A5101400000- Diabetes Treatment and Management
- Biofuel production and bioconversion
- Pancreatic function and diabetes
- Enzyme Catalysis and Immobilization
- Catalysis for Biomass Conversion
- Metal-Organic Frameworks: Synthesis and Applications
- Diabetes and associated disorders
- Microbial Metabolic Engineering and Bioproduction
- X-ray Diffraction in Crystallography
- Metabolism, Diabetes, and Cancer
- Crystallization and Solubility Studies
- Natural product bioactivities and synthesis
- Metal complexes synthesis and properties
- Microbial Metabolites in Food Biotechnology
- Chronic Kidney Disease and Diabetes
- Plant biochemistry and biosynthesis
- Acute Kidney Injury Research
- Food Quality and Safety Studies
- Chromatography in Natural Products
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Genomics, phytochemicals, and oxidative stress
- Odor and Emission Control Technologies
- Ferroptosis and cancer prognosis
Shenzhen University
2019-2024
Nanjing Polytechnic Institute
2007-2024
Chinese University of Hong Kong
2024
University of Hong Kong
2024
Hebei University of Chinese Medicine
2023
Huazhong University of Science and Technology
2023
Hubei Cancer Hospital
2023
Nanjing Library
2020
Nanjing Tech University
2017
Peking University
2009
Roux-en-Y gastric bypass surgery (RYGB) improves the first phase of glucose-stimulated insulin secretion (GSIS) in patients with type 2 diabetes. How it does so remains unclear. Farnesoid X receptor (FXR), nuclear bile acids (BAs), is implicated bariatric surgery. Moreover, transient potential ankyrin 1 (TRPA1) channel expressed pancreatic β-cells and involved secretion. We aimed to explore role BAs/FXR TRPA1 improved GSIS diabetic rats after RYGB.RYGB or sham was conducted spontaneous...
Abstract Background Oxidative stress has been implicated in the pathogenesis of chronic kidney disease (CKD), prompting exploration antioxidants as a potential therapeutic avenue for mitigating progression. This study aims to investigate beneficial impact Tempol on progression CKD rat model utilizing oxidized albumin biomarker. Methods After four weeks treatment, metabolic parameters, including body weight, left ventricle residual urine volume, and water food intake, were measured. Systolic...
An efficient HMFCA production strategy was developed using a new whole-cell biocatalyst from <italic>Pseudomonas aeruginosa</italic> PC-1.
Upgrading of biomass derived 5-hydroxymethylfurfural (HMF) has attracted considerable interest recently. A new highly HMF-tolerant strain Burkholderia contaminans NJPI-15 was isolated in this study, and the biocatalytic reduction HMF into 2,5-bis(hydroxymethyl)furan (BHMF) using whole cells reported. Co-substrate applied to improve BHMF yield selectivity as well level. The catalytic capacity can be substantially improved by Mn 2+ ion. exhibited good performance at a pH range 6.0–9.0...
Summary The natural flavonoids luteolin and luteoloside have anti‐bacterial, anti‐inflammatory, anti‐oxidant, anti‐tumour, hypolipidemic, cholesterol lowering neuroprotective effects, but their poor water solubility limits application in industrial production the pharmaceutical industry. In this study, luteolin‐7‐ O ‐β‐(6″‐ ‐succinyl)‐ d ‐glucoside, a new compound that was prepared by succinyl glycosylation of organic solvent tolerant bacterium Bacillus amyloliquefaciens FJ18 an 8.0% DMSO...
Abstract In this study, we investigated how Roux‐en‐Y gastric bypass (RYGB) enhances glucagon‐like peptide 1 (GLP‐1) response in GK rats and explored the potential link between RYGB‐stimulated BAs/FXR signalling GLP‐1R‐linked β‐cells, a key pathway that regulates glucose‐stimulated insulin secretion (GSIS). Here show RYGB restores GLP‐1R expression rat islets. This involves increased total BAs as well chenodeoxycholic acid (CDCA), leading to FXR activation, increasing binding promoter of...
Adenylyl cyclase 8 (ADCY8) and Farnesoid X Receptor (FXR) have been identified in pancreatic β-cells play important roles insulin secretion. But the mechanisms underlying with respect to regulation of ADCY8 expression β-cells, particularly whether FXR is involved, remain unexplored. We now show that decreased Goto-Kakizaki (GK) rat islets compared healthy Wistar controls. also found reduced associated FXR. Consistently, was suppressed by knockdown INS-1 832/13 cells, as well from knockout...
A new whole-cell biocatalyst E. ludwigii YYP3 was applied in the conversion of HMF to BHMF and exhibited outstanding catalytic efficiency cycling stability. Its underlying molecular mechanism, especially target enzymes responsible for reduction, revealed.
Abstract Raspberry ketone is a primary aroma component of the red raspberry. The glycosylation this compound potential approach used to improve its pharmaceutical properties. In work, raspberry glycosides are produced in bacteria for first time. Bacillus licheniformis PI15, an organic solvent‐tolerant glycosyltransferase‐producing strain, was isolated from chemically polluted soil. cloning and heterologous expression glycosyltransferase, which designated PI‐GT1, Escherichia coli BL21...
<p dir="ltr">Roux-en-Y gastric bypass (RYGB) has been shown to inhibit β-cell apoptosis, but the underlying mechanisms are not yet fully understood. Cytochrome c oxidase subunit 6A2 (COX6A2) is expressed in β-cells. Here, we sought investigate role of COX6A2 especially following RYGB. We found that RYGB significantly reduced accompanied by decreased expression islets from diabetic Goto-Kakizaki (GK) rats. It noteworthy overexpression promoted whereas deficiency suppressed it,...
<p dir="ltr">Roux-en-Y gastric bypass (RYGB) has been shown to inhibit β-cell apoptosis, but the underlying mechanisms are not yet fully understood. Cytochrome c oxidase subunit 6A2 (COX6A2) is expressed in β-cells. Here, we sought investigate role of COX6A2 especially following RYGB. We found that RYGB significantly reduced accompanied by decreased expression islets from diabetic Goto-Kakizaki (GK) rats. It noteworthy overexpression promoted whereas deficiency suppressed it,...
Roux-en-Y gastric bypass (RYGB) has been shown to inhibit β-cell apoptosis, but the underlying mechanisms are not yet fully understood. Cytochrome c oxidase subunit 6A2 (COX6A2) is expressed in β-cells. Here, we sought investigate role of COX6A2 especially following RYGB. We found that RYGB significantly reduced accompanied by decreased expression islets from diabetic Goto-Kakizaki (GK) rats. It noteworthy overexpression promoted whereas deficiency suppressed it, suggesting pro-apoptotic...