A5023054392- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Medical Imaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Bioactive Compounds
- Functional Brain Connectivity Studies
- Emergency and Acute Care Studies
- Ferroptosis and cancer prognosis
- Molecular spectroscopy and chirality
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Analytical Chemistry and Chromatography
- Medical Imaging and Analysis
- Bioinformatics and Genomic Networks
- Flavonoids in Medical Research
- Cytokine Signaling Pathways and Interactions
- Traditional Chinese Medicine Analysis
- Sarcoma Diagnosis and Treatment
- Crystallization and Solubility Studies
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Pharmacological Receptor Mechanisms and Effects
- Advanced Neuroimaging Techniques and Applications
- Cannabis and Cannabinoid Research
Shanghai University of Traditional Chinese Medicine
2019-2025
Yale University
2012-2025
Henan University
2021-2024
Henan Provincial People's Hospital
2021-2024
Zhengzhou University
2007-2024
And Technology Research (United Kingdom)
2024
Weatherford College
2022-2024
Guangxi Medical University
2013-2023
PLA Information Engineering University
2022
University of Science and Technology of China
2016
Chirality is one of the essential attributes nature. Chiral drugs refer to a class containing chiral centers, and molecular stereo-structures their enantiomers are non-superimposable mirror images each other. Sixty percent commonly used drugs, including those from traditional Chinese medicine (TCM), chiral. Developing single enantiomer with high efficiency low toxicity has drawn considerable attention due significant differences in pharmacological activities, metabolic processes, exhibited...
Objectives: To test the feasibility of using a home-based sleep restriction protocol in adolescents and young adults; to examine different effects chronic on subjective sleepiness scale working memory task adults. Method: Twenty (ages 13–16 years) 20 adults 18–20 underwent 2-week manipulation consisting week 5 school days with 8 hr spent bed per night another 6 night. The used counterbalanced crossover experimental design. Subjective was scored by participant each morning, tests were...
Ischemic stroke is a common intravascular disease and one of the leading causes death disability. The salidroside derivative SHPL-49, which we previously synthesized, significantly attenuates cerebral ischemic injury in rat model permanent middle artery occlusion. To explore neuroprotective mechanism effects SHPL-49 on expression levels neurotrophic factors neurons microglia polarization were investigated present study. activated brain-derived factor (BDNF) pathway, decreased number...
Asthma, the prototypic Th2-mediated inflammatory disorder of lung, is an emergent disease worldwide. Vascular endothelial growth factor (VEGF) a critical regulator pulmonary Th2 inflammation, but underlying mechanism and roles microRNAs (miRNAs) in this process have not been defined. Here we show that lung-specific overexpression VEGF decreases miR-1 expression most prominently endothelium, similar down-regulation occurs lung endothelium inflammation models. Intranasal delivery inhibited...
Cannabis has been used for centuries to treat pain. The antinociceptive activity of tetrahydrocannabinol (THC) or cannabidiol (CBD) widely studied. However, the effects other cannabis components, such as cannabichromene (CBC) and cannabigerol (CBG), have rarely revealed. mechanism CBG is not yet clear, so we investigated effect on different pain models, explored action exert effects. In current study, compared CBC, CBD, carrageenan-induced inflammatory model in mice, results showed that had...
The neuroinflammation triggered by cellular demise plays a pivotal role in ameliorating the injury associated with ischemic stroke, which represents significant global burden of mortality and disability. compound SHPL-49, derivative rhodioloside, was discovered our research team has previously demonstrated neuroprotective effects rats stroke. This study aimed to elucidate underlying mechanisms SHPL-49’s protective effects. Preliminary investigations revealed that SHPL-49 effectively...
Cigarette smoke (CS) creates a "cancer field" in the lung that promotes malignant transformation. The molecular changes within this field are not fully characterized. We examined significance of microRNA-1 (miR-1) downregulation as one these changes. found tumor miR-1 levels three non-small cell cancer cohorts show inverse correlations with smoking burden. Lung MiR-1 follow spatial gradient, have prognostic significance, and correlate inversely markers injury. In CS-exposed lungs, is...
HuR is a member of the Drosophila Elav protein family that binds mRNA degradation sequences and prevents RNase-mediated degradation. Such HuR-mediated stabilization, which stimulated by integrin engagement controlled at level nuclear export, critically involved in T-cell cytokine production. However, HuR's role macrophage soluble factor production, particular response to angiogenic stimuli, has not yet been established. We show labile transcripts encode vascular endothelial growth matrix...
Ischemic stroke is a significant cause of death and disability with limited treatment time window. The reduction early glutamate excitotoxicity using neuroprotective agents targeting N-methyl-d-aspartic acid (NMDA) receptors have attracted recent research attention. SHPL-49, structurally modified derivative salidroside, was synthesized by our team. Previous studies confirmed the efficacy SHPL-49 in rats ischemic stroke. However, underlying mechanisms need to be clarified.
Bufotalin (BT), a major active constituent of Chansu, has been found to possess multiple pharmacological activities. Although previous studies have shown that BT could inhibit the growth glioblastoma (GBM), safety in vivo and potential mechanism are still unclear. We conducted systematic assessment investigate impact on GBM cell viability, migration, invasion, colony formation. Furthermore, results were obtained evaluate effect tumor growth. The preliminary findings our study demonstrate...
Abstract Background Metabolic syndrome is often beneficial from testosterone replacement therapy. Although and sex hormone‐binding globulin (SHBG) are inversely associated with the risk of metabolic syndrome, it controversial whether association between independent SHBG. Methods Testosterone, SHBG were evaluated in 2361 men aged 20–73 years, who participated population‐based Fangchenggang Area Male Health Examination Survey. Total testosterone, other biochemical profiles measured. Free...
There is evidence that the Crystallin Alpha B (CRYAB) gene involved in regulation of tumor microenvironment and influences prognosis some cancers. However, role CRYAB immunology pan-cancer still unclear.In this study, we analyzed transcriptional profiles survival data cancer patients from The Cancer Genome Atlas (TCGA) database. its relationships with were using R packages, TIMER2.0, GEPIA2, Sangerbox, UALCAN, cBioPortal, ESTIMATE algorithm, STRING. Besides, real-time fluorescence...
Background The aim of this study was to investigate the current state disaster preparedness and determine associated factors among emergency nurses from tertiary hospitals in Henan Province China. Methods This multicenter descriptive cross-sectional conducted with 48 China between September 7, 2022–September 27, 2022. Data were collected through a self-designeds online questionnaire using mainland version Disaster Preparedness Evaluation Tool (DPET-MC). Descriptive analysis multiple linear...
Renal cell carcinoma (RCC) is the most lethal type of cancer in urinary system and often presents as a metastatic disease. Furthermore, there are no effective treatments for Several studies based on gene expression profiling have been performed with aim gaining insights into pathogenesis RCC; however, few investigated RCC at pathway level to search possible pathways involved clear (CCRCC). In this study, set enrichment analysis (GSEA) was conducted microarray datasets from CCRCC tissue....
Background Prehospital emergency care is a critical but often understudied aspect of healthcare. Patient vulnerability in this setting can significantly impact outcomes. The aim study was to investigate the status and determine associated affect factors among prehospital patients China. Methods In cross-sectional conducted China, from April 2023 July 2023, we assessed using Safety Emergency Care Index (SPECI) scale. We detailed questionnaire-based survey gather demographic disease-related...
Mean diffusivity (MD) derived from diffusion tensor imaging has shown its ability to assess the microscopic structural integrity damage of gray matter in amnestic mild cognitive impairment (aMCI), a prodromal stage Alzheimer's disease (AD). Howeve