A5040269731- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Prostate Cancer Treatment and Research
- Fish Ecology and Management Studies
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Aldose Reductase and Taurine
- Bone health and treatments
- Lung Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Esophageal Cancer Research and Treatment
- Fish Biology and Ecology Studies
- Advanced Radiotherapy Techniques
- RNA Research and Splicing
- MicroRNA in disease regulation
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Bone and Dental Protein Studies
- Immune Response and Inflammation
- Crystallization and Solubility Studies
- Bacterial biofilms and quorum sensing
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
Wenzhou Medical University
2021-2024
First Affiliated Hospital of Zhengzhou University
2019-2024
Sichuan Agricultural University
2013-2022
Peking University First Hospital
2016-2020
Peking University
2016-2020
Chinese PLA General Hospital
2014-2015
Dana-Farber Brigham Cancer Center
2011
Brigham and Women's Hospital
2011
University of Chicago Medical Center
2011
Dana-Farber Cancer Institute
2011
Previous studies on the systemic immune-inflammation index (SII), which is based platelet, neutrophil and lymphocyte counts, as a prognostic marker in patients with colorectal cancer (CRC) yielded inconsistent results. The aim of this study was to evaluate clinicopathological role SII CRC via meta-analysis.A comprehensive literature survey performed PubMed, Web Science, Embase Cochrane Library databases include published up 6 April 2020. Pooled hazard ratios (HRs) odds (ORs) 95% confidence...
Abstract The occurrence of radioresistance is a clinical obstacle to endometrial cancer (EC) treatment and induces tumor relapse. In this study, we found that tumor-associated macrophages (TAMs) enriched in EC specimens were determined present an M2-like phenotype. vitro, the coculture M2-polarized significantly downregulated radiosensitivity cells by releasing exosomes. Hsa_circ_0001610 was be abundant exosomes derived from (EXOs), hsa_circ_0001610 knockdown eliminated reduction effect EXOs...
Programmed cell death ligand 1 (PD-L1) expression has been shown to associate with poor prognosis in a variety of solid tumors. However, the prognostic value PD-L1 cervical cancer is still controversial. Therefore, we carried meta-analysis investigate and clinicopathological impact cancer. A comprehensive literature search was performed PubMed, Embase, Web Science, Cochrane Library. The correlation between overall survival (OS), progression-free (PFS), features analyzed by hazard ratios...
BACKGROUND: High expression of CD14(+)HLA-DR-/low myeloid-derived suppressor cells (MDSCs) is correlated with immunosuppressive activity in various cancers, however, no studies have shown a correlation these clinical outcomes small-cell lung cancer (SCLC) patien ts. OBJECTIVE: The purpose the study was to investigate number, frequency and significance MDSCs SCLC patients. METHODS: peripheral blood 42 patients 37 healthy controls analyzed by using flow cytometry. relationships between number...
Aldo-keto reductase 1C3(AKR1C3) is an enzyme involved in prostaglandins metabolism. Studies suggest that AKR1C3 has a pivotal role the radioresistance of esophageal cancer and non-small-cell lung cancer, yet prostate cells radiation resistance not been clarified. In our study, we established stable overexpressing cell line (AKR1C3-over) derived from DU145 its control (Control). We conducted colony formation assay to determine used chemical inhibitor detect whether it can restored sensitivity...
Purpose: Accumulating studies have investigated the prognostic and clinical significance of programmed death ligand-1 (PD-L1) expression in patients with hepatocellular carcinoma (HCC); however, results were conflicting inconclusive. We conducted a meta-analysis to combine controversial data precisely evaluate this issue. Methods: Relevant thoroughly searched on PubMed, Web Science, Embase until April 2016. Eligible evaluated by selection criteria. Hazard ratio (HR) 95% confidence interval...
Programmed death-ligand 1 (PD-L1) was the first identified ligand of programmed death-1 (PD-1). PD-1/PD-L1 interactions inhibit T cell-mediated immune responses, limit cytokine production, and promote tumor escape. Recently, many studies have investigated prognostic value PD-L1 expression in patients with melanoma. However, results these analyses remain a subject debate. We therefore carried out meta-analysis to identify role melanoma.A thorough medical literature search performed databases...
Abstract Exploring the mechanism of breast cancer metastasis and searching for new drug therapeutic targets are still focuses current research. RNA-binding proteins (RBPs) may affect by regulating alternative splicing (AS) during epithelial-mesenchymal transition (EMT). We hypothesised that EMT development in cells, expression level RBPs gene AS pattern cell were significantly changed on a genome-wide scale. Using GEO database, this study identified differentially expressed differential...
Platelet to lymphocyte ratio (PLR) is a parameter reflecting inflammatory responses in patients with cancer. Several studies have investigated the prognostic value of PLR colorectal cancer (CRC); however, results are controversial. Thus, we carried out meta-analysis evaluate association between and CRC prognostication. Relevant articles were retrieved through PubMed, Embase, Web Science, pooled hazard (HR) 95% confidence interval (CI) computed by using STATA V.12.0. Both random-effects model...
Abstract Purpose This study aims to identify predictive local recurrence risk factors and site-specific pattern of upper tract urothelial carcinoma (UTUC) with different primary tumor locations. Methods Three hundred eighty-nine UTUC patients radical nephroureterectomy were included in this study. Univariate multivariate Cox proportional hazards regressions performed measure the recurrence. We also mapped position sites stratified by Results A total 73 (18.7%) developed within a median...
Acanthamoeba species are among the most ubiquitous protists that widespread in soil and water act as both a replicative niche vectors for dispersal. They important human intracellular pathogens, causing keratitis (AK) severely damaging cornea. The sympatric lifestyle within host amoeba-resisting microorganisms (ARMs) promotes horizontal gene transfer (HGT). However, genomic diversity of only A. castellanii polyphaga has been widely studied, pathogenic mechanisms remain unknown. Thus, we...
Interleukin-35 (IL-35) has recently been implicated in tumor immunity. The aim of this study was to explore the clinical role plasma IL-35 patients with non-small cell lung cancer (NSCLC). Plasma collected from 106 NSCLC cases and 78 healthy controls (HC) were subjected enzyme-linked immunosorbent assay (ELISA) relationships between levels characteristics evaluated. correlation overall survival analyzed using Kaplan–Meier method. prognostic value tested univariate multivariate analysis....
Introduction: The present study aimed to explore the role of miR-499a-5p and its molecular mechanism in cervical cancer (CC). Methods: Quantitative real-time PCR (QRT-PCR) Western blotting were performed detect expression eukaryotic translation initiation factor 4E (eIF4E) CC tissues cell lines. proliferation, migration, invasion cells detected by MTT assay, wound healing Transwell assay. Apoptosis was evaluated flow cytometry alterations apoptosis-related genes. effect on...
Objective To explore the prognostic value of serum interleukin-17 (IL-17) and vascular endothelial growth factor (VEGF) levels in patients with small cell lung cancer (SCLC). Materials Methods IL-17 VEGF were determined by a commercially available ELISA method. Results Serum higher SCLC group than control (p<0.001 p<0.0001, respectively). In addition, there was significant correlation between VEGF. The level showed correlations tumor stage metastasis, while significantly associated...
Abstract Enterococcus faecalis is one of the main pathogens that causes hospital-acquired infections because it intrinsically resistant to some antibiotics and often capable biofilm formation, which plays a critical role in resisting external environment. Therefore, attacking biofilms potential therapeutic strategy for caused by E. . Current research indicates diacerein used treatment osteoarthritis showed antimicrobial activity on strains gram-positive cocci vitro. In this study, we tested...
Abstract Background Immunogenic cell death (ICD) is a type of regulated that capable initiating an adaptive immune response. Induction ICD may be potential treatment strategy, as it has been demonstrated to activate the tumor‐specific Aims The biomarkers and their relationships with tumor microenvironment, clinical features, immunotherapy response are not fully understood in context. Therefore, we conducted pan‐cancer analyses gene signatures across 33 cancer types from Cancer Genome Atlas...