A5008846255- Per- and polyfluoroalkyl substances research
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Atmospheric Ozone and Climate
- Toxic Organic Pollutants Impact
- Gestational Diabetes Research and Management
- Health, Environment, Cognitive Aging
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Fluoride Effects and Removal
- SARS-CoV-2 detection and testing
- Folate and B Vitamins Research
- Anesthesia and Neurotoxicity Research
- Bone health and osteoporosis research
- Maternal Mental Health During Pregnancy and Postpartum
- Cystic Fibrosis Research Advances
- Long-Term Effects of COVID-19
- Neonatal Health and Biochemistry
- Quantum Electrodynamics and Casimir Effect
- Racial and Ethnic Identity Research
- Metabolomics and Mass Spectrometry Studies
- Delphi Technique in Research
- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
Emory University
2020-2025
Florida State University
2024
Abstract Marginalized populations experience disproportionate rates of preterm birth and early term birth. Exposure to per- polyfluoroalkyl substances (PFAS) has been reported reduce length gestation, but the underlying mechanisms are unknown. In present study, we characterized molecular signatures prenatal PFAS exposure gestational age at outcomes in newborn dried blood spot metabolome among 267 African American dyads Atlanta, Georgia between 2016 2020. Pregnant people with higher serum...
Oxidative stress from excess reactive oxygen species (ROS) is a hypothesized contributor to preterm birth. Per- and polyfluoroalkyl substances (PFAS) exposure reported generate ROS in laboratory settings, linked adverse birth outcomes globally. However, our knowledge, the relationship between PFAS oxidative has not been examined context of human pregnancy.To investigate associations prenatal biomarkers among pregnant people.Our analytic sample included 428 participants enrolled Illinois Kids...
Prenatal exposure to single chemicals belonging the per- and polyfluoroalkyl substances (PFAS) family is associated with biological perturbations in mother, fetus, placenta, plus adverse health outcomes. Despite our knowledge that humans are exposed multiple PFAS, potential joint effects of PFAS on metabolome remain largely unknown. Here, we leveraged high-resolution metabolomics identify metabolites metabolic pathways perturbed by a mixture during pregnancy. Targeted assessment...
Per- and polyfluoroalkyl substances (PFAS) have been identified as environmental contributors to adverse birth outcomes. One potential mechanistic pathway could be through PFAS-related inflammation cytokine production. Here, we examined associations between a PFAS mixture inflammatory biomarkers during early late pregnancy from participants enrolled in the Atlanta African American Maternal–Child Cohort (N = 425). Serum concentrations of multiple were detected >90% samples at 8–14 weeks...
We evaluated associations among exposure to prenatal phthalate metabolites, perturbations of the newborn metabolome, and infant neurobehavioral functioning in mother-newborn pairs enrolled Atlanta African American Maternal-Child Cohort during 2016-2018. quantified eight metabolites urine samples collected between 8- 14-weeks' (visit 1; n = 216) 24- 30-weeks' gestation 2; 145) metabolite features dried-blood spot at delivery. Associations concentrations metabolic feature intensities both...
Bone is a dynamic tissue that in constant state of remodeling. turnover markers (BTMs), procollagen type I N-terminal propeptide (P1NP) and C-terminal telopeptides collagen (CTX), provide sensitive measures bone formation resorption, respectively. This study used ultra-high-resolution metabolomics (HRM) to determine plasma metabolic pathways targeted metabolites related the resorption adults. cross-sectional clinical included 34 adults (19 females, mean 27.8 years), without reported...
Longitudinal trends in per- and polyfluoroalkyl substances (PFAS) serum concentrations across pregnancy have not been thoroughly examined, despite evidence linking prenatal PFAS exposures with adverse birth outcomes.
Background: Antibodies against SARS-CoV-2 can be detected by various testing platforms, but a detailed understanding of assay performance is critical. Methods: We developed and validated simple enzyme-linked immunosorbent (ELISA) to detect IgG binding the receptor-binding domain (RBD) SARS-CoV-2, which was then applied for surveillance. ELISA results were compared set complimentary serologic assays using large panel clinical research samples. Results: The RBD exhibited robust in ROC curve...