. They opportunistic human pathogens, but very few cases have been published so far. We report the first case of fatal pulmonary infection related to dassonvillei in an immunocompetent patient with chronic obstructive disease.